SOLICITATION NOTICE
A -- ToxCast Prioritization of Environmentally Relevant Chemicals: (P#2) Bioactivity Profiling of the ToxCast Compound Library
- Notice Date
- 9/13/2006
- Notice Type
- Solicitation Notice
- Contracting Office
- Bid and Proposal Room, Ariel Rios Building (3802R) 1200 Pennsylvania Avenue, N.W. Washington, DC 20460
- ZIP Code
- 20460
- Solicitation Number
- PR-HQ-06-15840
- Response Due
- 9/27/2006
- Archive Date
- 12/31/2006
- Small Business Set-Aside
- N/A
- Description
- The following is an announcement for a Pre-Solicitation Conference, which will be held for the NCCT TOXCAST PROGRAM procurement entitled "ToxCast Prioritization of Environmentally Relevant Chemicals: (P#2) Bioactivity Profiling of the ToxCast Compound Library." This procurement is the EPA's second attempt at soliciting proposals for the work described in the performance work statement. The previous Request for Proposal (RFP) # PR-HQ-06-14708 was entitled "ToxCast Prioritization of Environmentally Relevant Chemicals: (P#2) Gene Family Panel Screening of the ToxCast Compound Library." That RFP was canceled by the EPA on August 31st. Based on the results of the first solicitation, the Agency has revised several aspects of the procurement and will re-solicit the work under the RFP # PR-HQ-06-15840. The Pre-Solicitation Conference will be held on September 27, 2006 at 12:30 PM (ET) at U.S. EPA, Office of Research and Development (ORD) Conference Room (4th Floor Lobby, Room #s ORMA Conf. Rm. 1 & 2), Ronald Reagan Building and International Trade Center, 1300 Pennsylvania Avenue, Washington, D.C., 20004. Information on the conference is available on EPA?s web page at: http://www.epa.gov/oamhpod1/admin_placement/0615840/index.htm. The EPA encourages all interested parties and potential offerors to attend the conference. Draft documents, including the performance work statement, the contract line items, the solicitation/contract specialized clauses and the solicitation evaluation criteria, have been made available on the web page. The EPA anticipates that the procurement will be procured using FULL AND OPEN COMPETITIVE PROCEDURES. THE APPLICABLE NAICS CODE IS 541710. Please e-mail the Contracting Officer at "nanartowicz.john@epa.gov" by September 25th to express your interest in attending the conference and to comment on any of the draft documents. BACKGROUND: The Environmental Protection Agency, Office of Research and Development established the National Center for Computational Toxicology (NCCT) in 2005 to research the utility of computational chemistry, high-throughput screening (HTS) and various toxicogenomic technologies for Agency use in chemical prioritization, quantitative risk assessment and biological modeling. As part of this, the NCCT is developing computational tools for interpreting data from these technologies to classify chemicals, predict toxicity, and prioritize limited testing resources towards chemicals and endpoints that present the greatest risk to human health and the environment. Thus a chemical prioritization research program, entitled ToxCast, is being initiated with the purpose of developing the ability to predict, or forecast toxicity. The proof-of-concept phase of ToxCast will focus upon chemicals with a rich toxicological database (e.g., registered pesticide actives), in order to provide an interpretive context. Following this proof-of-concept, the ToxCast program will move on to other environmental chemicals domains relevant to EPA. The ToxCast program will evaluate chemical properties and effects across a broad spectrum of information domains: physical-chemical properties, predicted biological activities based on existing structure-activity models, biochemical properties based on HTS assays, cell based phenotypic assays, and genomic and metabolomic analyses of cells. SCOPE: Much of the data in these various domains will be generated through a series of seven (7) integrated Performance Work Statements (PWS). The contracts that may be awarded from this re-solicitation effort will be an essential component of the ToxCast program over the next five years, providing data populating the various domains that can be interpretively linked to known or predicted toxicological properties of environmental chemicals.
- Web Link
-
The Environmental Protection Agency
(http://www.epa.gov/oam/solicit)
- Record
- SN01142793-W 20060915/060913222157 (fbodaily.com)
- Source
-
FedBizOpps Link to This Notice
(may not be valid after Archive Date)
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