SOURCES SOUGHT
A -- Large-Scale Sequencing of Microbial Genomes
- Notice Date
- 11/1/2002
- Notice Type
- Sources Sought
- Contracting Office
- Department of Health and Human Services, National Institutes of Health, National Institutes of Allergy and Infectious Diseases, Contract Management Branch 6700 B Rockledge Room 2230 MSC7612, Bethesda, MD, 20892-7605
- ZIP Code
- 20892-7605
- Solicitation Number
- Reference-Number-SSB0311
- Archive Date
- 11/30/2002
- Point of Contact
- Carl Newman, Contract Specialist, Phone 301-496-8371, Fax 301-480-5253, - Paul McFarlane, Senior Contracting Officer, Phone 301-496-0349, Fax 301-402-0972,
- E-Mail Address
-
CNewman@niaid.nih.gov, pm24v@nih.gov
- Description
- The National Institute of Allergy and Infectious Diseases (NIAID) is seeking Capability Statements from organizations with the ability to provide the following effort. 1.Provide state-of-the-art, large scale sequencing facilities including DNA sequencers and all necessary equipment, methods, infrastructure and technologies required for producing, high quality DNA sequencing of microbial genomes and invertebrate vectors of diseases at a competitive cost. This work shall include: constructing high quality, random plasmid and other genomic libraries; preparing high quality templates; producing high quality, finished DNA sequence from a variety of different vectors; performing multiple sequencing approaches such as sequencing of ESTs, BAC-ends and whole genome shotgun; assembling and closing microbial genomes; and performing automated and manual annotation with gene finding and identification. 2.Provide a facility with an annual sequencing capacity at a minimum of 6,000,000 sequences/year with capacity to increase. 3.Produce and conduct DNA sequence completed to the contemporary standard for high quality genomic DNA sequence. Currently, this is a base pair accuracy of 99.99% (no more than one (1) error per 10,000 bases). Provide the ability to assign a quality value to sequencing data produced. 4.Provide leadership and research and administrative expertise that include all expertise to produce high-quality microbial genome DNA sequence of microorganisms and invertebrate vectors of diseases. 5.Provide scientific and administrative expertise and leadership to design strategies for sequencing genomes of both microbes and invertebrate vectors of diseases. 6.Provide all facilities and expertise to support and develop bioinformatics and computational tools required for a state-of-the-art DNA sequencing facility. These tools include, but are not limited to the following: infrastructure tracking of samples and data; assessment of quality sequence data; analysis of microbial genome sequence data; storing, visualizing and releasing genome data and annotation for web; transferring genome data to international sequencing databases; and assembling and closing microbial genomes and invertebrate vectors of disease from shotgun reads and other sequence data. 7.Provide capabilities for releasing DNA sequence and accompanying annotation data in a timely, publicly accessible manner, including a publicly accessible web site and a peer-reviewed publication. 8.Coordinate and collaborate with other U.S. and international sequencing centers and associated research communities involved in sequencing microbial genomes and invertebrate vectors of disease. 9.Maintain a cost for DNA sequencing that is competitive with state-of-the-art large-scale international sequencing centers. This announcement is not a request for proposal. There is no RFP available and the government is not committed to award a contract pursuant to this announcement. All responses shall be received no later than Friday, November 15, 2002. Please address all responses to the attention of Carl Newman, Contract Specialist, National Institute of Allergy and Infectious Diseases, NIH, DHHS, Contract Management Branch, 6700B Rockledge Drive, Room 2230, MSC 7612, Bethesda, MD. 20892-7612.
- Record
- SN00197789-W 20021103/021102095035 (fbodaily.com)
- Source
-
FedBizOpps.gov Link to This Notice
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