SOLICITATION NOTICE
A -- Studies of Chemical Disposition in Mammals
- Notice Date
- 1/14/2004
- Notice Type
- Solicitation Notice
- Contracting Office
- Department of Health and Human Services, National Institutes of Health, National Institute of Environmental Health Sciences, Research Contracts Branch, DERT P.O. Box 12874, 79 T.W. Alexander Dr, Bldg 4401, RTP, NC, 27709
- ZIP Code
- 27709
- Solicitation Number
- NIH-ES-04-01
- Response Due
- 3/19/2004
- Archive Date
- 4/3/2004
- Point of Contact
- David Sedgley, Contract Specialist, Phone (919)541-4027, Fax (919)541-2712, - JoAnn Lewis, Contract Officer, Phone 919-541-7894, Fax 919-541-2712,
- E-Mail Address
-
sedgley@niehs.nih.gov, lewisj@niehs.nih.gov
- Description
- The National Institute of Environmental Health Sciences (NIEHS) is soliciting offers for a contract to study the chemical disposition in mammals. The purpose of the project is to obtain detailed chemical disposition data from 3 to 6 studies of selected environmental contaminants or model compounds per year. Most of these studies will be required in laboratory rats (Fischer 344) and/or mice (B6C3F1); however, some studies may require other laboratory animals (other rodent species or dogs). Most of the studies will address the disposition of organic chemicals or environmental contaminants; however, studies of inorganic chemicals may also be requested. Individual studies may vary in complexity from preliminary investigations of chemical absorption to detailed studies of all phases of chemical disposition, toxicokinetics, and metabolism. The immediate goal of these studies is to determine more accurately the doses for National Toxicology Program (NTP) bioassay studies. The long range goal is the accumulation of data that will permit a better assessment of structure-activity for chemical absorption, metabolism and disposition in laboratory animals and to better interpret the significance of these data to man. A study shall consist of the determination of absorption, distribution, metabolism and excretion of a selected compound in a given species. Identification of unknown metabolites may be complex enough to be considered a separate study. Estimation of toxicokinetic parameters may be requested for selected chemicals. One or more studies per year may be requested to investigate the comparative metabolism of chemicals in human and rat liver microsomes or hepatocytes in vitro. The compounds for study shall be selected and provided by the Project Officer. Unless a satisfactory analytical procedure is available for unlabeled compounds and both parties agree to its use, radio labeled compounds shall be provided to facilitate the assay. In most instances, the initial studies shall be performed in male rats; however, the Project Officer shall reserve the right to require studies in female rats or additional species. Male animals are studied initially to avoid the influence of estrogenic hormones on xenobiotic metabolizing enzymes. The protocol for the study shall be developed by the Principal Investigator in cooperation with the Project Officer. The government estimates that the project will require the work of 2 professional man-years and 3 technical/administrative personnel man-years in each contract year. The Principal Investigator and Co-Principal Investigator shall have a minimum of 5 years Post-Doctoral Degree experience. The estimated annual level of effort is 9,980 labor hours. Award of one cost-reimbursement, level of effort contract (the work on the contract involves continuous activity with no clearly defined end point) on an open competition basis is contemplated as a result of this solicitation. The contract obtained under this solicitation will continue the work of a similar contract. The period of performance for the contract is five years, beginning on or about October 1, 2004 through September 30, 2009. Interested organizations should telefax a request for RFP NIH-ES-04-01 to the attention of Mr. David Sedgley, Contract Specialist at (919) 541-2712 or send an e-mail request to sedgley@niehs.nih.gov. The electronic version of the Fed Biz Ops synopsis will be available on the Internet at: http://www.niehs.nih.gov/dert/rcb/rfp.htm. An electronic copy of the RFP (without the NTP Specifications) will be posted to this site on or about January 29, 2004. All responsible sources may submit a proposal which shall be considered by the Agency. Expected release date of the RFP is January 29, 2004 with proposals due March 19, 2003. This requirement is unrestricted. NAICS Code is 541710.
- Record
- SN00503633-W 20040116/040114211917 (fbodaily.com)
- Source
-
FedBizOpps.gov Link to This Notice
(may not be valid after Archive Date)
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