Loren Data's SAM Daily™

FBO DAILY ISSUE OF SEPTEMBER 18, 2002 FBO #0290
SOLICITATION NOTICE

A -- Innate Immune Receptors and Adjuvant Discovery

Notice Date

9/16/2002
 

Notice Type

Solicitation Notice
 

Contracting Office

Department of Health and Human Services, National Institutes of Health, National Institutes of Allergy and Infectious Diseases, Contract Management Branch 6700 B Rockledge Room 2230 MSC7612, Bethesda, MD, 20892-7605
 

ZIP Code

20892-7605
 

Solicitation Number

RFP-NIH-NIAID-DAIT-BAA-03-41
 

Point of Contact

Paul McFarlane, Senior Contracting Officer, Phone 301-496-0349, Fax 301-402-0972, - Paul McFarlane, Senior Contracting Officer, Phone 301-496-0349, Fax 301-402-0972,
 

E-Mail Address

pm24v@nih.gov, pm24v@nih.gov
 

Description

The Division of Allergy, Immunology, and Transplantation (DAIT), at the National Institute of Allergy and Infectious Diseases (NIAID) promotes and supports a broad range of research projects on basic mechanisms of immune function, including studies of innate immunity and the immunological basis of vaccines and adjuvants. The purpose of this Broad Agency Announcement (BAA) ?Innate Immune Receptors and Adjuvant Discovery? is to solicit proposals for a research program beginning at the discovery/molecular response evaluation stage and progressing to preclinical testing of new adjuvants based upon triggering of the human innate immune system. For the purpose of this BAA, adjuvants are defined as molecules that act via innate immune system signaling to activate desired innate and adaptive (T-cell and antibody-mediated) immune responses. The adjuvant products aimed for in this program may encompass uses both as vaccine adjuvants, to elicit T- and B cell responses when co-administered with an immunogen, as well as stand-alone immunomodulators to stimulate short term protective responses against broad categories of infectious agents. Research must be directed toward vaccine adjuvants and immune stimulation strategies to defend against NIAID categories A, B, or C agents. These pathogens are listed at the website: http://www.niaid.nih.gov/dmid/bioterrorism/bandc_priority.htm. The following research areas will be part of this requirement: (1.a.) High throughput analytical approaches to identify and characterize innate immune receptors and/or their ligands. This includes use of existing techniques or the development of improved methods including genomic and proteomic approaches to identify receptors and/or their ligands, as well as structure-activity relationship studies (SAR) of innate immune receptor-ligand interactions. Ligands may include both direct and indirect triggers of the receptors. (1.b.) Analyses and evaluation of cellular responses activated by innate receptors/ligands. The overall goal of this research area is to understand the direct and indirect effects of receptor-mediated activation in order to focus on desired responses for lead development. (2) Lead compound identification and improvement based upon mechanism of action; and, (3) Preclinical testing of compounds with adjuvant activity emerging from the above research. The ultimate goal of this effort is to protect the human population from infectious diseases; therefore, research must result in adjuvants that are effective in the human innate immune system. This RFP is discovery focused and does not solicit proposals to study already known adjuvants or adjuvants currently in development. Detailed information on the technical requirements follows in the ?Technical Objectives? section. Projects concerning adjuvants for biodefense that are not within the scope of this solicitation may be eligible for support by other NIAID solicitations as indicated on the web page at http://www.niaid.nih.gov/dmid/bioterrorism/fund_opp_table.htm. Inquiries may be directed to Program Staff indicated on the web site. It is anticipated that up to five (5) cost reimbursement, completion type contracts will be awarded for a period of five (5) years each, beginning approximately September 30, 2003. RFP NIH-NIAID-DAIT-BAA-03-41 will be available electronically on or about September 27, 2002, and may be accessed through the NIAID Contract Management Branch (CMB) Home page at http://www.niaid.nih.gov/cgi-shl/cmb/rfps.cfm. Please note that the RFP for this acquisition only includes the work statement, deliverable and reporting requirements, special requirements, the technical evaluation criteria, and the proposal preparation instructions. All information required for the submission of an offer will be contained in the electronic RFP package. Following proposal submission and the initial review process, Offerors comprising the competitive range will be asked to provide additional documentation to the Contracting Officer. Responses to this RFP will be due approximately January 7, 2003. Any responsible Offeror may submit a proposal, which will be considered by the Government. This advertisement does not commit the Government to award a contract. Point of contact: Wanda Neal, Contract Specialist at wneal@niaid.nih.gov, telephone: (301) 496-0189, FAX: (301) 480-5253 you may also contact Paul McFarlane, Contracting Officer, Phone (301) 496-0349, email pm24@nih.gov. No collect calls will be accepted.
 

Place of Performance

Address: To Be Determined

Zip Code: TBD

Country: TBD
 

Record

SN00167615-W 20020918/020916213248 (fbodaily.com)
 

Source

FedBizOpps.gov Link to This Notice
(may not be valid after Archive Date)

---

| FSG Index  |  This Issue's Index  |  Today's FBO Daily Index Page |