SPECIAL NOTICE
A -- Indolicidin Derivatives: Potent Inhibitors of HIV-1 Integrase For Treatment of Retroviral Infection and HIV
- Notice Date
- 1/11/2005
- Notice Type
- Special Notice
- NAICS
- 541710
— Research and Development in the Physical, Engineering, and Life Sciences
- Contracting Office
- Department of Health and Human Services, National Institutes of Health, National Cancer Institute, Bldg 427, Room 12, Frederick, MD, 21702
- ZIP Code
- 21702
- Solicitation Number
- Reference-Number-SF-INDO-01
- Description
- The National Cancer Institute (NCI) seeks a Cooperative Research and Development Agreement (CRADA) collaborator to develop a series of short peptides derived from indolicidin. These peptides exhibit potent anti-retroviral activity by inhibiting HIV-1 integrase and possess higher antiviral and anti-integrase activity than indolicidin itself. Potential Commercial Applications: Treatment of retroviral infections such as AIDS. These compounds may be used alone, or in combination with other anti-viral therapies directed at other viral targets such as protease and reverse transcriptase. Main Advantages of the Technology: Potential for high clinical utility since HIV-1 integrase is essential for viral replication and no counterpart exists in mammalian cells. Current State of Development: Testing of tetrameric peptides show that these oligomers inhibit the action of integrase at nanomolar concentrations. Further R&D Required: Enhancing the transport properties of the current agents Evaluating toxicology and efficacy in vivo. Patent Status: Three U.S. Patent Applications filed 1/06/2004, 2/25/2004, and 8/10/2004 Pertinent References: Krajewski K, et al. Bioorg Med Chem Lett. 2004 Nov 15;14(22):5595-8. Krajewski K, et al. Bioorg Med Chem Lett. 2003 Oct 6;13(19):3203-5. Contact Information: CRADA Contact: Steven C. Fausch, Ph.D., Technology Transfer Branch, NCI Phone: 301-846-5222; E-mail: fauschs@mail.nih.gov Licensing Contact: Sally Hu, Ph.D., M.B.A., Office of Technology Transfer, NIH Phone: 301-435-5606; E-mail: hus@mail.nih.gov
- Record
- SN00732863-W 20050113/050111211632 (fbodaily.com)
- Source
-
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