SOLICITATION NOTICE
66 -- Avance 500 Console and 500 MHz Cryoprobe Accessory along w/Optional Accessory
- Notice Date
- 8/21/2003
- Notice Type
- Solicitation Notice
- Contracting Office
- Department of Health and Human Services, National Institutes of Health, Nat'l Institute of Diabetes, Digestive, & Kidney Diseases, 2 Democracy Plaza, Suite 700W 6707 Democracy Blvd., MSC 5455, Bethesda, MD, 20892-5455
- ZIP Code
- 20892-5455
- Solicitation Number
- NIH-NIDDK-03-991
- Response Due
- 9/5/2003
- Archive Date
- 9/20/2003
- Point of Contact
- Patricia Haun, Purchasing Agent, Phone (301) 594-8855, Fax (301) 480-4226,
- E-Mail Address
-
haunp@extra.niddk.nih.gov
- Description
- This is a combined synopsis/solicitation for commercial items prepared in accordance with the format in FAR 12.6 as supplemented with additional information included in this notice. This announcement constitutes the only solicitation and a separate written solicitation will not be issued. This solicitation number is NIH-NIDDK-03-991, and is issued as a Request for Quotation (RFQ). The solicitation/contract will include all applicable provisions and clauses in effect through Federal Acquisition Circular 2001-14. The North American Industry Classification (NAICS) Code is 339111 and the business size standard is 500 Employees. However, this solicitation is not set aside for small business. This acquisition is being conducted using Simplified Acquisition Procedures in accordance with FAR Part 13. It is the intent of the National Institutes of Health (NIH), National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) to purchase an Avance? 500 Console and 500MHz Cryoprobe? Accessory along with the Optional Accessory (set of magnet vibration isolation posts, for severe reduction of the effects of strong floor vibrations) from Bruker Biospin 15 Fortune Drive, Manning Park, Billerica, MA 01821. The Mandatory Technical Specifications are as follows: All specifications must be guaranteed on site and must have been achieved by the offeror at the time the proposal is being submitted. A NMR spectrometer console upgrade is requested for an existing 500 MHz Oxford superconducting magnet. 1) The console shall be fully compatible with all other solution-state NMR spectrometers presently in use in the Laboratory of Chemical Physics, NIDDK. These include one DRX-800 spectrometer, one DMX-750 spectrometer, two DMX-600 spectrometers, two DRX-600 spectrometers and two DMX-500 spectrometers. The new instrument shall have the same operating and pulse programming software as the existing instruments, or the offeror shall replace all existing consoles and probes to make them identical in architecture and software to the 500 MHz spectrometer. If consoles on existing spectrometers are to be replaced, it is the offeror?s responsibility that the instruments meet all technical specifications and capabilities currently met by these spectrometers. 2) The magnet control system shall be equipped with a room temperature shim systems comprising 28 shim gradients. The shim and digital lock control unit shall include digital lock frequency generation, digital quadrature lock receiver, fast-field adjustments with sample-and-hold, a microprocessor-controlled lock regulation system, and shim control boards with ultra-stable, high precision, low noise shim current sources. The system shall be equipped with a shim keyboard control unit for full manual and computer automated control of the lock, sample spinning and room temperature shims. 3) The spectrometer shall provide a minimum of five frequency channels together with the capability of producing different asynchronous or synchronous composite pulse decoupling and different shaped pulses on all of these channels simultaneously and independently. The composite pulse decoupling schemes must be freely programmable by the user and include the option for pulse shaping of the individual elements of the composite pulses. All channels shall have identical specifications at low rf power levels, except that only one channel requires operation over the frequency range from 458 to 501 MHz (for 19F and 1H), and a minimum of three channels shall operate over the frequency range from 25 to 205 MHz (all other nuclei). 4) The system shall include two 3-axis triple resonance (13C/15N/1H) triple gradient (x,y,z) 5-mm pulsed field gradient probehead for observation of 1H while decoupling 13C and 1N, include 2H lock, and the 900 pulse widths must be <8 microseconds for 13C and <45 microseconds for 15N, and <70 ms for 2H, for an aqueous non-saline sample. In addition, the 1H RF homogeneity of the triple resonance probehead must be such that a 8100 1H pulse (2 x 3600 + 900) retains at least 70% of the signal relative to a single 900 pulse, using an aqueous solution containing 2 mM sucrose in D20. The 13C RF homogeneity must be such that after a 900 (1H)- 1/2JCH ? 7200 (13C) pulse sequence the methyl signal for a sample of 13C-enriched acetate is attenuated by less than 30% relative to the 1H signal acquired with a 900 (1H) ? 1/2J ?00 (13C) pulse sequence. 5) The 1H sensitivity specifications for the triple resonance pulsed field x,y,z, gradient 5 mm probeheads, using Wilmad-535 sample tubes shall be: (i) ASTM 0.1% ethylbenzene > 900:1; (ii) 0.5 mg sucrose/ml D20 > 90:1; (iii) 0.5 mg sucrose/ml in 200 nM NaCl in D20 > 65:1 Specifications (ii) and (iii) shall be carried out using a single scan, the free induction decay shall processed with an exponential line broadening of 1 Hz, and the noise assessed over a 1 ppm width 6) The system shall be equipped with hardware and software for mapping the magnetic field profile within the sample in three orthogonal dimensions, and software for making the required homogeneity adjustments under computer control. The spectrometer shall be capable of doing this for samples dissolved in D2O and in H2O. The spectrometer shall also include the capability to automatically adjust the homogeneity of the magnetic field during the course of multi-hour experiments, which include pulsed field gradients, without interrupting the actual experiments or having any other noticeable effect on the acquisition process. 7) The system shall include a triple resonance inverse detection cryoprobe for 1H observe with 15N and 13C decoupling, a 2H lock channel and a z-gradient coil for the application of pulse field gradients. The cryoprobe shall meet the following specifications: (i) The 1H S/N ratio shall be ≥3000:1 for 0.1% ethylbenzene (over 200 Hz noise). (ii) The 1H S/N ratio on the anomeric proton of a 0.5 mg sucrose/ml D2O sample shall be ≥300:1 (recorded with 1 scan, and processed with exponential line broadening of 1 Hz with the noise measured over 1 ppm). (iii) The 1H pulse width shall be ≤8 microseconds. (iv) The 13C pulse width shall be ≤13 microseconds (v) The 15N pulse width shall be ≤50 microseconds. (vi) The 1H non-spinning lineshape on a 1% chloroform sample shall be ≤12/24 Hz (0.55%/0.11%) (vii) The recovery of the magnetic field homogeneity shall be such that a signal acquired 200 ms after a 1 ms gradient applied simultaneously in the z direction at 50% of maximum power, differs by less than 3% from that acquired without the preceding gradient pulse. This shall be measured for a sample of 2 mM sucrose in D2O solution, using 1 Hz exponential line broadening and identical phasing. 8) The pulse programming system shall permit implementation of user-developed pulse sequences and shall be capable of conducting all experiments published in the volumes 1-26 of the Journal of Biomolecular NMR. It shall be possible to specify at least 30 independent pulse sequence interval lengths and 30 pulse widths in a single pulse program. The minimum interval length shall be no greater than 500 ns. It shall be possible to specify each interval length in increments of 25 ns or less. It shall be possible to write and execute pulse programs with at least 256 steps (without loops), with each step representing a time period during which any combination of pulses on the five channels is given. The amplitudes and phases of the pulses shall be arbitrarily programmable, subject only to the resolution limits on the phase shifters and rf attenuators. It shall be possible to include at least twenty loops within a single pulse program, with independent loop counters. It shall be possible to nest loops. 9) The console electronics shall be capable of 0.5 degree phase resolution, 0.1 Hz frequency resolution and a 90 dB attenuation range on all five channels. The RF phase shall vary by no more than 3˚ over an attenuation range of 45 dB from full power. 10) At any offset, the excitation profile of a 1H shaped pulse shall be within 50% from its theoretical profile, as tested for the residual HDO line in a D2O sample, for offsets of up to 10 ppm. At any offset, the excitation profile of a 15N or 13C shaped pulse shall be within 50% from its theoretical limit for offsets up to 100 ppm. 11) The console shall be able to pulse and observe 2H nuclei without physically recabling the console, and capable of applying 90˚ 2H pulse widths of less than 65 microseconds. 12) The long term pulse amplitude stability on all channels shall be ≤ 1% and phase stability shall be better than 1˚, as measured over a 24 h period in a room where the temperature changes by less than 1.5 ˚C. This phase stability is measured from the relative difference between 1D spectra, recorded with a 30˚ flip angle pulse, at various times during a 24 h period. 13) The system shall be capable of performing spin lock experiments on the 5-mm triple resonance 3-axis gradient probeheads for up to 100 ms for 1H (B1 = 12 kHz), up to 50 ms for the 13C channels (B2 = 12 kHz for 13C), and up to 120 ms for the 15N channel (B2 = 3 kHz for 15N), with droop ≤ 2%, and total duty cycles (time with RF on divided by total time) of up to 5%, for a one-hour period. 14) The console electronics shall permit application of user defined shaped pulses to operate independently on each of the available channels. The shaped pulses must allow a minimum of 16000 user-definable elements within a single pulse shape. The dynamic range of each channel for shaped pulses must be at least 70 dB total range with 0.1 dB resolution half range. 15) The system shall be capable of independent and simultaneous control over amplitude, frequency, phase and duration of pulses for all frequency channels and over internal real-time clock pulses for triggering of external devices. 16) The console shall be equipped with a digitizer of at least 16 bits allowing simultaneous sampling of the quadrature receiver channels for spectral widths of up to at least 125 kHz. The system shall also be capable of oversampling and digital filtering of the NMR audio signal. In addition, no DC offset correction in the time domain shall be required on data acquired with a single scan, independent of receiver gain setting. 17) The system shall be equipped with a pulse program controlled pulsed field gradient power supply, capable of generating a field gradient along the z axis with a strength of at least 50 G/cm and at least 25 G/cm in the x and y directions, for the 5 mm probehead. The recovery of the magnetic field homogeneity shall be such that a signal acquired 200 s after a 1 ms gradient applied simultaneously in the x, y, and z directions at 50% of maximum power, differs by less than 3% from that acquired without the preceding gradient pulse. This shall be measured for a sample of 2 mM sucrose in D2O solution, using 1 Hz exponential line broadening and identical phasing. 18) Before high-power amplification, pulse rise and fall times shall be <300 ns, measured between 10% and 90% amplitude levels. Fast power switching (≤3 s) must be provided on all five channels. 19) The system shall have the capability of viewing the lock 2H signal in the frequency-swept mode with full control over the irradiated power, the sweep rate, and the sweep amplitude, without recabling or otherwise modifying the hardware setup from the spectrometer's normal mode of operation. 20) The system shall have the capability to conduct variable temperature experiments over the range of 0 to 60 ˚C in normal operation, without the requirement of external cooling substances such as liquid nitrogen or dry ice. The system shall be capable of operating in the variable temperature mode using nitrogen gas and meet all the above listed performance specifications. The sample temperature shall be adjustable in 0.1 ˚C increments. 21) The dynamic range shall be at least 60,000:1 as measured for a 90? 1H pulse by a S/N of at least 60:1 on a t-butanol peak in a 1/10,000 1H molar ratio to water. No spurious resonances shall be larger than 1/2000 times the largest resonance in the spectrum when operating in locked mode, using sample temperature control at 30 ˚C, and an air flow which is sufficient to change the sample temperature from 30 ˚C to 25 ˚C, within 0.1 ˚C, in less than 3 minutes. 22) The system shall be equipped with a variable temperature control unit capable of providing less than 0.02?C sample temperature variation per 1?C room temperature change. The sample temperature control, using the pulsed field gradient triple resonance 5-mm probehead must operate over a range of 0?C to 60?C with setting and control being independent of room temperature. 23) The console shall be equipped with ethernet TCP-IP capability. 24) The console shall be equipped with graphics capability capable of providing a minimum of 160 images per second of a 256 x 256 image matrix, and be capable of providing real-time display of acquired data both during acquisition and during data processing. The graphics display monitor shall be capable of operating in a magnetic field strength of 6 Gauss, or be shielded adequately to display images without loss of resolution relative to the absence of a magnetic field. 25) The system shall start simple one-dimensional pulse programs within 1 second after receiving the keyboard command. The system shall start any other pulse program within 10 seconds after receiving the keyboard command. The system shall have the capability to view the acquired, digitized NMR signal on the screen in real time, while the experiment is in operation. 26) The system shall have the capability of processing and analysing data from a previous experiment while simultaneously acquiring data for a new experiment. This shall hold true for both one- and multi-dimensional experiments, up to three dimensions. 27) The vendor shall take full responsibility for the entire system, including probehead, shim system and superconducting magnet. 28) The system shall be able to conduct the following tests successfully after installation in the buyers laboratory (all tests shall be conducted at 25˚C, while operating in the temperature controlled mode): (A) The largest intensity observed in any of 10 consecutive 1H-13C spin-echo difference spectra for the anomeric proton at 5.4 ppm in a sample containing 50 mg sucrose in 0.5 ml D2O, using the following pulse sequence: 1H 90x - 3 msec - 180x - 3 msec - Acquire 13C 90x 90?x shall be smaller than 1% of the corresponding intensity observed in a single transient spectrum. Parameters: 25?C, SW = 5 kHz, exponential line broadening 1Hz, 13C transmitter at 100 ppm, non-spinning, full power 13C pulses, 4 dummy scans, acquire 2 scans, acquisition time 1.5 sec (8192 complex points, repetition rate 2.5 sec (including the acquisition time). (B) For the same sample, the recovery after a rectangular 1-ms 25 Gauss/cm simultaneous x/y/z pulsed field gradient shall be such that a 1D spectrum (10 kHz spectral width, 1.64 s acquisition time, 1 Hz line broadening) recorded 500 microseconds after the end of the gradient pulse shall differ by less than 3% from a spectrum recorded in the absence of this gradient pulse (using identical phasing and processing parameters). 29) The system shall be covered under full parts and labor hardware and software warranty for a period of one year and a full parts warranty for an additional period of four years starting from the date that all guaranteed specifications resulting from this contract have been met in the buyer's laboratory. Mandatory Technical requirements of the cryoprobe: 1. The S/N ratio shall be ≥3000:1 for 0.1% ethylbenzene (over 200 Hz noise). 2. The S/N ratio on the anomeric proton of a 0.5 mg sucrose/ml D2O sample shall be ≥300:1 (recorded with 1 scan, and processed with exponential line broadening of 1 Hz with the noise measured over 1 ppm). 3. The 1H pulse width shall be ≤8 microseconds. 4. The 13C pulse width shall be ≤13 microseconds 5. The 15N pulse width shall be ≤50 microseconds 6. The 1H non-spinning lineshape on a 1% chloroform sample shall be ≤12/24 Hz (0.55%/0.11%) 7. The recovery of the magnetic field homogeneity shall be such that a signal acquired 200 ms after a 1 ms gradient applied simultaneously in the z direction at 50% of maximum power, differs by less than 3% from that acquired without the preceding gradient pulse. This shall be measured for a sample of 2 mM sucrose in D2O solution, using 1 Hz exponential line broadening and identical phasing. 8. The probe shall be fully compatible with the upgraded 500 MHz spectrometer. 9. The probe shall be provided with a cryo cooling unit system and the cryoprobe shall be compatible with the existing pre-amplifier on this system (which is capable of operation with room temperature and cryoprobes). NIDDK has determined that the only manufacturer that currently makes a cryoprobe compatible with the Upgraded 500 MHz console is Bruker Biospin. This notice of intent is not a request for competitive quotations however, all responses received, within 15 days from the date of publication of this synopsis will be considered by the Government. A determination by the Government not to compete this proposed acquisition is based upon responses to this notice and is solely for the purpose of determining whether to conduct a competitive acquisition. The offeror must include a completed copy of the provision of FAR Clause 52.212-3, Offeror Representations and Certifications ? Commercial Items with its offer. The provisions of FAR Clause 52.212-4, Contract Terms and Conditions ? Commercial Items, applies to this acquisition. The addenda to the clause reads as follows: The offeror must include in their quotation, the unit price, the list price, shipping and handling costs, the delivery period after contract award, the prompt payment discount terms, the F.O.B. Point (Destination or Origin), the Dun & Bradstreet Number (DUNS), the Taxpayer Identification Number (TIN), and the certification of business size. The FAR Clause 52.212-5, Contract Terms and Conditions Required to Implement Statutes or Executive Orders ? Commercial Items ? Deviation for Simplified Acquisitions, applies to this acquisition. The clauses are available in full text at http://www.arnet.gov/far. Interested vendors capable of furnishing the government with the item specified in this synopsis should submit their quotation to the below address. Quotations will be due fifteen (15) calendar days from the publication date of this synopsis or September 5, 2003. The quotation must reference ?Solicitation number? NIH-NIDDK-03-991. All responsible sources may submit a quotation, which if timely received, shall be considered by the agency. Quotations must be submitted in writing to the National Institute of Diabetes and Digestive and Kidney Diseases 6707 Democracy Blvd., Room 774C, Bethesda, Maryland 20817, Attention: Patricia Haun. Faxed copies will not be accepted.
- Place of Performance
- Address: 9000 Rockville Pike, Bethesda, MD
- Zip Code: 20892
- Country: USA
- Zip Code: 20892
- Record
- SN00408630-W 20030823/030821213521 (fbodaily.com)
- Source
-
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