SOLICITATION NOTICE
66 -- Four year lease of Thermo Scientific™ Q Exactive™ HF hybrid quadrupole-Orbitrap mass spectrometer along with ULTIMATTE 3000 Binary RS nano-LC System
- Notice Date
- 8/27/2015
- Notice Type
- Presolicitation
- NAICS
- 334516
— Analytical Laboratory Instrument Manufacturing
- Contracting Office
- Department of Health and Human Services, National Institutes of Health, National Cancer Institute, Office of Acquisitions, 9609 Medical Center Drive, Room 1E128, Rockville, Maryland, 20852, United States
- ZIP Code
- 20852
- Solicitation Number
- N02RC54103-43
- Archive Date
- 9/23/2015
- Point of Contact
- Andrea Giuliano, Phone: 2402765390, Terry Galloway, Phone: 240-276-5384
- E-Mail Address
-
andrea.giuliano@nih.gov, gallowaytl@mail.nih.gov
(andrea.giuliano@nih.gov, gallowaytl@mail.nih.gov)
- Small Business Set-Aside
- N/A
- Description
- The National Cancer Institute (NCI), Thoracic and GI Oncology Branch, plans to lease on a sole source basis the brand name Thermo Scientific TM Q Exactive TM HF hybrid quadrupole-Orbitrap mass spectrometer along with ULTIMATE 3000 Binary RS nano-LC System from Thermo Electron North Amercia, LLC., 1400 Northpoint Pkwy Ste 50, West Palm Beach, FL, 33407-1976. This acquisition will be processed under FAR Part 12 - Acquisition for Commercial Items and will be made pursuant to the authority in FAR 13.106-1(b)(2) and 13.501-(a)(1) using simplified acquisition procedures for commercial acquisitions. The North American Industry Classification System code is 334516 and the business size standard is 500 employees. Only one award will be made as a result of this solicitation. This will be awarded as a firm fixed price type contract. It has been determined there are no opportunities to acquire green products or services for this procurement. Delivery Date: 60 - 90 days from date of award. Lease Period of Performance: Base plus 3 one year options. The Laboratory of Cell Biology is comprised of 9 sections each working together to unravel the mystery and decipher different aspects of what makes a cell cancerous and how we treat it. Success in treatment of some disseminated cancers with chemotherapy has led to intensified efforts to understand why many other cancers are intrinsically resistant to anticancer drugs or become resistant to chemotherapy after many rounds of treatment. Identifying genes and mechanisms critical to the development of multidrug resistance in vivo and establishing a reliable method for analyzing clinical samples could help to predict the development of resistance and lead to treatments designed to circumvent it. The research of the Thoracic and GI Oncology Branch section focuses on proteomic methodologies to examine targeted treatment of lung cancer. The overall goal is to identify direct or indirect targets of mutant EGFR signaling in lung cancer. This section has undertaken a quantitative mass spectrometry-based approach to solve the problems. This approach helps to identify mechanisms of TKI resistance, biomarkers of TKI response and potential targets for treatment. The Thermo ScientificTM Q ExactiveTM HF hybrid quadrupole-Orbitrap mass spectrometer features an ultra-high-field Orbitrap analyzer which doubles its speed and resolution and allows high throughput sample runs and provides better quantitation results. This section can therefore analyze significantly more samples and cell conditions than before. Thermo Electron North Amercia, LLC will provide the Thermo Scientific TM Q Exactive TM HF hybrid quadrupole-Orbitrap mass spectrometer along with the ULTIMATE 3000 Binary RS nano-LC System. Thermo Electron North America is the sole manufacturer of the Q Exactive HF LC/MS/MS mass spectrometer. It is the only Quadrupole-Orbitrap benchtop mass spectrometer in the world today delivering a maximum resolution of 240,000 (FWHM) at m/z 200 for all scan modes and polarities. This spectrometer features an ultra-high-field Orbitrap analyzer which doubles its speed and resolution and allows high throughput samples run and provides better quantitation results. Therefore many more cell conditions and samples can be analyzed than before. The Thoracic and GI Oncology Branch (TGIB)/CCR needs the resolution that this Mass Spectrometer provides for their scientific work in proteomics. (TGIB)/CCR's experiments demand the highest resolution because they use various labeling techniques for quantitation- SILAC and TMT labeling. All of this demands the highest resolution possible in a mass spectrometer and the higher resolution also improves quantization, which is the primary purpose of (TGIB)/CCR's proteomics experiments. The following salient characteristics apply to the Thermo Scientific TM Q Exactive TM HF hybrid quadrupole-Orbitrap mass spectrometer: • Features an ultra-high-field Orbitrap analyzer with Max Resolving Power 240,000 @ m/z 200 which doubles speed and resolution which is needed for TGIB's experiments. (This is the highest resolution known in a mass spectrometer) • Allows high throughput samples run. Scan rate up to 12 Hz at resolution setting of 17,500 @ m/z 200. • Provides Mass Accuracy: Internal: < 1 ppm RMS, and External: < 3 ppm RMS which improves quantitation results. Thermo Electron North Amercia, LLC will provide the Thermo Scientific TM Q Exactive TM HF hybrid quadrupole-Orbitrap mass spectrometer along with the ULTIMATE 3000 Binary RS nano-LC System. Thermo Electron North America is the sole manufacturer of the Q Exactive HF LC/MS/MS mass spectrometer. It is the only Quadrupole-Orbitrap benchtop mass spectrometer known in the world today delivering a maximum resolution of 240,000 (FWHM) at m/z 200 for all scan modes and polarities. This spectrometer features an ultra-high-field Orbitrap analyzer which doubles its speed and resolution and allows high throughput samples run and provides better quantitation results. Therefore many more cell conditions and samples can be analyzed than before. The Thoracic and GI Oncology Branch (TGIB)/CCR needs the resolution that this Mass Spectrometer provides for their scientific work in proteomics. (TGIB)/CCR's experiments demand the highest resolution because they use various labeling techniques for quantitation- SILAC and TMT labeling. All of this demands the highest resolution possible in a mass spectrometer and the higher resolution also improves quantization, which is the primary purpose of (TGIB)/CCR's proteomics experiments. This notice is not a request for competitive quotation. However, if any interested party, especially small businesses, believes it can meet the above requirement, it may submit a capability statement, proposal, or quotation, which shall be considered by the agency. The statement of capabilities and any other information furnished must be in writing and must contain material in sufficient detail to allow NCI to determine if the party can perform the requirement. Responses must be received in the contracting office by 11:00am EST, on September 4, 2015. All responses and questions must be in writing and faxed 240-276-5401or emailed to Terry Galloway, Contracting Officer via electronic mail at gallowaytl@mail.nih.gov. A determination by the Government not to compete this proposed requirement based upon responses to this notice is solely within the discretion of the Government. Information received will be considered solely for the purpose of determining whether to conduct a competitive procurement. No collect calls will be accepted. In order to receive an award, contractors must be registered and have valid certification in the Central Contractor Registration (CCR) and the Online Representations and Certifications Applications (ORCA) through sam.gov. Reference: N02RC54103-43 on all correspondence.
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- Record
- SN03860175-W 20150829/150828000730-0f6e03e0f95e3deeb12426eac39d2293 (fbodaily.com)
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