SOLICITATION NOTICE
66 -- Instrument That Allows Measurement of mRNA with High Sensitivity
- Notice Date
- 8/22/2011
- Notice Type
- Combined Synopsis/Solicitation
- NAICS
- 333999
— All Other Miscellaneous General Purpose Machinery Manufacturing
- Contracting Office
- Department of Health and Human Services, National Institutes of Health, National Heart, Lung and Blood Institute, Rockledge Dr. Bethesda, MD, Office of Acquisitions, 6701 Rockledge Dr RKL2/6100 MSC 7902, Bethesda, Maryland, 20892-7902
- ZIP Code
- 20892-7902
- Solicitation Number
- NHLBI-CSB-(AR)-2011-326-CRS
- Archive Date
- 9/13/2011
- Point of Contact
- Caitlin Savina,
- E-Mail Address
-
savinacr@nhlbi.nih.gov
(savinacr@nhlbi.nih.gov)
- Small Business Set-Aside
- N/A
- Description
- Reference Number: NHLBI-CSB-(AR)-2011-326-CRS Title: Instrument That Allows Measurement of mRNA with High Sensitivity THIS IS A COMBINED SYNOPSIS / SOLICITATION NOTICE. This is a combined synopsis / solicitation for commercial items, prepared in accordance with the format of FAR 12.6, as supplemented with additional information included in this notice. This announcement constitutes the only solicitation; quotes are being requested and a written solicitation will not be issued. The reference solicitation number is: NHLBI-CSB-(AR)-2011-326-CRS. This solicitation is issued as a request for quotation (RFQ). This acquisition is being conducted under the procedures in accordance with FAR 13.3 Simplified Acquisition Methods, and FAR Part 13.5 - Test Program for Certain Commercial Items. The resultant purchase order will include all applicable provisions and clauses in effect through the Federal Acquisition Circular 05-53 August 04, 2011. The total contracted dollar amount, including options will not exceed $5 million. The acquisition is being conducted as Full and Open Competition. The North American Classification System (NAICS) code applicable to this requirement is 339999, and the associated small business size standard is 500 Employees. The National Institutes of Health (NIH), National Heart, Lung, and Blood Institute (NHLBI), Office of Acquisitions (OA), on behalf of the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), intends to award a single, fixed priced contract for the purchase of an instrument that allows measurement of mRNA with high sensitivity. Background: The Translational Immunology Section at National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), is critically involved in several studies which requires assessment of the expression levels of genes from cohorts of clinical patients. In order to properly support studies on the genetic basis of autoimmune disease- NIAMS requires technologies that allow high throughput measurement of transcript abundance. This could be achieved via different technologies but, in particular, NIAMS needs an instrument that allows measurement of mRNA with high sensitivity (possible as low as 1 copy of mRNA per cell) and that will be important to be able to assess transcript abundance directly without any amplification step and with a digital readout output. Specifications shall include: Level of Multiplexing Up to - 550 Gene Targets per Assay Recommended Amount of Starting Material -100ng of total RNA, or lysate from ~10,000 cells Sample Types Supported - Total RNA, Cell Lysates in GITC, FFPE derived total RNA and PAXgene lysed whole blood Reaction Volume - 30 μL Limit of Detection -0.5fM spike-in control (~1 copy per cell); 90% of the time Fold Change Sensitivity >1.5 fold (>5 copies per cell)>2 fold change >(1 copy per cell) Linear Dynamic Range - 7 X 105 Total Counts Throughput -12 samples <2.5 hours Digital Analyzer Throughput -12 samples/4 hours (up to 72 samples per day The award will be made to the Offeror whose product meets the Government's minimum performance specifications, functional specifications, and delivery date. A best buy analysis will be performed taking into consideration price, shipping points, technical specifications, special features, trade-in considerations, probable life of the item selected as compared with that of a comparable item, warranty considerations, maintenance availability, environmental and energy efficiency considerations, delivery terms, and past performance. In addition to a price quote, the Offeror must submit descriptive literature of the product proposed, a commercial price list, warranty provisions, and any other information the Offeror considers relevant to the Government's evaluation of the product proposed. The Government intends to evaluate the quotes and award the purchase order without discussion with Offerors. Therefore, the initial offer should contain the Offerors best terms for a technical and price standpoint. However, the Government reserves the right to conduct discussions, request product samples or demonstrations, if later determined by the Contracting Officer to be necessary. The Government may reject any and all offers if such action is deemed necessary. The Government may also waive informalities and minor irregularities in the offers received. NOTE: The Offeror must be registered in the Government's Central Contractor Registry (CCR) System, which is available at www.ccr.gov, in order to receive an award from the NIH, NHLBI. FAR provisions and clauses that apply to this acquisition are: FAR 52.212-1, Instructions to Offerors-Commercial Items (JUN 2008); FAR 52.212-2 Evaluation - Commercial Items (JAN 1999); FAR 52.212-3, Offeror Representations and Certifications - Commercial Items (AUG 2011); FAR 212-4 Contract Terms and Conditions - Commercial Items (JUN 2010); FAR 52-212-5, Contract Terms and Conditions Required to Implement Statues or Executive Orders - Commercial Items (AUG 2011) is included with the following additional clauses: FAR 52.232-33, Payment by Electronic Funds Transfer - Central Contractor Registration (OCT2003); and FAR 52.204-7, Central Contractor Registration (APR2008). The clauses are available in full text at http://www.arnet.gov/far. Quotations will be due seven (07) calendar days from the publication date of this synopsis or by August 29, 2011 9:00am, Eastern Standard Time. The quotation must reference Solicitation Number NHLBI-CSB-(AR)-2011-326-CRS. All responsible sources may submit a quotation/proposal, which if timely received, shall be considered by the agency. Interested vendors capable of furnishing the government with the item specified in this synopsis should submit their quotation to the below address. National Heart, Lung, and Blood Institute, 6701 Rockledge Blvd., Room Suite 6150B, Bethesda, Maryland 20892, Attention: Caitlin Savina. Emails will be accepted at savinacr@nhlbi.nih.gov.
- Web Link
-
FBO.gov Permalink
(https://www.fbo.gov/spg/HHS/NIH/NHLBI/NHLBI-CSB-(AR)-2011-326-CRS/listing.html)
- Place of Performance
- Address: NIH, Bethesda, Maryland, 20892, United States
- Zip Code: 20892
- Record
- SN02544152-W 20110824/110822235323-aae27a1d52cf104ab51512148d02e88e (fbodaily.com)
- Source
-
FedBizOpps Link to This Notice
(may not be valid after Archive Date)
| FSG Index | This Issue's Index | Today's FBO Daily Index Page |