SOLICITATION NOTICE
R -- Professional Services for Prostate Cancer Study
- Notice Date
- 8/17/2011
- Notice Type
- Presolicitation
- NAICS
- 541720
— Research and Development in the Social Sciences and Humanities
- Contracting Office
- Department of Health and Human Services, National Institutes of Health, National Heart, Lung and Blood Institute, Rockledge Dr. Bethesda, MD, Office of Acquisitions, 6701 Rockledge Dr RKL2/6100 MSC 7902, Bethesda, Maryland, 20892-7902
- ZIP Code
- 20892-7902
- Solicitation Number
- NHLBI-CSB-(HG)-2011-308-DLM
- Archive Date
- 9/6/2011
- Point of Contact
- Dorothy Maxwell, Phone: 301-435-0352
- E-Mail Address
-
maxwelld@mail.nih.gov
(maxwelld@mail.nih.gov)
- Small Business Set-Aside
- N/A
- Description
- THIS IS A NOTICE OF INTENT, NOT A REQUEST FOR A PROPOSAL. A SOLICITATION DOCUMENT WILL NOT BE ISSUED AND PROPOSALS WILL NOT BE REQUESTED. The National Heart, Lung, and Blood Institute (NHLBI) Office of Acquisition (OA) intends to negotiate and award a purchase order on a noncompetitive sole source basis Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, Pennsylvania 19111-2497 to provide professional services to the researchers for the Finnish Prostate Cancer, African American Hereditary Prostate Cancer (AAHPC) and the Autism Sequencing studies. The sole source determination is based on the fact that the National Institutes of Health (NIH) is the nation's leading medical research agency and the primary Federal agency conducting, supporting and making medical discoveries that improve people's health and save lives. The National Human Genome Research Institute (NHGRI), Division of Intramural Research's (DIR) overall mission is to develop and implement technology for the rapid isolation, analysis, and treatment of genetic diseases. The Division=s research laboratories and clinical branches develop and use the most advanced techniques to study the fundamental mechanisms of inherited and acquired genetic disorders. Research also includes planning and conducting clinical trials to test DNA-based methods for treatment and perhaps the cure of such diseases. Researchers collect and study families in which important diseases are inherited, as well as translate basic science advances into effective, reliable, and cost effective DNA and cytogenetic-based diagnostics. This study will be performed under existing collaborative efforts NIH/NHGRI Protocol Number: 0H95-HG-N0158 Genetic Analysis of Hereditary Prostate Cancer and 10-CH-0022 Exome Sequencing in Autism Spectrum Disorder. PURPOSE AND OBJECTIVE : The purpose of this procurement is to provide professional services to the researchers dedicated to the studies. These services will be in the areas of providing statistical genetic analyses for the Finnish Prostate Cancer study, the AAHPC study and the Autism Sequencing study. The Contractor will work with the Co-Branch Chief of Inherited Disease Research Branch (IDRB), NHGRI to perform linkage and association analyses of prostate cancer in human pedigree data. The Contractor will be involved in this large collaborative effort to identify, isolate and characterize currently unknown genes for this disease. NHGRI plans additional analyses in the Finnish families and AAHPC families, analyses of new data in the Autism Sequencing study and meta analyses of existing and new data. The Contractor's contributions to the analyses of these data are critical. The Contractor will also work with IDRB to write papers presenting the results of meta-analyses from the AAHPC data and African-American families provided by the collaborators in the International Consortium on Prostate Cancer Genetics (ICPCG). These studies would be unacceptably negatively impacted if The Contractor was not available to work on the Finnish prostate cancer project and the AAHPC project. The Finnish Prostate Cancer study is a major collaboration between investigators at NIH and in Finland who have collected high-risk families for prostate cancer and are looking for evidence of genetic susceptibility loci in the families. The AAHPC study is a major collaboration between investigators at NHGRI, Howard University, Translational Genomics Research Institute, and Fox Chase Cancer Center. CONTRACTOR REQUIREMENTS : • The contractor will engage in several activities, including assisting IDRB with construction and checking of pedigree files, checking genotype and trait data for errors (using sophisticated computer programs), estimating allele frequencies, performing linkage and association analyses, and constructing haplotypes to narrow the region where the putative gene may exist. REPORTING REQUIREMENTS AND DELIVERABLES : • The contractor will work with IDRB and other members of the NHGRI on a weekly basis. The Contractor will communicate progress and provide summary of activities, either orally or in writing, to Principal Investigator on a quarterly basis, at a minimum. In actual practice, the Principal Investigator and the contractor will probably be in contact by telephone or email at least on a weekly basis. In addition to the quarterly progress report, the contractor will deliver the data analyses as they are completed. The contractor will meet the principal investigator at a scientific meeting or at the NIH as needed for planning and development of the data analysis efforts. PERIOD OF PERFORMANCE AND LEVEL OF EFFORT : • The overall estimated period of performance for the contract will be twelve months. PROGRAM MANAGEMENT AND CONTROL REQUIREMENTS : • The contractor will work independently with no direct supervision by any government employee. The study Principal Investigator and other research team members will provide guidance in terms of technical reporting needs and study requirements of the project supported, plus frequent email and telephone guidance concerning the design and conduct of the analyses and the interpretation of the results. GOVERNMENT RESPONSIBILITIES : • The contractor will provide their own supplies and space to work. The government will loan necessary PC computer equipment to the contractor in order to ensure that all government data are stored only on government computers and that all government-required security procedures are followed. The contractor will also have access to government-owned high-speed computer servers at NHGRI so that the analyses can be completed in a timely manner in a secure environment. On occasions when collaborative efforts will occur when the contractor is visiting NHGRI, the contractor will have temporary use of government space and computer equipment on an as-needed basis. INSPECTION AND ACCEPTANCE CRITERIA : • As plans are developed the contractor will provide draft documentation, reports, and progress of the work. The Principal Investigator will review, inspect, and approve all documentation to ensure that work is in line and following the objectives of the study. Industry Classification (NAICS) Code is 541720, with size standard of $7.0M. The acquisition is being conducted under FAR Part 13, simplified acquisition procedures, therefore the requirements of FAR Part 6 B Competitive Requirements are not applicable (FAR Part 6.001).and the resultant purchase order will include all applicable provisions and clauses in effect through the Federal Acquisition Circular (FAC) 2005-53 (August 4, 2011). This notice of intent is not a request for competitive proposals. Interested parties may identify their interest and capabilities in response to this synopsis, by August 22, 2011, 7:30 a.m. Eastern Standard Time. The determination by the Government not to compete the proposed contract based upon responses to this notice is solely within the discretion of the Government. Information received will normally be considered solely for the purpose of determining whether to conduct future competitive procurement. Inquires to this announcement, referencing synopsis number NHLBI-CSB-(HG)-2011-308-DLM, may be submitted to the National Heart, Lung and Blood Institute, Office of Acquisition, COAC Services Branch, 6701 Rockledge Drive, Suite 6149, Bethesda, Maryland 20892-7902, Attention: Dorothy Maxwell. Response may be submitted electronically to maxwelld@mail.nih.gov. Faxes will not be accepted. Responses will only be accepted if dated and signed by an authorized company representative. Note: In order to receive an award from the NHLBI, contractors must have a valid registration in the Central Contractor Registration (CCR) www.ccr.gov, and ORCA https://orca.bpn.gov/login.aspx.
- Web Link
-
FBO.gov Permalink
(https://www.fbo.gov/spg/HHS/NIH/NHLBI/NHLBI-CSB-(HG)-2011-308-DLM/listing.html)
- Place of Performance
- Address: NIH, Bethesda, Maryland, 20892, United States
- Zip Code: 20892
- Zip Code: 20892
- Record
- SN02537989-W 20110819/110817235431-dcad6f2f39d7d3c7144fb66e7b2a357a (fbodaily.com)
- Source
-
FedBizOpps Link to This Notice
(may not be valid after Archive Date)
| FSG Index | This Issue's Index | Today's FBO Daily Index Page |