SOURCES SOUGHT
R -- Research Data Review and Publication Support for NIDA IRP
- Notice Date
- 1/30/2015
- Notice Type
- Sources Sought
- NAICS
- 541690
— Other Scientific and Technical Consulting Services
- Contracting Office
- Department of Health and Human Services, National Institutes of Health, National Institute on Drug Abuse, Station Support/Simplified Acquisitions, 31 Center Drive, Room 1B59, Bethesda, Maryland, 20892
- ZIP Code
- 20892
- Solicitation Number
- HHS-NIH-NIDA-SSSA-SBSS-15-108
- Archive Date
- 2/24/2015
- Point of Contact
- Lauren M. Phelps, Phone: 3015942490
- E-Mail Address
-
lauren.phelps@nih.gov
(lauren.phelps@nih.gov)
- Small Business Set-Aside
- N/A
- Description
- Contracting Office Address: Department of Health and Human Services, National Institutes of Health, National Institute on Drug Abuse, Station Support Simplified Acquisitions, 31 Center Drive, Room 1B59, Bethesda, MD 20892, UNITED STATES. Introduction: This is a Small Business Sources Sought notice. This is NOT a solicitation for proposals, proposal abstracts, or quotations. The purpose of this notice is to obtain information regarding: (1) the availability and capability of qualified small business sources, (2) whether they are small businesses; HUBZone small businesses, service-disabled, veteran-owned small businesses; 8(a) small businesses; veteran-owned small businesses; woman-owned small businesses; or small disadvantaged businesses; and (3) their size classification relative to the North American Industry Classification System (NAICS) code for the proposed acquisition. Your responses to the information requested will assist the Government in determining the appropriate acquisition method, including whether a set-aside is possible. Background: A major research direction of the Drug Design and Synthesis Section (DDSS), in the Molecular Targets and Medications Discovery Branch (MTMDB) of the Intramural Research Program (IRP) of the National Institute on Drug Abuse (NIDA), is the elucidation of the structure and function of neurotransmitter systems in the mammalian central nervous system (CNS) and the molecular mechanism of action of CNS active drugs. Organic/medicinal chemistry is the foundation of the multidisciplinary antagonists, imaging agents, affinity ligands, and other drugs for specific applications. New, highly selective ligands for drug receptors are synthesized, using all of the contemporary tools of medicinal chemistry. DDSS is involved with research on: (1) central opioid receptor subtypes and peripheral opioid receptors, (2) narcotic tolerance and dependence, (3) the synthesis of haptens for a heroin vaccine, and (4) the development of new ligands for positron emission tomography (PET) and single photon emission computed tomography (SPECT) imaging of drug receptors in the CNS of living animals and conscious humans. Potent and selective ligands are prepared for specific opioid receptors. We have provided tools for PET imaging of opioid receptors, purified the delta opioid receptor to homogeneity seven years prior to cloning, introduced corticotropin releasing hormone antagonists for study of stress-induced relapse to drug abuse and developed the NIH Opiate Total Synthesis. The latter renders the natural opiate enantiomers available independent of the opium poppy and thus offers poppy eradication a strategy to combat heroin abuse. It also provides unnatural opiates as valuable research tools and as potential agents for the treatment of drug abuse via functional antagonism of Toll-like 4 receptors. DDSS, MTMDB, is unique in its ability to forge ahead on these difficult and extremely important areas of science. It is essential that the research findings of DDSS, MTMDB, be made available to the scientific community by publication in highly rated journals. Purpose and Objectives for the Procurement: The purpose of this potential requirement is acquisition of contractor support services to ensure that scientific data obtained in the Section is published in refereed journals and interested DDSS postdoctoral scientists are acquainted about the publication process. Support is also required for consultation to assist the DDSS in ensuring that current and future research projects suitable for publication will be carried out. Support will be provided by the contractor to help postdoctoral fellows - the DDSS Visiting Fellows and IRTAs, mostly organic chemists (some of whom do not have English as their primary language), become more familiar with the writing of manuscripts in various scientific journals, and with the background of the research. The contractor will also aid with the presentation of posters and oral reports by postdoctoral fellows, and be available to provide support both onsite and/or through a home office via phone or email as approved by the Government. Project Requirements: The Contractor shall perform the following tasks: 1) Dissemination of DDS Work The contractor will assist the Chief (DDSS, NIDA) to collect, review, and select DDSS research data to publish in first-rate, refereed scientific journals. The number of manuscripts is variable, and is dependent on the number and the output of the postdoctoral fellows. During the past 4 years, the Chief (DDSS, NIDA) has been a co-author on 94 publications. The contractor will also aid with the presentation of posters and oral reports by postdoctoral fellows, and will be available for consultation both onsite and/or through a home office via phone or email. a ) Manuscript Preparation: The contractor shall assist with writing manuscripts for publication and training interested postdoctoral fellows to write. This will include assistance with the introduction, results and discussion, and conclusion, compilation of references and acknowledgement sections of a manuscript, as well as gathering of materials (e.g. CCDC numbers when necessary for publication) for all DDSS manuscripts. The postdoctoral fellows in DDSS will provide written experimental work needed for the manuscript to the contractor. The Contractor will assist with the creation of manuscripts including both text and visual elements using Microsoft Word, ChemDraw, Endnote, etc. The work must be compatible with the Apple operating system for Mac computers. The Contractor will provide support to modify the written experimental work provided by DDSS postdoctoral fellows for compliance with journal requirements, will examine the experimental work to assure that it is complete and sufficient for publication, and will request additional information from scientists when the Contractor or Chief (DDSS, NIDA) deems it necessary. The Contractor will provide support to ensure that all manuscripts are written in accordance with the requirements of the journals in which they shall be published, and proof read all manuscripts for spelling, grammar, and nomenclature. The journals will be chosen by joint agreement of the Chief (DDSS, NIDA), the author (s), the DDSS postdoctoral fellows involved. The Contractor may provide recommendations as requested. Journals for potential publication may include, but are not limited to, the Journal of Medicinal Chemistry, European Journal of Medicinal Chemistry, Journal of Organic Chemistry, Chirality, Bioorganic and Medicinal Chemistry, Organic Letters, Science, Helvetica, Tetrahedron, Organic and Biomolecular Chemistry, Heterocycles, Journal of Heterocyclic Chemistry, Synthesis, Journal of Labelled Compounds and Radiopharmaceuticals, Journal of Natural Products, Tetrahedron Letters. b) Manuscript Submission: a. The Contractor will assist postdoctoral fellows in the preparation of finalized manuscripts for journal submission. Manuscript articles are generally submitted online and submission cover letters drafted for approval by the Chief (DDSS, NIDA). The Contractor will submit manuscripts to journals for the Chief (DDSS, NIDA), and will teach interested postdoctoral fellows how publication is accomplished. b. The Contractor shall make as many unbound copies of the printed manuscript as needed (at this time one copy is needed), prior to submission to the journal and send the copy through the proper channels to the Chief of the Branch, for the Office of the Intramural Scientific Director, for approval. The Contractor shall also provide a copy of each submitted manuscript to each author, either by email or in printed form, as desired by the authors. c. The Contractor will provide support to ensure that all paperwork necessary to establish the manuscript as work of the US Government is completed. Generally this includes the NIH Publishing Agreement which will be filled out and provided to the Chief (DDSS, NIDA) or to the Chief of the Branch for signature, and sent by the Contractor to the journal, generally via an online site, or by whatever other means is deemed necessary. c) Manuscript Revision: Following journal review, the Contractor will assist postdoctoral fellows in the manuscript revision process, and provide answers, if needed, to any comments or questions from journal reviewers and via editorial review. The Contractor may contact the manuscript author(s) as necessary for assistance, and the Contractor will compile the information required for any needed revision. The Contractor will resubmit the revised manuscript, generally using the online site of the journal. Upon resubmission, the Contractor shall assist Government employees to write and include a letter for the Chief (DDSS, NIDA) to the journal editor explaining all revisions made to the manuscript. This entire process will also be used as a teaching tool for interested DDSS postdoctoral fellows who wish to become involved in the process. d) Manuscript Distribution Following manuscript acceptance and publication, the Contractor will ensure that the manuscript is forwarded to PubMed Central for publication in PubMed. The Contractor will be responsible for any manuscript changes needed for PubMed publication and will contact the authors as necessary for this purpose. 2. Poster and Oral Presentation Support a. The Contractor shall assist in examining and proofreading posters from postdoctoral fellows and shall provide recommendations as necessary. b. The Contractor shall assist with oral presentations of postdoctoral fellows and provide recommendations when necessary, especially for DDSS postdoctoral scientists for whom English is not their primary language. 3. Project Communication The Contractor shall be expected to meet with DDSS scientists formally or informally as necessary. A total of 3 or more on-site meetings per week is anticipated. Additionally, the Contractor shall be expected to discuss with the Chief, (DDSS, NIDA), possible current and future research topics that will have the potential for publication. The contractor shall also be expected to discuss with DDSS postdoctoral scientists the background and rationale for their work and assist in preparing them, if needed, to present their work to audiences at national and international scientific conferences and aid in their preparation of seminars/lectures for employment after they leave DDSS, NIDA. Anticipated Period of Performance: The anticipated period of performance is one base year from 05/01/2015 - 04/30/2016 and four (4) option years. Anticipated Level of Effort: The anticipated level of effort is one (1) part-time individual at 20 hours per week. Capability Statement: Contractors that believe they possess the ability to provide the required services should submit documentation of their ability to meet each of the project requirements to the Contract Specialist. The capability statement should include 1) the total number of employees, 2) the professional qualifications of personnel as it relates to the above outlined requirements, 3) an outline of previous scientific research writing activities in which the contractor has participated, and 4) any other information considered relevant to this program. Contractors must also provide their Company Name, DUNS number, Physical Address, and Point of Contact Information. Contractors also should provide a list of IDIQ or GWAC contracts currently maintained that may be of relevance to this potential requirement. Interested organizations are required to identify their type of business, applicable North American Industry Classification System Code, and size standards in accordance with the Small Business Administration. The government requests that no proprietary or confidential business data be submitted in a response to this notice. However, responses that indicate the information therein is proprietary will be properly safeguarded for Government use only. Capability statements must include the name and telephone number of a point of contact having authority and knowledge to discuss responses with Government representatives. Capability statements in response to this market survey that do not provide sufficient information for evaluation will be considered non-responsive. When submitting this information, please reference the solicitation notice number. All capability statements sent in response to this Sources Sought Notice must be submitted electronically (via email) to Lauren Phelps, Contract Specialist, at Lauren.Phelps@nih.gov in MS Word format before the closing date and time of this announcement. All responses must be received by the specified due date and time in order to be considered. Note: This notice does not obligate the Government to award a contract or otherwise pay for the information provided in the response. No proprietary, classified, confidential, or sensitive information should be included in your response. The Government reserves the right to use information provided by respondents for any purpose deemed necessary and legally appropriate. Any organization responding to this notice should ensure that its response is complete and sufficiently detailed to allow the Government to determine the organization's qualifications to perform the work. Respondents are advised that the Government is under no obligation to acknowledge receipt of the information received or provide feedback to respondents with respect to any information submitted. After review of the responses received, pre-solicitation and solicitation notices may be published in Federal Business Opportunities. However, responses to this notice will not be considered adequate responses to a solicitation. The solicitation release date is pending. The Government anticipates negotiation of a firm fixed price contract.
- Web Link
-
FBO.gov Permalink
(https://www.fbo.gov/spg/HHS/NIH/NIDA-2/HHS-NIH-NIDA-SSSA-SBSS-15-108/listing.html)
- Place of Performance
- Address: Rockville, Maryland, 20850, United States
- Zip Code: 20850
- Record
- SN03629615-W 20150201/150130234943-ea98c96fccfaebd3db9e2980f7d7bb85 (fbodaily.com)
- Source
-
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