SOLICITATION NOTICE
66 -- Carl Zeiss LSM 710 Confocal Microscope and components
- Notice Date
- 3/24/2010
- Notice Type
- Presolicitation
- NAICS
- 334516
— Analytical Laboratory Instrument Manufacturing
- Contracting Office
- Department of Health and Human Services, National Institutes of Health, National Cancer Institute, Office of Acquisitions, 6120 Executive Blvd., EPS Suite 600, Rockville, Maryland, 20852
- ZIP Code
- 20852
- Solicitation Number
- NCI-100049-KM
- Archive Date
- 4/23/2010
- Point of Contact
- Karri L. Mares, Phone: 3014357774, Caren N Rasmussen, Phone: (301) 402-4509
- E-Mail Address
-
maresk@mail.nih.gov, cr214i@nih.gov
(maresk@mail.nih.gov, cr214i@nih.gov)
- Small Business Set-Aside
- N/A
- Description
- General Information Document Type: Presolicitation Solicitation Number: NCI-100049-KM Proposed Posted Date: 3/24/2010 Proposed Response Date: 4/8/2010 11 AM EST Classification Code: 66 – Instruments and Laboratory Equipment NAICS Code: 334516 Analytical Laboratory Instrument Manufacturing Business Size Standard: 500 employees Contracting Office Address Department of Health and Human Services, National Institutes of Health, National Cancer Institute, Office of Acquisitions, 6120 Executive Boulevard, EPS Suite 600, Room 6070, Rockville, MD 20852, UNITED STATES. The National Cancer Institute (NCI), Center for Cancer Research (CCR), plans to procure on a sole source basis the brand name Carl Zeiss LSM 710 Confocal Microscope to include: 1) 405 cw Laser Kit; 2) Software package: Physiology & Multi-time 2009; 3) NLO System table; 4) Switching Mirror MOT 2x, T-PMT; 5) T-PMT for LSM 710; 6) Axio Examiner upper part; 7) Tube-Aurora LSM mot; 8) Tube for fixed stage; 9) Shutter mot f/TL; 10) illumination; 11) Cable set Axio Examiner; 12) Dust protection set for Axio Examiner; 13) Connection PCB f/mot Com. Upper part; 14) Diaphragm Slider man w/Luminous Field; 15) Axio Examiner optics for epifluorescence; 16) Shutter mot f/RL illumination; 17) Filter Wheel 6x f/FL attenuation; 18) Diaphragm Slider man w/Luminous Field; 19) X-Cite 120Q IRIS FL LT Source; 20) Contact Kit Laser Safety Illum; 21) Eyepiece PL 10x23 Br foc; and 22) APO Calibration LSM M27 with Carl Zeiss Microimaging, One Zeiss Drive, Thornwood, NY, 10594. The North American Industry Classification System (NAICS) Code for this procurement is 334516 and the business size standard is 500 employees. This acquisition will be processed in accordance with simplified acquisition procedures as stated in FAR Part 13.106-1(b)(1). Delivery shall be in 45 days upon receipt of purchase order. Only one award will be made as a result of this solicitation. This will be awarded as a firm fixed price type contract. The purpose of this acquisition is to procure and install a Carl Zeiss LSM 710 Confocal Microscope system for the specific purpose of understanding the role of novel metastasis-associated genes and in defining mechanisms of actions for novel therapeutics in vivo. Carl Zeiss LSM 710 Confocal Microscope is proprietary to Carl Zeiss Microimaging. This instrument is necessary for the Tumor and Metastasis Biology Section (TMBS), Pediatric Oncology Branch to optimally image the process of metastasis in vivo (i.e. in mice) at the level of the single cells. This new LSM 710 is the only microscope able to acquire, analyze, and 3D render images in a rapid scanning manner, needed for live animal imaging of metastasis. The flexibility of the system, and the associated service team, will allow in-site two-photon confocal expansion and on-site trouble shooting. The new software ZEN has real time electronics communication with PC for data storage via gigabit Ethernet connection. View modes allow off line data management of previously collected images possible while scanning. This system has the only computing hardware and software design that does not limit use of system so that analysis of data can proceed without harmful delays in image acquisition within the time frame needed for these studies. The salient characteristics that apply to the Carl Zeiss LSM 710 Confocal Microscope are: 1. Must incorporate Primary Dichroioc Beam Splitter (Twin Gate) which achieves extremely High laser suppression, on the order of 6-7 OD, allowing superb reflection free imaging. The system omits all secondary dichroics for high efficiency emission collection. 2. Must provide free selection of emission bands for detection, omitting secondary dichroics or emission filters. It must be possible to set the emission bands over laser lines due to effective laser blocking to insure full photon collection. 3. Must have real time electronics - Communication with PC for data storage operates via gigabit Ethernet connection. View modes- allows off line data management of previously collected images possible while scanning. Extremely powerful hardware and software design as data collection does not limit use of system so that valuable time can be spent analyzing data without wait time on image acquisitions. 4. Must have a customized user interface for users that must allow User-specific Workspace setups can be stored within the software according to the users needs and application. 5. Must provide self-test tool, with an easy to use maintenance user interface. In combination with a calibration objective that allows automated pinhole adjustment and automatic scanner calibration, securing optimal system performance. 6. Freely rotatable scan field (0-360 degree in 0.1° steps) with user definable size and shape due to independent galvo-mirrors. Allows for independent positioning of specimen on stage that is very important for whole animal experiments in which there is little control over orientation on the stage. Allows complete freedom when scanning. 7. System must support at least 10 or more pixel dwell times for various experimental conditions. Very important for the diverse endogenous signal strengths that will be presented to the detectors. 8. Laser Scanning Microscope must be able to support different pixel dwell times between imaging and uncaging modes in the same experiment. 9. Point Scanner should be able to reach > 7F/S at 512X512. 10. Confocal Lasers must be coupled "mirror free" so they DO NOT NEED alignment repeatedly in the field. Required for stability of the output on the system for our quantitative experiments. Lasers should be plug-and-play. 11. Two-photon upgradability of this system. 12. System must include Fixed Stage Microscope with at least 4 position manual encoded Objective turret, NDD light Path for 2P upgradability, motorized 5 position filter turret, Upgradability to GaAsp detection at exit pupil of objective, must include transmitted light path. 13. Upto 6KX6K scanning at 8, 12 or 16 bit digitization. 14. Transmitted light detector capable of imaging simultaneously with the Laser scanning microscope with all fluorescence images. This is not a request for competitive quotation. However, if any interested party believes it can meet the above requirement, it may submit a statement of capabilities. The statement of capabilities and any other information furnished must be in writing and must contain material in sufficient detail to allow the researcher to determine if the party can perform this requirement. An original and one copy of the capability statement must be received in the Office of Acquisitions at the address stated above on or before 11:00 am ET on April 8, 2010 to Karri Mares, Contract Specialist. No electronic capability statements will be accepted (i.e. email or fax). All questions must be in writing and can be faxed to 301-402-4513 or sent via email to maresk@mail.nih.gov. It is the vendor’s responsibility to ensure questions have been received. A determination by the Government not to compete this proposed requirement based upon responses to this notice is solely within the discretion of the Government. Information received will be considered solely for the purpose of determining whether to conduct a competitive procurement. No collect calls will be accepted. In order to receive an award, contractors must be registered in and have valid certifications in the Central Contractor Registration (CCR), www.ccr.gov and the Online Representations and Certifications Application (ORCA) www.orca.bpn.gov. Please reference NCI-100049-KM on all correspondence.
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