SOLICITATION NOTICE
B -- Use of Mouse Knockout Models to Determine the Function of Insulin in Taste Bud Cells
- Notice Date
- 2/1/2016
- Notice Type
- Presolicitation
- NAICS
- 541380
— Testing Laboratories
- Contracting Office
- Department of Health and Human Services, National Institutes of Health, National Institute on Drug Abuse, 6001 Executive Boulevard, Room 4211 - MSC 9559, Bethesda, Maryland, 20892, United States
- ZIP Code
- 20892
- Solicitation Number
- HHS-NIH-NIDA-SSSA-2016-154
- Archive Date
- 2/25/2016
- Point of Contact
- Samantha A. Kelly, Phone: 3014028855
- E-Mail Address
-
samantha.kelly2@nih.gov
(samantha.kelly2@nih.gov)
- Small Business Set-Aside
- N/A
- Description
- PRE-SOLICITATION NOTICE OF INTENT INTRODUCTION: THIS IS A PRE-SOLICITATION NOTICE OF A PROPOSED CONTRACT TO ACTION. The National Institute on Drug Abuse (NIDA), Station Support Contracts and Simplified Acquisitions Branch (SS/SA) on behalf of the National Institute of Aging intends to negotiate and award a contract for the "Use of Mouse Knockout Models to Determine the Function of Insulin in Taste Bud Cells". EXTENT OF COMPETITION: This acquisition is full and open with no set-aside restrictions. NORTH AMERICAN INDUSTRY CLASSIFICATION SYSTEM (NAICS) CODE: The intended procurement is classified under NAICS code 541380 with a Size Standard of $15 Million. REGULATORY AUTHORITY: The resultant contract will include all applicable provisions and clauses in effect through the Federal Acquisition Circular (FAC) 2005-86-2 dated February 1, 2016. This acquisition is conducted under the procedures as prescribed in FAR subpart 12-Acquisition of Commercial Items at an amount not exceeding the simplified acquisition threshold ($150,000). DESCRIPTION OF REQUIREMENT: Background: The National Institute on Aging (NIA) is conducting a project to determine the function of insulin in the taste buds cells of the tongue by specifically deleting insulin in the taste bud cells of the tongue of mice but allowing for normal expression of insulin in the islets of Langerhans in the pancreas. Purpose and Objectives: The purpose of this requirement is to procure production services for three mouse models and produce a fourth mouse model in support of the subject project, which will help to determine the function of insulin in the taste buds cells of the tongue by specifically deleting insulin in the taste bud cells of the tongue of mice but allowing for normal expression of insulin in the islets of Langerhans in the pancreas. Period of Performance: Base Year: 04/01/2016 through 03/31/2017 Project Description: Project Requirements: Specifically, the Contractor shall provide the following services for mice that will be mated for up to three (3) months or until up to 25 tails have been genotyped: 1.The contractor is required to make three transgenic mouse models and provide at least one breeding pair of homozygous mice for each of these mouse models to NIA. 2.Contractor shall use sophisticated molecular biology tools and their expertise to determine how to do this exactly and will make the constructs to inject into the ES cell lines and then breed the mice to get at least one breeding pair of homozygous mice for each of the three mouse models. Mice of each model constitute a deliverable to the NIA. 3.The contractor will then cross two of these mouse models to produce a fourth mouse model and provide NIA with at least one breeding pair of mice homozygous for the two genes in question. The four mouse models shall be generated as follows: 1.Mouse Model # 1 Mouse model in which the insulin 1 gene is absent in the entire animal i.e. a conventional knockout of the insulin 1 gene. 2.Mouse Model # 2 Mouse model in which the insulin 2 gene is absent in the entire animal i.e. a conventional knockout of the insulin 2 gene. 3.Mouse Model # 3 Mouse model in which the insulin 2 gene is floxed in the entire animal i.e. a mouse that will allow NIA to make a conditional knockout of the insulin 2 gene. 4.Mouse Model #4 Contractor shall breed mouse model # 1 with mouse model #3 to generate mice that are homozygous for both mutations. Contractor shall provide the NIA with at least one breeding pair of mice that are homozygous for both transgenes. Deliverables: 1.Contractor shall provide monthly written reports at each major milestone for the testing procedures. 2.Contractor shall provide a mapping of the gene for each mouse model. 3.Contractor shall provide animal health certification reports that must be supplied with each shipment of mice to the NIA vivarium. These must include certification that mice are free of pinworm infection, as evidenced by Polymerase Chain Reaction (PCR) Assays. Data Rights: The National Institute on Aging shall have unlimited rights to and ownership of all deliverables provided under this purchase order including reports, recommendations, briefings, work plans and all other deliverables. This includes the deliverables provided under the basic purchase order and any optional task deliverables exercised by the contracting officer. In addition, it includes any additional deliverables required by contract change. The definition of "unlimited rights" is contained in Federal Acquisition Regulation (FAR) 27.401, "Definitions." FAR clause 52.227-14, "Rights in Data-General," is hereby incorporated by reference. CLOSING STATEMENT The solicitation will be issued on or about February 12, 2016, and bids or proposals will be tentatively due about 10 days after the solicitation release date. Potential offerors may request a copy of the solicitation from Samantha Kelly, Contract Specialist, electronically at Samantha.Kelly2@nih.gov. Please reference the solicitation number HHS-NIH-NIDA-SSSA-2016-154 on your electronic and fax request.
- Web Link
-
FBO.gov Permalink
(https://www.fbo.gov/spg/HHS/NIH/NIDA-01/HHS-NIH-NIDA-SSSA-2016-154/listing.html)
- Record
- SN04005762-W 20160203/160201233943-5586c1361fcc7fcef75a8dfe71b14842 (fbodaily.com)
- Source
-
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