SOLICITATION NOTICE
R -- Data transfer and analysis of RNA sequencing data of all genes (exons, not introns) in the NCI-60 plus BR:MDA MB-468 cell lines
- Notice Date
- 6/21/2012
- Notice Type
- Presolicitation
- NAICS
- 541990
— All Other Professional, Scientific, and Technical Services
- Contracting Office
- Department of Health and Human Services, National Institutes of Health, National Cancer Institute, Office of Acquisitions, 6120 Executive Blvd., EPS Suite 600, Rockville, Maryland, 20852
- ZIP Code
- 20852
- Solicitation Number
- NCI-120057a-TG
- Archive Date
- 7/20/2012
- Point of Contact
- Terry Galloway, Phone: 301-402-4509, Caren N Rasmussen, Phone: (301) 402-4509
- E-Mail Address
-
gallowaytl@mail.nih.gov, cr214i@nih.gov
(gallowaytl@mail.nih.gov, cr214i@nih.gov)
- Small Business Set-Aside
- Total Small Business
- Description
- Contracting Office Address Department of Health and Human Services, National Institutes of Health, National Cancer Institute, Office of Acquisitions, 6120 Executive Blvd. EPS Room 6074, Rockville, MD, 20852, UNITED STATES Description The National Cancer Institute (NCI), Center for Cancer Research (CCR), Laboratory of Molecular Pharmacology (LMP), Genomics & Bioinformatics Group (GBG) plans to procure Data transfer and analysis of RNA sequencing data of all genes (exons, not introns) in the NCI-60 plus BR:MDA MB-468 cell lines. This acquisition will be processed in accordance with simplified acquisition procedures as stated in FAR Part 13.106-1(b)(1). The North American Industry Classification System code is 541990 and the business size standard is $7.0 million. Only one award will be made as a result of this solicitation. This will be awarded as a firm fixed price type contract. This requirement is set-aside for small business. Period of Performance shall be from award through twelve (12) months. It has been determined there are no opportunities to acquire green products or services for this procurement. The LMP's mission is to manage and assess molecular interaction data obtained through multiple platforms, increase the understanding of the effect of those interactions on the chemosensitivity of cancer, and create tools that will facilitate that process. Translation of that information and data will be directed towards the recognition of diagnostic and therapeutic cancer biomarkers, and directed cancer therapy. The contractor shall perform the following tasks. Task A. Downloading and uploading of data. Task B. RNA sequencing variant synopsis and comparisons providing detailed tables for i) the total number of variants present, ii) presences or absence in the 1000 genomes project, iii) presence or absences in the COSMIC database, iv) SIFT Score, v) POLYPHEN-2 score, vi) chromosomal location, vii) type of variant (missense, frameshift, nonsense, etc.), viii) Pfam domain, and ix) Transcript level. Task C. RNA sequencing transcript analysis. The contractor shall i) determine transcript expression levels, including the fragments per kilobase per million reads (FPKM) and confidence intervals; ii) identify gene fusions and translocations, including the location of the two fused or translocated segments; and iii) do alternative splicing analysis to align sequenced transcripts to known reference sequences, iv) identify novel variants and determine levels of known and novel splice variants. Task D. Provide reports detailing the approachs used and results of these analyses Potential offerors may request a copy of the solicitation from Terry Galloway, Contract Specialist via electronic mail at gallowaytl@mail.nih.gov or fax (301) 402-4513. Interested parties shall include the name of company; complete mailing address; point of contacts, phone, fax numbers, and email address; company DUNS number and business size. All questions shall be in writing and may be addressed to the aforementioned individual noted above. No collect calls will be accepted. In order to receive an award, contractors must be registered and have valid certification in the Central Contractor Registration (CCR) and the Online Representations and Certifications Applications (ORCA). Reference: RFQ-NCI-120057-TG on all correspondence.
- Web Link
-
FBO.gov Permalink
(https://www.fbo.gov/spg/HHS/NIH/RCB/NCI-120057a-TG/listing.html)
- Record
- SN02783141-W 20120623/120622000346-c073aebdd7d2ce3cbd8ac1bcd5559a67 (fbodaily.com)
- Source
-
FedBizOpps Link to This Notice
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