SOURCES SOUGHT
66 -- Flow Field flow Fractionation (FFF) Instrument
- Notice Date
- 4/18/2013
- Notice Type
- Sources Sought
- NAICS
- 334516
— Analytical Laboratory Instrument Manufacturing
- Contracting Office
- Department of Commerce, National Institute of Standards and Technology (NIST), Acquisition Management Division, 100 Bureau Drive, Building 301, Room B129, Mail Stop 1640, Gaithersburg, Maryland, 20899-1640, United States
- ZIP Code
- 20899-1640
- Solicitation Number
- AMD-AGP-13-02497
- Archive Date
- 5/17/2013
- Point of Contact
- Andrea A Parekh, Phone: (301)975-6984
- E-Mail Address
-
andrea.parekh@nist.gov
(andrea.parekh@nist.gov)
- Small Business Set-Aside
- N/A
- Description
- This is a SOURCES SOUGHT NOTICE for market research purposes. THIS IS NOT A REQUEST FOR QUOTATIONS The Material Measurement Laboratory's Bioprocess Measurements Group has a project that develops stable, long-lived standards and reference materials that mimic and approximate the physicochemical and optical properties of proteins and protein particles used in protein-based drugs. In order to characterize more fully these candidate materials, analytical instrumentation is need that facilitates the following: 1. Size-based separation of nanoscale materials 2. Online measurement of radius of gyration 3. Online measurement of translational diffusion coefficient 4. Online measurement of ultraviolet/visible (UV/Vis) absorbance spectra 5. Online measurement of refractive index 6. Calculation of particle number concentration at each particle size 7. Measurement of sample zeta potential A suitable technology to accomplish these measurement requirements is field flow fractionation (for size-based separation) coupled online with multi-angle light scattering, dynamic light scattering, electrophoretic light scattering, UV/Vis spectrophotometer and differential refractive index detectors in buffers of physiologically relevant ionic strength. The proposed acquisition is for procurement of a flow field flow fractionation (FFF) instrument coupled online with multi-angle light scattering, dynamic light scattering, UV/Vis spectrophotometer, differential refractive index and absolute refractive index detectors. The Contractor shall provide one (1) FFF instrument coupled online with multi-angle light scattering, dynamic light scattering, UV/Vis spectrophotometer, differential refractive index and absolute refractive index detectors that meet the following minimum technical requirements. The hardware shall consist of an automated, computer-controlled flow field fractionation separation systems complete with necessary fluidic degassing, filtration and flow control systems. 1.0 Hardware 1. Online multi-angle light scattering, 2. Online dynamic light scattering, 3. Online UV/Vis spectrophotometer, 4. Online refractive index detector. 5. Zeta potential/electrophoretic light scattering detector Multi-angle light scattering detector: • Laser light source shall be linearly polarized and have an output power of 120 mW or higher. • Detector shall be able to measure light scattering intensity at 18 or more angles simultaneously. • Detectors shall be able to measure the molar mass of standard protein samples, e.g. bovine serum albumin within +/- 5% of accepted literature values and the radius of gyration of poly(styrene) nanoparticle standards within +/- 5% of manufacturer specified values. Dynamic light scattering detector: • Detector shall be able to interface with multi-angle light scattering detector (defined above) to measure dynamic light scattering signal at any of the angles specified above. • Must incorporate a multi-tau correlator that does not scale scattered light intensities, to allow correlation of low-level intensity fluctuations facilitating the detection of small amounts of particles over a wide range of particle sizes without any user adjustments. • ic radius of bovine serum albumin with +/- 10% of accepted literature values. UV/Vis spectrophotometer: • Spectrophotometer shall be able to acquire and store UV/Vis spectra over the wavelength range of ~190 nm to ~800 nm. Differential refractive index detector: • The refractive index detector shall have a sufficient plurality of discrete photodiode detectors to cover 9 decades of dynamic range in a single set of gain settings. 2.0 Software • The purchase shall include software for data acquisition of automated control of FFF instrument suite (including ancillary detectors described above). The Contractor shall install the FFF instrument suite. The Contractor shall also provide training at the installation site for up to three users. The Contractor shall warrants that the flow field fractionation tandem light scattering instrument suite system shall correspond with its specification at the time of delivery and shall be free from defects in material and workmanship for a period of 12 months (or longer) from the date of acceptance by the Government. Delivery shall occur not later than 60 days after receipt of the order. NIST is seeking responses from all responsible sources, including large, foreign, and small businesses. Small businesses are defined under the associated NAICS code for this effort, 334516 (Analytical Laboratory Instrument Manufacturing), with a size standard of 500 employees or less. Please include your company's size classification in any response to this notice. If two or more small businesses are identified, we will consider a set-aside. Companies that can manufacture, install and train NIST personnel on the above instrument system are requested to email their technical capability statement in a letter to Andrea.Parekh@nist.gov no later than the response date for this sources sought notice. The letter shall include any information relevant to your capabilities. Also, the following information is requested as part of the response to this sources sought notice: 1. Name and size of the company. 2. Detailed narrative on same or similar instrument systems that are to be installed or are in use in laboratory facilities. 3. Product literature 4. Indication of whether the services required are currently on one or more GSA Federal Supply Schedule contracts and, if so, the GSA FSS contract number(s). 5. Any other relevant information that is not listed above which the government should consider in finalizing its market research. All documents must be sent to Andrea Parekh, Contract Specialist, at the National Institute of Standards and Technology, Acquisition Management Division, 100 Bureau Drive, Mail Stop 1640, Gaithersburg, MD 20899-1640. Email address: Andrea.Parekh@nist.gov. Submission must be received not later than May 02, 2013.
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