SOLICITATION NOTICE
66 -- DNA Engine Opticon 1 System
- Notice Date
- 8/27/2003
- Notice Type
- Solicitation Notice
- Contracting Office
- Department of Health and Human Services, National Institutes of Health, National Cancer Institute, Research Contracts Br., 6120 Executive Blvd. EPS Suite 600, Rockville, MD, 20852
- ZIP Code
- 20852
- Solicitation Number
- NCI-30122
- Response Due
- 9/12/2003
- Archive Date
- 9/27/2003
- Point of Contact
- Malinda Holdcraft, Purchasing Agent, Phone (301) 402-4509, Fax (301) 402-4513, - Caren Rasmussen, Lead Contract Specialist, Phone (301) 402-4509, Fax (301) 402-4513,
- E-Mail Address
-
holdcram@exchange.nih.gov, cr214i@nih.gov
- Description
- The National Cancer Institute (NCI), Center for Cancer Research (CCR) plans to procure from MJ Research, 5350 Capital Ct., #103, Reno, Nevada, 89502. A Real-time PCR - DNA Engine Opticon 1 System (single wavelength) to include Opticon 1 continuous fluorescence detector, DNA Engine Thermal Cycler chassis, and a 96-well Alpha unit that will be utilized by personnel from two different programs in the Biomedical Pathology Section. The system shall be used for: (1) Cellular interactions with Thrombospondin to investigate the mechanisms by which the adhesive glycoproteins TSP1 and TSP2 regulate tumor growth, metastasis, and angiogenesis. Accurate methods are required to validate each of these targets and to define the conditions that control expression of their mRNAs; (2) Host Colonization and Vascular Dissemination of Candida albicans to provide information regarding the regulation of an essential gene in the human pathogenic fungus, C. albicans. This protein will be used as a target to develop new antifungal drugs that may provide a new class of clinical reagents. Precise knowledge of the regulation of this gene is necessary to establish at what stages during infection the gene is required. A continuous fluorescence detection system is required that utilizes a Peltier thermal cycler with multi-sensor/multi-zone temperature control technology, thermal accuracy of 0.3C, well-to-well uniformity of 0.4C, accommodating 96 samples, in plate or strip tube format, with programming of a thermal gradient of up to 24C, across the 96-well sample block (12 columns of different temperatures), yielding less than 0.4C variation from the predicted temperature. It also must have the capability to excite samples sequentially with 96 LEDs, and detect each signal via a photomultiplier tube (PMT) individually, without any moving parts, in order to ensure robustness of data collection. The DNA Engine Peltier thermal cycler manufactured by MJ Research meets these requirements and is currently the only technology with "Real-time PCR". This is not a request for quotation. However, if any interested party believes it can meet the above requirements, it may submit a statement of capabilities. The capability statement and any other furnished information must be in writing and must contain material in sufficient detail to allow NCI to determine if the party can fully meet the requirements. Capability statements must be received in the contracting office by 1:00 PM, EST (local Washington, D.C. time) on September 12, 2003. If you have any questions, please contact Malinda Holdcraft, Purchasing Agent via electronic mail at holdcram@exchange.nih.gov or by fax 301-402-4513. A determination by the Government not to compete this proposed requirement based on responses to this notice is solely within the discretion of the Government. Information received shall be considered solely for the purpose of determining whether to conduct a competitive procurement. No collect calls will be accepted. NAICS 334516.
- Place of Performance
- Address: NIH/NCI
- Zip Code: 20892
- Country: USA
- Zip Code: 20892
- Record
- SN00413438-W 20030829/030827213339 (fbodaily.com)
- Source
-
FedBizOpps.gov Link to This Notice
(may not be valid after Archive Date)
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