Loren Data's SAM Daily™

FBO DAILY ISSUE OF AUGUST 24, 2012 FBO #3926
SOLICITATION NOTICE

R -- Biochemical and Biophysical Services

Notice Date

8/22/2012
 

Notice Type

Combined Synopsis/Solicitation
 

NAICS

541712 — Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology)
 

Contracting Office

Department of Health and Human Services, National Institutes of Health, National Heart, Lung and Blood Institute, Rockledge Dr. Bethesda, MD, Office of Acquisitions, 6701 Rockledge Dr RKL2/6100 MSC 7902, Bethesda, Maryland, 20892-7902
 

ZIP Code

20892-7902
 

Solicitation Number

NHLBI-CSB-(AR)-2012-268-CSP
 

Archive Date

9/13/2012
 

Point of Contact

Caitlin Palmer,
 

E-Mail Address

caitlin.palmer@nhlbi.nih.gov
(caitlin.palmer@nhlbi.nih.gov)
 

Small Business Set-Aside

Total Small Business
 

Description

COMBINED SYNOPSIS / SOLICITATION (1)Action Code Combined Synopsis/Solicitation (2)Date: August 22, 2012 (3)Year: Fiscal Year 2012 (4)Contracting Office ZIP Code: 20892 (5)Classification Code: R (6)Contracting Office Address:.....National Institutes of Health, National Heart, Lung and Blood Institute, 6701 Rockledge Boulevard, Suite 6147B, Bethesda, Maryland 20892-7902 (7)Subject:.....Biochemical and Biophysical Services for the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) (8)Proposed Solicitation Number: NHLBI-CSB-(AR)-2012-268-CSP (9)Closing Response Date: August 29, 2012 (10)Contracting Officer: Robin Jeffries, Contracting Officer (11)Contract Award and Solicitation Number: Not Applicable (12)Contract Award Dollar Amount: Not Applicable (13)Contract Line Item Number: Not Applicable (14)Contract Award Date: Not Applicable (15)Contractor: Not Applicable (16)Description (i) This is a combined synopsis/solicitation for commercial items prepared in accordance with the format in FAR 12.6, as supplemented with additional information included in this notice. This announcement constitutes the only solicitation; proposals are being requested and a written solicitation will not be issued. (ii) The solicitation number is NHLBI-CSB-(AR)-2012-268-CSP and the solicitation is issued as a request for quotation (RFQ). (iii) This combined synopsis / solicitation document and incorporated provisions and clauses are those in effect through Federal Acquisition Circular 2005-60, July 26, 2012. (iv) The North American Industry Classification (NAICS) Code is 541712 and the business size standard is 500 employees. THIS REQUIREMENT IS 100% SET ASIDE FOR SMALL BUSINESS. This acquisition is being conducted using Simplified Acquisition Procedures in accordance with FAR Part 13. (v) Offerors must submit all questions concerning this solicitation in writing to caitlin.palmer@nih.gov. All questions must be received by 5:00 p.m. EST August 24, 2012. All responses to questions will be made in writing, without identification of the questioner, and will be included in an amendment to the solicitation on or before, August 27, 2012. (vi) Background The National Institutes of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), Intramural Research Program (IRP), Laboratory of Structural Biology Research (LSBR) seeks to elucidate structure-function-assembly relationships of macromolecular complexes by cryo-electron microscopy integrated with other approaches. Systems currently under study include viruses, cytoskeletal filaments, energy-dependent proteases, and amyloid filaments. The LSBR is committed to a comprehensive program of innovative scientific research into the structure and assembly of macromolecular complexes including, in particular, viral capsids. These viral capsids require specialized assistance from the requested contractor; in the preparation, manipulation, and analysis of capsids by electron microscopy, and other biophysical techniques. Purpose and Objectives The LSBR requires the services of a Contractor with demonstrated experience and skills in handling and analyzing capsids of the herpes simplex virus, related proteins and protein complexes. The Contractor will isolate precursor capsids and break down complete mature virions to study their protein compositions and the interactions among these proteins. Major experimental objectives are as follows: -Prepare fresh and structurally homogeneous preparations of the procapsid of herpes simplex virus. -Prepare virions intended for structural studies of the herpes virus tegument by electron tomography. -Prepare virions depleted of their envelopes and designated tegument components, as well as such particles to which other proteins have been specifically bound. -Isolate the 336-kDa viral protein UL36, and study its structure by EM. -Isolate complexes ofUL36 with other viral proteins -UL37, UL 17 and UL25. Map their binding sites. -Advise and assist with crystallization project(s) of the triplex complexes of herpes simplex and other herpes viruses. Contractor Requirements The Contractor shall: • Be primarily involved in generating preparations of purified viral particles and subviral particles- and viral proteins for structural analysis, and may also participate in said structural analysis. To do so, the Contractor must have demonstrated knowledge and experience in propagating viruses under tissue culture conditions, and in isolating targeted molecules from the infected cells. • Have adequate experience in operating needed equipment, such as freezers, refrigerators, centrifuges, incubators, tissue culture equipment, power supplies, gel and immunoblotting equipment, water baths, pH meters, balances, electron microscopes, spectrophotometers, and equipment for chromatography. • Appropriately document his/her experimental work and will participate in the LSBR's program of "Data Club" seminars. (vii) Period and Place of Performance The period of performance is eight (8) months. The Contractor will work on the NIH campus, using government-provided office space, laboratory bench-space, and access to such equipment, and other resources as are available in the LSBR. Free parking on the NIH campus is provided; however, mileage is not provided. Level of Effort The Contractor's position is part-time (20 hours per week) for the first 4 months, and full-time (40 hours per week) for the second 4 months- for 1,020 hours. Exclusive of all federal holidays. No overtime shall be paid. (viii) FAR clause 52.212-1, Instructions to Offerors - Commercial Items is applicable to this requirement. The Offer shall include all documents as cited in the clause. An addendum is not applicable to this provision. (ix) EVALUATION OF QUOTES: The Government intends to award a single contract from this solicitation. The Government reserves the right not to award a contract. Evaluation of Proposals: The Government reserves the right to make an award without discussions based solely upon initial proposals. The Government will use a tradeoff process for this source selection. Award will be made to the responsible offeror whose offer conforms to the solicitation requirements and provides the best value to the Government, non-price factors and price considered. Relative importance: 1. All evaluation factors other than Price, when combined, are more important than price. 2. As the Non-Price technical rating becomes more equal between offerors, price becomes more important. TECHNICAL EVALUATION FACTORS: TECHNICAL EVALUATION FACTOR #1: Demonstrated expertise, as evidenced by peer reviewed scientific publications, in the propagation of herpes viruses, their isolation by biochemical and biophysical techniques, and in the purification and analysis of related proteins and protein complexes. Total Possible Points: 25 TECHNICAL EVALUATION FACTOR #2: Experience in the use of electron microscopes, and expertise with various electron microscopy sample preparation techniques, including negative stain and thin sections. Total Possible Points: 25 TECHNICAL EVALUATION FACTOR #3: Experience working on and contributing to imaging projects by electron microscopy, computational image processing, and x-ray crystallography. Total Possible Points: 25 TECHNICAL EVALUATION FACTOR #4: Experience in operating necessary equipment, such as tissue culture equipment, equipment for chromatography, centrifuges, incubators, gel and immunoblotting equipment, power supplies, spectrophotometers, water baths, pH meters, balances, freezers and refrigerators. Total Possible Points: 25 PAST PERFORMANCE: The offeror's past performance information will be evaluated subsequent to the technical evaluation. However, this evaluation will not be conducted on any offeror whose proposal is determined to be technically unacceptable. The evaluation will be based on information obtained from references provided by the offeror, other relevant past performance information obtained from other sources known to the Government, and any information supplied by the offeror concerning problems encountered on the identified contracts and corrective action taken. The government will assess the relative risks associated with each offeror. Performance risks are those associated with an offeror's likelihood of success in performing the acquisition requirements as indicated by that offeror's record of past performance. The assessment of performance risk is not intended to be a product of a mechanical or mathematical analysis of an offeror's performance on a list of contracts but rather the product of subjective judgment by the Government after it considers relevant information. When assessing performance risks, the Government will focus on the past performance of the offeror as it relates to all acquisition requirements, such as the offeror's record of performing according to specifications, including standards of good workmanship; the offeror's record of controlling and forecasting costs; the offeror's adherence to contract schedules, including the administrative aspects of performance; the offeror's reputation for reasonable and cooperative behavior and commitment to customer satisfaction; and generally, the offeror's business-like concern for the interest of the customer. The Government will consider the currency and relevance of the information, source of the information, context of the data, and general trends in the offeror's performance. The lack of a relevant performance record may result in an unknown performance risk assessment, which will neither be used to the advantage nor disadvantage of the offeror. PRICE: An evaluation of the offeror's price proposal will be made to determine if proposed prices are realistic for the work to be performed, reflect a clear understanding of the requirements, and are consistent with the technical proposal. Reasonableness determinations will be made by determining if competition exists, by comparing proposed prices with established commercial and/or by comparing proposed prices with the Independent Government Cost Estimate (IGCE). (x) The Offeror must submit a completed copy of the provision at FAR clause 52.212-3, Offeror Representations and Certifications - Commercial Items, with its offer. (xi) FAR clause at 52.212-4, Contract Terms and Conditions - Commercial Items, applies to this acquisition. The following clauses are added as and addendum to FAR clause 52.212-4 and are applicable to this requirement: FAR Clause 52.209-7 Information Regarding Responsibility Matters (Jan 2011); FAR Clause 52.216-2, Economic Price Adjustment--Standard Supplies (January 1997); FAR Clause 52.216-19, Order Limitations (October 1995); and FAR Clause 52.217-6, Option for Increased Quantity (March 1989). (xii) FAR clause at 52.212-5, Contract Terms and Conditions Required to Implement Statutes or Executive Orders - Commercial Items, applies to this acquisition. The following are the additional FAR clauses cited in the clause applicable to this acquisition: (1) 52.222-50, Combating Trafficking in Persons (FEB 2009) (22 U.S.C. 7104(g)); Alternate I (AUG 2007) of 52.222-50 (22 U.S.C. 7104(g)); 52.233-3, Protest after Award (AUG 1996) (31 U.S.C. 3553); 52.233-4, Applicable Law for Breach of Contract Claim (OCT 2004) (Pub. L. 108-77, 108-78); 52.219-6, Notice of Total Small Business Set-Aside (JUNE 2003) (15 U.S.C. 644).; Alternate I (OCT 1995) of 52.219-6; 52.222-19, Child Labor--Cooperation with Authorities and Remedies (JUL 2010) (E.O. 13126); 52.222-21, Prohibition of Segregated Facilities (FEB 1999); and 52.222-35, Equal Opportunity for Veterans (SEP 2010) (38 U.S.C. 4212). (xiii) Other Important Considerations N/A (xiv) The Defense Priorities and Allocations System (DPAS) is not applicable to this requirement. (xv) All offerors shall submit two electronic files to caitlin.palmer@nih.gov. One electronic file shall contain all technical information; the second electronic file shall contain all pricing information. All quotes shall contain the following: 1) Offerors must complete annual representations and certifications on-line at https://www.sam.gov/portal/public/SAM/. If paragraph (j) of the provision applies, a written submission is required. (refer to item (x) above). 2) Provide the name of the biologist and proof of bachelor's degree in biomedical engineering, biology, or a related area. 3) TECHNICAL EVALUATION FACTOR #1: Offerors shall submit at least (2) two descriptions of projects, in the past two (2) years, demonstrating the biologist's experience as evidenced by peer reviewed scientific publications, in the propagation of herpes viruses, their isolation by biochemical and biophysical techniques, and in the purification and analysis of related proteins and protein complexes. (include description; dollar value; period of performance; contact name and phone number). 4) TECHNICAL EVALUATION FACTOR #2: Offerors shall submit at least (2) two descriptions of projects, in the past two (2) years, demonstrating the biologist's experience in the use of electron microscopes, and expertise with various electron microscopy sample preparation techniques, including negative stain and thin sections. (include description; dollar value; period of performance; contact name and phone number). 5) TECHNICAL EVALUATION FACTOR #3: Offerors shall submit at least (2) two descriptions of projects, in the past two (2) years, demonstrating the biologist's experience working on and contributing to imaging projects by electron microscopy, computational image processing, and x-ray crystallography. (include description; dollar value; period of performance; contact name and phone number). 6) TECHNICAL EVALUATION FACTOR #4: Offerors shall submit at least (2) two descriptions of projects, in the past two (2) years, demonstrating the biologist's experience in operating necessary equipment, such as tissue culture equipment, equipment for chromatography, centrifuges, incubators, gel and immunoblotting equipment, power supplies, spectrophotometers, water baths, pH meters, balances, freezers and refrigerators. (include description; dollar value; period of performance; contact name and phone number) NOTE: For Technical Evaluation Factor's #1, #2, #3, and #4, if the contractor has a project that encompasses two or more of the three evaluation factors one project can be submitted. Meaning, individual projects for each factor would not need to be submitted for each factor, if a project addresses multiple factors. However, please identify in the project's description which factor's the project addresses. PAST PERFORMANCE: The Offeror shall provide three (3) purchase orders/contracts (Federal Government, State Agencies, Local Government; and commercial concerns), similar to this requirement. Include the following information for each contract or subcontract listed: 1. Name of Contracting Organization 2. Contract Number (for subcontracts, provide the prime contract number and the subcontract number) 3. Contract Type 4. Total Contract Value 5. Description of Requirement 6. Contracting Officer's Name and Telephone Number 7. Program Manager's Name and Telephone Number 8. North American Industry Classification System (NAICS) Code The offeror may provide information on problems encountered on the identified contracts and the offeror's corrective actions. The Government is not required to contact all references provided by the offeror. Also, references other than those identified by the offeror may be contacted by the Government to obtain additional information that will be used in the evaluation of the offeror's past performance. 7) PRICE: Provide a firm-fixed hourly rate for the services described in the Statement of Work. 8) If applicable, the offeror shall list exception(s) and rationale for the exception(s). 9) In order to receive an award from NHLBI, contractors must have a valid registration in the System for Award Management (SAM) located at https://www.sam.gov/portal/public/SAM/ Offerors shall submit their proposals no later than 1:00 p.m. Eastern Standard Time (EST) on August 29, 2012. The proposal must reference the RFP No. NHLBI-CSB-(AR)-2012-268-CSP. All responsible offerors may submit a proposal, which if timely received, shall be considered by the agency. Proposals can be emailed to the Contract Specialist, Caitlin Palmer at caitlin.palmer@nih.gov; Quotations shall not be deemed received by the Government until the quotation is entered into the e-mail address inbox set forth above. (xvi) For Additional information, contact Caitlin Palmer, Contract Specialist, electronically at caitlin.palmer@nih.gov. (10) Place of Contract Performance: Bethesda, Maryland 20892 (11) Set-aside Status: 100% Total Small Business Set Aside.
 

Web Link

FBO.gov Permalink
(https://www.fbo.gov/spg/HHS/NIH/NHLBI/NHLBI-CSB-(AR)-2012-268-CSP/listing.html)
 

Place of Performance

Address: NIH, Bethesda, Maryland, 20892, United States

Zip Code: 20892
 

Record

SN02850659-W 20120824/120823001025-6e6f705dcab0d0520c086ecfbd2e5b43 (fbodaily.com)
 

Source

FedBizOpps Link to This Notice
(may not be valid after Archive Date)

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