SOLICITATION NOTICE
A -- Armored Enzyme Nanoparticles
- Notice Date
- 2/7/2003
- Notice Type
- Solicitation Notice
- Contracting Office
- Department of Energy, Pacific Northwest National Laboratory - Battelle (DOE Contractor), PNNL Licensing, PO Box 999, MSIN K9-62, Richland, WA, 99352
- ZIP Code
- 99352
- Solicitation Number
- Reference-Number-13650-E
- Archive Date
- 5/20/2003
- Point of Contact
- Connie Mitzel-Faulk, Licensing Staff, Phone (509) 375-6401, Fax (509) 375-6731,
- E-Mail Address
-
technology@pnl.gov
- Description
- Pacific Northwest National Laboratory (PNNL), operated by Battelle Memorial Institute under contract to the U.S. Department of Energy, solicits interest from companies interested in obtaining license rights to commercialize, manufacture and market the following technology. License rights may be issued on an exclusive or nonexclusive basis and may include specific fields of use. PNNL may also be available to licensee(s) to assist in further research and development of the technology under a sponsored research agreement or CRADA program. The Technology: Enzymes are useful for bio-processing at a nanoscale. However, a serious drawback to their use is that when exposed in a solution, they have very short lifetimes. Present ways of ameliorating this problem involve immobilizing the protein on a solid support or entrapping them in a support matrix. To a degree, these methods are successful; however, for many reasons, they do not completely solve the problem and in fact, may cause the enzyme to become inactivated during the immobilization process. In addressing this problem, researchers at DOE?s Pacific Northwest National Laboratory have developed armored, single-enzyme nanoparticles which dramatically stabilize a protein by surrounding each enzyme with a porous composite organic/inorganic shell of less than a few nanometers thick. While such armored enzymes show some decrease in efficiency, they are stable for long periods of time and have the same binding constant as free enzyme. Experimental data suggest the armored shell is porous enough not to interfere with the proteolysis of proteins up to a molecular weight of 66K. These armored single-enzyme nanoparticles remain soluble in aqueous solutions and can be immobilized onto solid supports or matrices for applications that require that form. Any company interested in licensing this technology must respond with a letter of interest (may be submitted by e-mail) no later than 90 days from the publication date of this Notice summarizing the company?s business and technical expertise and motivation for pursuing this opportunity. Companies deemed appropriate will be provided with further information on the technology. Such information may require an executed Nondisclosure Agreement. Respondents wishing to enter into negotiations for a commercial license will be required to submit a business plan for the commercialization of the technology prior to licensee(s) selection and negotiations. Please send letters of interest to the attention of the POC identified within this Notice.
- Record
- SN00255342-W 20030209/030207213313 (fbodaily.com)
- Source
-
FedBizOpps.gov Link to This Notice
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