SOURCES SOUGHT
A -- Request for Proposal
- Notice Date
- 6/14/2006
- Notice Type
- Sources Sought
- NAICS
- 325412
— Pharmaceutical Preparation Manufacturing
- Contracting Office
- Department of Health and Human Services, National Institutes of Health, National Cancer Institute, Bldg 427, Room 12, Frederick, MD, 21702
- ZIP Code
- 21702
- Solicitation Number
- S06-040A
- Archive Date
- 8/16/2006
- Description
- We wish to obtain one or more of 22 steroids (named below) labeled with a stable isotope as specified in the following paragraphs. Also of interest are glucuronide or sulfate conjugates of these steroids that meet the specifications outlined. We wish to obtain at least 0.1 g of each labeled steroid. To be consistent, capitalize the first letter of each steroid even if following a number. Estrone, 17B-Estradiol, 2-Hydroxyestrone, 2-Hydroxyestradiol, etc. Compounds supplied under this solicitation shall meet the following criteria. 1) The molecular weight (MW) of each supplied sample must be at least 3 Da greater than that of the natural material. 2) A full mass spectrum shall be provided confirming that no more than 2% of the total mass appears at MWs smaller than that of the natural material plus 3. 3) A full mass spectrum shall be provided confirming that no more than 2% of the total mass appears at MWs smaller than that of the natural material plus 2% after dissolution in pH 9 aqueous medium for 10 minutes at 60 degrees C. To confirm satisfactory chemical purity, samples provided under this solicitation shall be accompanied by HPLC traces with UV or ideally evaporative light scattering detection. We prefer the glucuronide and sulfate conjugates to have the stable isotope incorporated into the steroid nucleus rather than the glucuronide or sulfate residue; however, offers of compounds with the label in the glucuronide or sulfate moiety will be considered. We wish to obtain 0.1 g of each compound; however, offers of smaller quantities will be considered. Our highest priority is to obtain any one or more of 22 steroids (named below) wherein the steroid is substituted with stable isotopes as specified in the following paragraphs. Also of potential interest are glucuronide or additional sulfate conjugates of these steroids that meet the specifications outlined. List of 22 Steroids Estrone; 17B-Estradiol; 2-hydroxyestrone; 2-hydroxyestradiol; 4-hydroxyestrone; 4-hydroxyestradiol; 16a-hydroxyestrone; 16-keto-17B-estradiol; 2-methoxyestrone; 2-methoxyestradiol; 2-hydroxyestrone-3methyl ether; 4-methoxyestrone; Estriol; 16-epiestriol; 17-epiestriol; Estrone-3-sulfate; Progesterone; Testosterone; Androstenedione; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; 4-Methoxyestradiol Offerors shall provide the structure, including the specific labeling pattern, of the compound(s) that will be supplied. Offerors may propose to provide one or more of the desired compounds. Likewise, contracts may be awarded to multiple offerors for the provision of one or more of the compounds.
- Place of Performance
- Address: Subcontractor's facility
- Record
- SN01069292-W 20060616/060614220503 (fbodaily.com)
- Source
-
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