SPECIAL NOTICE
A -- In-Vivo Assessment of Microbicide Efficacy and Immunologic Impact of Interventions on Pig-tail Macaues
- Notice Date
- 4/2/2007
- Notice Type
- Special Notice
- NAICS
- 541710
— Research and Development in the Physical, Engineering, and Life Sciences
- Contracting Office
- Department of Health and Human Services, Center for Disease Control and Prevention, Procurement and Grants Office (Atlanta), 2920 Brandywine Road, Room 3000, Atlanta, GA, 30341-4146, UNITED STATES
- ZIP Code
- 00000
- Solicitation Number
- 2007-Q-09474
- Response Due
- 4/11/2007
- Archive Date
- 4/26/2007
- Description
- Title: In-Vivo Assessment of Microbicide efficacy and Immunologic Impact of Interventions on Pig-Tail Macaques The Centers for Disease Control and Prevention, National Center for HIV, Hepatitis, STD, and Tuberculosis Prevention intends to negotiate and issue a sole source award under Simplified Acquisition procedures to Emory/Yerkes National Primate Research Center, 954 Gatewood Road, Atlanta, GA 30322 for 9 female Pig-tail Macaques required for studies in preventing HIV transmission. The purpose of this study will be to develop an assay or combination of methods to examine/evaluate potential mucosal factors that inhibit HIV-infection. This study is a follow-up to previous year studies and requires pig-tail macaques to ensure comparable data sets across studies. CDC will enroll the Female Pig-tail Macaques in this pre-clinical, topical microbicide intervention study to evaluate soluble DC-SIGN for the prevention of mucosal SHIV transmission in a repeat challenge macaque model of HIV-infection, evaluate the immunologic kinetics at peripheral and mucosal sites, evaluate combination topical microbicide/oral ARV intervention to block SHIV infection in a repeat-exposure macaque model of HIV-1 infection, and conduct a retrospective evaluation of immunologic kinetics in oral TDF-treated macaques that were part of a rectal transmission study. The vendor shall test and transport to CDC 9 female pig-tail macaques in accordance with federal regulations for research animal use and care. The period of performance is 12 months from date of award. This is not a request for competitive proposals and no solicitation is available. A determination by the Government not to compete this proposed action based on response to this notice is solely with the discretion of the Government. Interested parties who believe they possess the capabilities to satisfy this requirement should submit a capability statement demonstrating their abilities to meet this requirement. Responses should be received by the closing date of the synopsis. Contractors must be registered in the Central Contractor Registration (CCR). Contractors may register by calling 1-888-227-2423 or register via the Internet at www.ccr.gov. Registration Notification of any changes shall be made only through FedBizOpps, http://ww.fedbizopps.gov. Capability statements may be faxed to (404) 639-8095, ATTN: Ms. Johnson or emailed to chj5@cdc.gov. No phone calls will be accepted. The date specified for receipt (closing date)is April 11, 2007, 9:00 a.m. EST.
- Place of Performance
- Address: Department of Health and Human Services, Center for Disease Control and Prevention, Procurement and Grants Office (Atlanta), 2920 Brandywine Road, Room 3000, Atlanta, GA
- Zip Code: 30341-4146
- Country: UNITED STATES
- Zip Code: 30341-4146
- Record
- SN01264184-W 20070404/070402220242 (fbodaily.com)
- Source
-
FedBizOpps Link to This Notice
(may not be valid after Archive Date)
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