SOLICITATION NOTICE
A -- Repository of Mouse Models for Cytogenetic Disorders
- Notice Date
- 3/18/2010
- Notice Type
- Presolicitation
- NAICS
- 541711
— Research and Development in Biotechnology
- Contracting Office
- Department of Health and Human Services, National Institutes of Health, National Institute of Child Health and Human Development, Contracts Management Branch, 6100 Executive Blvd., Suite 7A07, MSC7510, Bethesda, Maryland, 20892-7510
- ZIP Code
- 20892-7510
- Solicitation Number
- NIH-NICHD-CDBPM-10-11-PS
- Point of Contact
- Katharine Minker, Phone: 301-402-7571, Louis Kuta, Phone: 301-435-6965
- E-Mail Address
-
km571h@nih.gov, lk240k@nih.gov
(km571h@nih.gov, lk240k@nih.gov)
- Small Business Set-Aside
- N/A
- Description
- The Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), Center for Developmental Biology & Perinatal Medicine (CDBPM) has a requirement for a repository to develop and maintain mouse models of genetic diseases. The objective of this contract will be to produce, maintain, and distribute aneuploid mice with a primary emphasis on chromosome 16 as a model of human trisomy for chromosome 21. If selected for this requirement, the Contractor will breed mice and refine methodologies to produce the various strains of mice and to maintain their genetic fidelity. The work will involve the following essential activities: 1) Maintenance of the “Repository for Mouse Models of Cytogenetic Disorders” or “Cytogenetic Resource”. 2) Breed various strains of mice with known genetic background, which will produce chromosomally unbalanced gametes, resulting in trisomic and monosomic embryos with special emphasis on chromosome 16, but including relevant regions of chromosome 17 and chromosome 10. 3) Refine procedures to cryopreserve embryos that will be rescued by thawing and re-implanting them in pseudo-pregnant mice. 4) Distribute the animal models to qualified investigators approved by the NICHD. 5) Test the animals periodically for pathogens. 6) Publicize the availability of mouse models indicating the type of strains in the colony as well as detailed information about the strain phenotype, genotype, protocols for genotyping, husbandry conditions, and other details as specified by the Project Officer. 7) Characterize the clinical and behavioral phenotype of the mouse models to ensure integrity of the strains, especially for any new strains offered by the Contractor or as specified by the Project Officer. As a result of this announcement the NICHD anticipates awarding a single cost reimbursement completion type contract with a period of performance of five years beginning on or about July 1, 2010. The NICHD anticipates the Request for Proposals (RFP) for this study will be available through the Federal Business Opportunities website (https://www.fbo.gov/) on or about April 5, 2010. This acquisition has been designated as a full and open competition under North American Industry Classification System (NAICS) code is 541711 with a size standard of 500 employees. Any responsible offeror may submit a proposal that will be considered by the Government. This notice does not commit the Government to award of a contract. No collect calls or facsimile transmissions will be accepted.
- Web Link
-
FBO.gov Permalink
(https://www.fbo.gov/spg/HHS/NIH/NICHD/NIH-NICHD-CDBPM-10-11-PS/listing.html)
- Record
- SN02096785-W 20100320/100318235608-72e3b993b46253f525f999e6e454bbf7 (fbodaily.com)
- Source
-
FedBizOpps Link to This Notice
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