SOLICITATION NOTICE
R -- Radiopharmaceutical production of amyloid imaging radioisotopes
- Notice Date
- 12/5/2012
- Notice Type
- Presolicitation
- NAICS
- 541990
— All Other Professional, Scientific, and Technical Services
- Contracting Office
- Department of Health and Human Services, National Institutes of Health, National Institute on Drug Abuse, Station Support/Simplified Acquisitions, 31 Center Drive, Room 1B59, Bethesda, Maryland, 20892
- ZIP Code
- 20892
- Solicitation Number
- NOI2793266
- Archive Date
- 12/27/2012
- Point of Contact
- Hunter A. Tjugum, Phone: 301 435 8780
- E-Mail Address
-
hunter.tjugum@nih.gov
(hunter.tjugum@nih.gov)
- Small Business Set-Aside
- N/A
- Description
- This is a notice of intent, not a request for a proposal. A solicitation document will not be issued and proposals will not be requested. The National Institute on Drug Abuse (NIDA), Office of Acquisitions - Neurosciences, Station Support/Simplified Acquisitions on behalf of the National Institute of Aging (NIA) intends to negotiate a Purchase Order on a sole source basis with the Johns Hopkins University located at 600 North Wolfe Street, Baltimore, MD 21205. Purchase Order will include identifying structural and functional brain changes as early indicators of cognitive decline and Alzheimer's disease in participants involved in the Baltimore Longitudinal Study of Aging (BLSA). The Laboratory of Genetics at the NIA has a need to perform and quantify in vivo brain scans of amyloid neuropathology and regional cerebral blood flow (rCBF) using Positron Emission Tomography (PET). Changes in amyloid deposition will be measured using PET and C-Pittsburgh Compound-B (PiB). PET scans will also be used to measure rCBF with O-water to allow comparison with previously measured levels of rCBF in BLSA participants. Measurement of rCBF uses 15-water, which has a 2-minute half-life, and C-PiB that has a 20-minute half-life. These measurements include radioisotopes that require an on-site cyclotron for radiopharmaceutical production. Contractor shall acquire the PET O-water and C-PiB neuroimaging scans and provide quantitative analysis of imaging data using kinetic modeling techniques. Information on changes in rCBF and amyloid deposition in vivo will be combined with the existing physical and psychological data for BLSA participants and provide insight on preclinical biomarkers of cognitive impairment including Alzheimer's disease. Scientific aims include investigating changes in brain function and amyloid burden as early biomarkers of cognitive decline and impairment including Alzheimer's disease; and to identify protective factors that may prevent or delay the onset of cognitive impairment in normal individuals that have substantial amyloid burden. In order to identify structural and functional brain changes of cerebral blood flow and amyloid deposition in BLSA participants, evaluations need to be performed using cyclotron produced short-lived radioactive isotopes. This neuroimaging requires an on-site cyclotron given the time constraints of the radioactive material for radiopharmaceutical production. Johns Hopkins Medical Institution is the only facility in the Baltimore region that possesses the necessary PET equipment and is capable of producing the radiopharmaceuticals within the time limits of this study. The period of performance is 12 months, with the option to add four (4) additional one-year optional periods of performance. This acquisition is being conducted under FAR Part 12, in conjunction with the policies and procedures for solicitation, evaluation, and award prescribed in Part 13, Simplified Acquisition Procedures, and is exempt from the competition requirements of Part 6. This notice of intent is not a request for competitive proposals. Interested parties may identify their interest and capabilities in response to this synopsis. The determination by the Government not to compete the proposed contract based upon responses to this notice is solely within the discretion of the Government. Comments to this announcement, referencing this synopsis number, may be submitted to the NIDA SS/SA Branch, prior to the closing date specified in this announcement, electronically to the attention of Hunter A. Tjugum, at tjugumha@mail.nih.gov.
- Web Link
-
FBO.gov Permalink
(https://www.fbo.gov/spg/HHS/NIH/NIDA-2/NOI2793266/listing.html)
- Record
- SN02942826-W 20121207/121205234055-00d10cd1d09d17afb471f112c9476bdc (fbodaily.com)
- Source
-
FedBizOpps Link to This Notice
(may not be valid after Archive Date)
| FSG Index | This Issue's Index | Today's FBO Daily Index Page |