MODIFICATION
D -- Centralized Information Technology System for the NIH Blueprint Neurotherapeutics Network
- Notice Date
- 12/22/2015
- Notice Type
- Modification/Amendment
- NAICS
- 541519
— Other Computer Related Services
- Contracting Office
- Department of Health and Human Services, National Institutes of Health, National Institute on Drug Abuse, Station Support/Simplified Acquisitions, 31 Center Drive, Room 1B59, Bethesda, Maryland, 20892
- ZIP Code
- 20892
- Solicitation Number
- HHS-NIH-NIDA-SSSA-PSOL-2016-081
- Archive Date
- 1/26/2016
- Point of Contact
- Lauren M. Phelps, Phone: 3015942490
- E-Mail Address
-
lauren.phelps@nih.gov
(lauren.phelps@nih.gov)
- Small Business Set-Aside
- N/A
- Description
- SOLICITATION NUMBER: HHS-NIH-NIDA-SSSA-PSOL-16-081 NOTICE INFORMATION Title: CENTRALIZED INFORMATION TECHNOLOGY SYSTEM FOR THE NIH BLUEPRINT NEUROTHERAPEUTICS NETWORK Contracting Office Address: Department of Health and Human Services, National Institutes of Health, National Institute on Drug Abuse, Station Support Simplified Acquisitions, 31 Center Drive, Room 1B59, Bethesda, MD 20892, UNITED STATES. Introduction: This is a Pre-Solicitation Notice of Intent. This is NOT a solicitation for proposals, proposal abstracts, or quotations. A solicitation will be issued on a later date. The purpose of this pre-solicitation is to notify potential offerors that the National Institute on Drug Abuse (NIDA) intends to solicit proposals for a Centralized Information Technology System for the NIH Blueprint Neurotherapeutics Network from qualified contractors having the capability to perform the tasks identified in this pre-solicitation. This acquisition is a re-competition of the Centralized Information Technology System requirement of the NIH Blueprint Neurotherapeutics Network. The initial Centralized Information Technology System contract (HHSN271201100676P) was awarded in 2011 to Collaborative Drug Discovery, Inc. Requirement Background Information: The National Institutes of Health (NIH) Blueprint for Neuroscience Research, a consortium of 8 NIH Institutes and Centers that support neuroscience research, established the Blueprint Neurotherapeutics Network (BPN) as a pipeline between the typical endpoint of NIH-funded research and the beginning of industry drug development. The BPN provides neuroscience researchers with funding and access to a full range of industry-style drug development services and expertise. The program is intended for projects that can enter either at the Discovery stage, to optimize well-validated hit compounds through medicinal chemistry, or at the Development stage, to advance development candidates through Investigational New Drug (IND)-enabling toxicology studies and phase I clinical testing (See more at: http://grants.nih.gov/grants/guide/pa-files/PAR-14-293.html#sthash.jHGg7T0i.dpuf ). These projects may require medicinal chemistry optimization and contract research organization (CRO) support through phase I clinical testing. Each project is directed by a Lead Development Team (LDT) composed of the principal investigator (PI) and PI collaborators, industry consultants hired by NIH, and NIH staff. This team maps out a research strategy, including milestones, and oversees implementation by CROs. Bioactivity and efficacy studies are funded through an award to the PI; other research services are provided without cost to the PI through NIH contracts. Purpose and Objectives for the Requirement: The purpose of this acquisition is to provide the BPN with a centralized, web-based information technology (IT) system to collect and maintain data from BPN and other NIH-funded projects that will allow users to upload/import, review, download/export, analyze, and visualize chemical structures and bioactivity, pharmacology, and toxicology data. The centralized data system will collect and maintain data which includes, but is not limited to, information on the chemical analogs produced by NIH-funded contractors and PIs (including chemical structures) and data from bioactivity, pharmacology, and toxicology assays. The data will be reviewed and analyzed by members of an LDT, PIs, CROs, NIH-hired consultants, and NIH staff. Some of these users will require access to all projects, while other users must only have access to individual projects. The BPN currently has 8 ongoing projects but it is expected that additional projects will be added and some will be discontinued each year. The BPN anticipates reaching a steady state of 5-10 projects at a given time with 3-5 users per project. A contractor is required to provide software services for each BPN and NIH-funded project utilizing its centralized web-based IT system until each project has been discontinued and the contractor has facilitated the transfer of all data to the relevant PI according to instructions from the NIH Contracting Officer's Representative (COR). Project Tasks/Requirements: The Contractor shall provide a centralized, web-based, information technology (IT) database that will provide user-friendly interfaces for entering, uploading/importing, searching, downloading/exporting, and visualizing chemical structures and bioactivity, pharmacology, and toxicology data, as well as software technical support. The database shall come with thirty five (35) user licenses and be a customizable software product which meets the following specific requirements: 1. System Requirements a)The database must be hosted on the contractor's server. b)The database must be compatible with PC and Mac standard operating systems. c)The database system must be accessible via the internet and must operate on the most current versions of Internet Explorer, Firefox, Chrome, and Safari. It is expected the database will support teamwork between geographically dispersed collaborators. d)The database must be compliant with Federal Information Security Management Act (FISMA; see http://csrc.nist.gov/publications/PubsFIPS.html for FIPS 199 form, which defines the security level, and Certification and Accreditation Requirements for NINDS Contracts, for specific requirements). e)The database must be compliant with Section 508 of the Rehabilitation Act of 1973 (29 U.S.C. 794d), which requires that all electronic and information technology products and services developed, acquired, maintained, or used by any Federal department or agency are accessible to individuals with disabilities. The Section 508 provisions applicable to this solicitation are detailed in subparts 1194.21, 1194.22, 1194.23, and 1194.41, which can be viewed at http://www.access-board.gov/sec508/standards.htm. General information about Section 508 is available at http://www.section508.gov/. f)The contractor must provide complete database back up as well as system recovery as needed. Any data lost to system failure must be restored within 24 hours. g)The contractor must ensure the informatics system and database are available continuously twenty four (24) hours a day, seven (7) days per week. Availability may be interrupted for scheduled maintenance. Such interruptions shall be no longer than twelve (12) hours in duration and the scheduled maintenance shall ideally be performed overnight or on the weekends. In the event of an availability outage with no advanced warning, the outage shall not exceed two (2) hours. h)The contractor must provide at least 48 hours of notification for scheduled down time for server or database upgrade or maintenance. i)The database system must have a "Dual-Factor" authentication method for all users who access the system and must be compatible with NIST FIPS 201 Standards (Personal Identity Verification of Federal Employees and Contractors, http://csrc.nist.gov/groups/SNS/piv/index.html ). j)The database must offer role-level security features. k)The database must offer restriction of writing and viewing privileges by project. l)The database must offer the ability to build and modify user-specified reporting templates for project management, portfolio analysis, structure activity relationship (SAR) analysis, and decision prioritization. m)The database must support different methods of data input (e.g., text, tables, graphs, numeric data, text) as well as different file formats (e.g. Microsoft Office, XML). n)The database must allow searches by field, either independently or in combination with other fields. o)The database must be capable of linking tabular data and structural data via a common field, such as an identification number (i.e., a relational database). p)The database must offer a user-friendly interface (i.e., accessible to scientists without informatics expertise) for data upload and database querying. q)The database must allow upload and association of chemical or biological data from external sources and databases. r)The database must offer easy and flexible visualization of biological and chemical data from multiple perspectives. s)The database must date and time stamp uploaded/imported data 2. Chemistry-related requirements a)The database must be capable to upload and store chemical structures and other identifying information for up to 500,000 compounds. b)The database must be able to register compounds with unique ID numbers and assign sub ID batch numbers to different samples of the same compound. The system must also be able to register salts, acid compounds, and basic compounds. c)The database must be able to upload and represent chemical structures from various data types including but not limited to SMILES strings, InChI strings, SD files, and Mol files, among others. The software must display steroselective features of chemical structures, such as chiral centers and stereoisomers. d)The database must offer structure-based searching capacity, including the ability to search and easily sort by substructure and structural similarities. e)The database must have the ability to enter, store, and download physicochemical and analytic purity information that is linked to fields including compound ID number, chemical structure, lot number, and plate number. f)The database must offer tools for calculation of chemical formula, molecular weight, and other chemical properties such as logP, solubility, and polar surface area g)The database must offer the ability for individual users to register and draw unique structures 3. Biology-related requirements a)The database must be able to perform four parameter curve fits of titration response data based on the variable slope sigmoidal equation and using outlier exclusion. It must have the ability to calculate IC50/EC50 and max-fold values, and show concentration/dose-response curves. b)The database must be able to upload, store, and download data from bioactivity, pharmacokinetic, and toxicity assays that are linked to ID number, chemical structure, lot number, and, when applicable, plate and well number. c)The database must have the ability to blind compound identification for biological testing. d)The database must generate reports and download/export structural, chemical, and biological data in tabular (e.g., Excel) format. e)The database must be able to combine tables of different kinds of data (e.g., structural and activity data) in an easy-to-read format 4. Technical Support Specifications The Contractor shall provide technical support for installation, maintenance, troubleshooting, and upgrading of the database and software. Technical support staff shall be available to respond to requests and resolve technical issues within 24 hours of a request for support. The Contractor shall provide the following user training online: a)General training sufficient to orient general users to perform all basic tasks, including importing assay and chemical structure data. General training will be repeated as directed by the COR with the option of multiple sessions over the 5 year period. b)Advanced training for analysis of structure activity relationships and other chemistry features as well as compound registration will be provided online as needed. The Contractor shall provide documentation (user manual) to describe the use of all aspects of the application's functionality. This documentation must be made available electronically and user support contact information (contractor email and phone number) must be provided. As each project is completed, the Contractor shall assist the Contributor PI in downloading or transferring the data in a universal format that can be easily recognized for import and use by another informatics system or database, as instructed by the NIH COR. 5. Anticipated Usage The BPN anticipates initiating the award with approximately 8-10 projects that have existing data, which will need to be imported into the Contractor's system. Additional projects will be added and dropped out of the BPN program throughout each year and it is anticipated that 5-10 projects per year will require access to the system at any given time. The duration of these projects will depend on their achievement of milestones, which will be evaluated approximately every 6 months. The most successful projects may require regular access to the IT system for up to five years. The NIH might also initiate projects outside of the BPN. Each project will involve a team of geographically separated individuals of which the composition may change over time. Each project team will be composed of the following personnel who will need access to the IT system (estimates of numbers in parentheses): Contributor's lab members and their collaborators (5-10 for each project), consultants (3-6 for the entire BPN program), BPN chemistry contractor staff (2-4 for the entire BPN program), and NIH staff (5-15 for the entire BPN program). The anticipated number of system users will be a base of 10-25 individuals (consultants, chemistry contractors, and NIH staff) plus 5-15 additional individuals (Contributors) for each project. 6. Optional Requirements The Contractor shall provide five (5) options for increased quantity annually. Each option shall include five (5) additional system licenses. 7. Transition-In/Implementation The informatics system must be ready for data deposition and analysis within one month of contract award. The system must be fully operational and available thereafter. At the initiation of the award resulting from this solicitation, the BPN will provide the successful offeror with a list of existing projects, data in a standard format from those projects, and a list of users and their roles. The contractor shall import the existing data into the database system per project, provide users with the appropriate security levels, and train users on the system within one (1) week after contract award. 8. Transition-Out At the conclusion of the contract (base period or option period, as applicable), the Contractor shall place all BPN data into a universal format (e.g., CSV, Excel, SDF) that may be easily recognized for import and use by another informatics system or database according to the instructions of the NIH COR. This data shall be provided to the Government at the conclusion of the contract. 9. Reporting Requirements a)Quarterly Report The contractor shall provide a quarterly report about system performance metrics for each week of the reporting period, including: number of sessions logged, number of compounds and assay data points in the database, average structure search time, number of help desk inquiries, time spent by contractor assisting users or modifying templates, number of scheduled and unscheduled system outages, amount of time the system was unavailable to users. b)Final Report Upon final completion of the each contract period, the contractor shall submit a final report. The final report for the final contract period will take the place of the last quarterly report. Set-Aside Status: It is anticipated that the services will be acquired through a 100% Small Business Set-Aside under NAICS Code 541519. Anticipated Period of Performance: The period of performance shall be one (1) one-year base period and four (4) one-year option periods. Anticipated Contract Type: The NIDA anticipates the award of one (1) contract. It is anticipated that the contract type shall be firm fixed price. Request for Proposal Release Information: Request for Proposal (RFP) No. NIH-NIDA-SSSA-RFP-16-82 will be available electronically on or about January 11, 2016. The RFP shall be accessible through FedBizOpps at http://fedbizopps.gov. All information required for the submission of a proposal will be contained in or accessible through the RFP package. Responses to the RFP will be due on or about 30 days following RFP release. Offerors must submit a proposal for all Task Areas in order to be considered for award. WE ENCOURAGE ALL RESPONSIBLE SOURCES TO SUBMIT A PROPOSAL WHICH WILL BE CONSIDERED BY THE AGENCY. Notes: This notice does not commit the Government to award a contract. No collect calls will be accepted. No facsimile transmissions will be accepted. It is the Offeror's responsibility to monitor the above mentioned site for the release of the solicitation and any amendments.
- Web Link
-
FBO.gov Permalink
(https://www.fbo.gov/spg/HHS/NIH/NIDA-2/HHS-NIH-NIDA-SSSA-PSOL-2016-081/listing.html)
- Place of Performance
- Address: Bethesda, Maryland, 20892, United States
- Zip Code: 20892
- Zip Code: 20892
- Record
- SN03976722-W 20151224/151222235014-59be810b003f7d1bb9e72f62ce996d48 (fbodaily.com)
- Source
-
FedBizOpps Link to This Notice
(may not be valid after Archive Date)
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