Loren Data's SAM Daily™

FBO DAILY ISSUE OF NOVEMBER 15, 2006 FBO #1815
SOURCES SOUGHT

A -- Preparation of Antisera against Recombinant PA Protein in Rabbits

Notice Date

11/13/2006
 

Notice Type

Sources Sought
 

NAICS

541690 — Other Scientific and Technical Consulting Services
 

Contracting Office

US Army Medical Research Acquisition Activity, ATTN: MCMR-AAA, 820 Chandler Street, Frederick, MD 21702-5014
 

ZIP Code

21702-5014
 

Solicitation Number

W81XWH-RAA-01
 

Response Due

11/27/2006
 

Archive Date

1/26/2007
 

Small Business Set-Aside

N/A
 

Description

THIS IS NOT A SOLICITATION ANNOUNCEMENT. THIS IS A SOURCES SOUGHT SYNOPSIS ONLY. THE PURPOSE OF THIS SOURCES SOUGHT SYNOPSIS IS TO GAIN KNOWLEDGE OF POTENTIAL QUALIFIED SOURCES FOR PLANNING PURPOSES ONLY FOR THE U.S. ARMY MEDICAL MATERIEL DEVELOPMENT ACTIVITY (USAMMDA), FORT DETRICK, MARYLAND. USAMRIID is seeking a Contract Research Organization (CRO) to conduct the enclosed Statement of Work. However, this announcement is not a formal solicitation and is not a request for proposal. No contract wil l be awarded from this announcement. No reimbursement will be made of any costs to provide information in response to this announcement or any follow up information requests. Availability of any formal solicitation will be announced under a separate anno uncement. This synopsis is for information and planning purposes only and is not to be construed as a commitment by the Government. Each response must reference the sources sought title. All proprietary information should be marked as such. Responses w ill be held confidential if requested. Please submit fact sheets to the attention of: USAMMDA, ATTN: MCMR-UMP, 622 Neiman Street, Fort Detrick, MD 21702-5009. Fact sheets may be emailed to: Scott.Doughty@DET.AMEDD.ARMY.MIL. Responses must be received no l ater than 27 November 2006, by 4:00 P.M. Eastern Standard Time. STATEMENT OF WORK Schedule and Requirements for the Preparation of Antisera against Recombinant PA Protein in Rabbits 1. Purchase of 74 New Zealand White rabbits (37 female and 37 male) at 2.7-3.1 kg each. Rabbits will be identified with a unique identifier. 2. Pre-bleed 74 rabbits. 3. Primary (1?) intramuscular (IM) injection of 74 rabbits at week 0 according to the table. 10 rabbits injected with 10 ?g of rPA/Alhydrogel 10 rabbits injected with 1 ?g of rPA/Alhydrogel 40 rabbits injected with 0.1 ?g of rPA/Alhydrogel 10 rabbits injected with 0.01 ?g of rPA/Alhydrogel 4 rabbits injected with PBS/Alhydrogel 4. Bleed rabbits for 5 ml of serum (test bleed) after primary injection according to schedule in the table. Total of 134 bleedings. 5. Booster (2?) IM injection of 74 rabbits at week 2, 4, 12, or 24 according to the schedule in the table. At week 2; inject 10 rabbits with 10 ?g of rPA/Alhydrogel inject 10 rabbits with 1 ?g of rPA/Alhydrogel inject 10 rabbits with 0.1 ?g rPA/Alhydrogel inject 10 rabbits with 0.01 ?g of rPA/Alhydrogel inject 4 rabbits with PBS/Alhydrogel. At week 4; inject 10 rabbits with 0.1 ?g of rPA/Alhydrogel. At week 12; inject 10 rabbits with 0.1 ?g of rPA/Alhydrogel. At week 24; inject 10 rabbits with 0.1 ?g of rPA/Alhydrogel. 6. Production bleed (~25 ml) rabbits two weeks after the booster injection according to the schedule in the table. Total of 74 bleedings. After the production bleed, rabbits will be euthanized. 7. Approximate length of time rabbits will be on study; 44 rabbits for 30 days 10 rabbits for 44 days 10 rabbits for 100 days 10 rabbits for 184 days Table 1. Schedule of injections and bleedings for rabbits. Group # # Rabbits Pre-bleed 1? rPA (?g) Bleed Post 1? rPA Booster 2? rPA (?g) Bleed Post 2? Days on study 1 10 Y 10 Wk 2 Wk 2 10 Wk 2 30 2 10 Y 1 Wk 2 Wk 2 1 Wk 2 30 3 10 Y 0.1 Wk 2 Wk 2 0.1 Wk 2 30 4 10 Y 0.1 Wk 2, 4 Wk 4 0.1 Wk 2 44 5 10 Y 0.1 Wk 2, 4, 12 Wk 12 0.1 Wk 2 100 6 10 Y 0.1 Wk 2, 4, 12, 24 Wk 24 0.1 Wk 2 184 7 10 Y 0.01 Wk 2 Wk 2 0.01 Wk 2 30 8 4 Y 0 Wk 2 Wk 2 0 Wk 2 30 , the same concentration of rPA will be injected IM for the primary (1?) and booster (2?) injections at the stated intervals. Original Point of Contact Rebecca J. Tama 301-619-2381 Email your questions to US Army Medical Research Acquisition Activity at Rebecca.Tama@AMEDD.ARMY.MIL
 

Place of Performance

Address: US Army Medical Research Acquisition Activity ATTN: MCMR-AAA, 820 Chandler Street Frederick MD

Zip Code: 21702-5014

Country: US
 

Record

SN01180192-W 20061115/061113220538 (fbodaily.com)
 

Source

FedBizOpps Link to This Notice
(may not be valid after Archive Date)

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