SOLICITATION NOTICE
R -- Information Sampling in Impulsive Patients with Parkinson's Disease using fMRI Scans
- Notice Date
- 6/1/2012
- Notice Type
- Presolicitation
- NAICS
- 541990
— All Other Professional, Scientific, and Technical Services
- Contracting Office
- Department of Health and Human Services, National Institutes of Health, National Institute on Drug Abuse, Station Support/Simplified Acquisitions, 31 Center Drive, Room 1B59, Bethesda, Maryland, 20892
- ZIP Code
- 20892
- Solicitation Number
- 2488010
- Archive Date
- 6/23/2012
- Point of Contact
- Hunter A. Tjugum, Phone: 3014358780, Susan Nsangou, Phone: 3014432104
- E-Mail Address
-
hunter.tjugum@nih.gov, nsangous@mail.nih.gov
(hunter.tjugum@nih.gov, nsangous@mail.nih.gov)
- Small Business Set-Aside
- N/A
- Description
- This is a notice of intent, not a request for a proposal. A solicitation document will not be issued and proposals will not be requested. National Institute on Drug Abuse (NIDA), Office of Acquisitions - Neurosciences, Station Support/Simplified Acquisitions, on behalf of the National Institute on Mental Health (NIMH) intends to negotiate and award a purchase order on a noncompetitive basis to the University of Michigan, School of Kinesiology, Office of the Dean, located at 1402 Washington Heights, Ann Arbor, MI 48109, for cost involved in the recruitment of patients with Parkinson's Disease (PD) and Impulsive Control Behavior disorder (ICB). These research patients will undergo Functional MRI scans via infrastructure possessed by the University of Michigan. The study will be conducted to examine the neural circuitry in patients with Parkinson's disease who have an Impulse Control Behavior (ICB) disorder, compared to those PD patients without ICB. It is estimated that only about 15% of people with Parkinson's disease actually exhibit ICB disorder. The population of people with Parkinson's disease and ICB disorder is very uncommon, and is difficult to access. There are also very few institutions that are equipped with the infrastructure needed to implement Functional MRI scans on patients with Parkinson's disease. The School of Kinesiology at the University of Michigan possesses both of these traits however, providing a unique opportunity, incomparable to anything else presently in the field. The Functional MRI scans in the NIMH research will be implemented on a 3T General Electric Signa scanner (GE Medical Systems) and 8-channel head coil (or equivalent). Collection will comprise whole-brain T2*-weighted echoplaner imaging volumes with 35 slices, 3.5 mm thick, matrix: 64 x 64, in -plane resolution 3.75 mm, TR 2 s, TE 30 ms, flip angle 90 deg. All research participants will undergo six scanning sessions. The first five sessions will be "dummy scans" and discarded to allow for magnetization equilibration effects. The School of Kinesiology at the University of Michigan is the only known responsible source able to provide these services; no other known source can satisfy agency requirements; FAR Subpart 6.302-1. Data collection for this study consists of using research protocols at the University of Michigan. Participants will be measured on the "Unified Parkinson's Disease Rating Scale" (UPDRS) after they undergo scanning on the fMRI. Before the scanning session, participants will fill out the Barrett Impulsivity Questionnaire and a reward discounting questionnaire. Data collection authority is contingent on a current review process underway at the NIH. This is a study of mechanism, and is not meant to test any new therapy. It is only meant to provide insight into the circuits which might mediate ICB disorder. This study is not designed to be a clinical trial. A Clinical Exemption request is currently in review by the NIH, per the Paperwork Reduction Act (PRA). If this study is determined to be clinically exempt, the PRA does not apply. If not clinically exempt however, this NIMH study will have to go through the PRA clearance process, which can take up to six months. Data collection will then be delayed until the PRA clearance process is complete. This acquisition is being conducted under Simplified Acquisition Procedures using FAR 12 procedures. The determination by the Government not to compete the proposed contract based upon responses to this notice is solely within the discretion of the Government. Comments to this announcement, referencing NOI2488010, may be submitted prior to the closing date of this announcement to the NIDA SS/SA Branch electronically to the attention of Hunter A. Tjugum at hunter.tjugum@nih.gov.
- Web Link
-
FBO.gov Permalink
(https://www.fbo.gov/spg/HHS/NIH/NIDA-2/2488010/listing.html)
- Place of Performance
- Address: Bethesda, Maryland, 20814, United States
- Zip Code: 20814
- Zip Code: 20814
- Record
- SN02764508-W 20120603/120602000301-dd980de52aa5422ee96d96ddf3791103 (fbodaily.com)
- Source
-
FedBizOpps Link to This Notice
(may not be valid after Archive Date)
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