SOLICITATION NOTICE
A -- ZIKA Effect of In-use conditions on recommended pesticide-treated clothing containing permethrin and Deet Repellants. - Formatted Copy of Post
- Notice Date
- 1/12/2017
- Notice Type
- Combined Synopsis/Solicitation
- NAICS
- 541712
— Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology)
- Contracting Office
- Department of Health and Human Services, Centers for Disease Control and Prevention, Acquisition and Assistance Field Branch (Pittsburgh), Post Office Box 18070, Cochrans Mill Road, Pittsburgh, Pennsylvania, 15236-0070
- ZIP Code
- 15236-0070
- Solicitation Number
- 2017-Q-66260
- Archive Date
- 2/3/2017
- Point of Contact
- Anthony Lyas, Phone: 4123866448, Larry E Guess, Phone: (412)386-6826
- E-Mail Address
-
alyas@cdc.gov, lfg6@cdc.gov
(alyas@cdc.gov, lfg6@cdc.gov)
- Small Business Set-Aside
- N/A
- Description
- Complete formatted copy of the Intent to Sole Source Posting. The Centers for Disease Control and Prevention intends to award a sole source firm fixed price purchase order to The University of Huston for the services as described on the below statement of work. Statement of Work Objective 1: The experimental design will consist of an environmental chamber fitted with 1) a hot plate to simulate skin temperature under a clothing swatch, 2) a full spectrum UV and visible lamp, and 3) an air sampling port for collection of airborne concentrations of DEET during the testing. A 12 x 12 x 12 inch Boekel Scientific stainless steel and glass environmental chamber. The chamber is small enough to place it within an existing Fisher Isotemp oven. The environmental conditions are: • Simulated skin temperature will be controlled using an electric hot plate within the sealed chamber. The swatches of treated clothing will be placed on top of the hot plate, likely with a paper filter between them. The lower and upper ranges of skin temperature will be 30 and 38 º C. According to Gonzales-Alonso et al. (1999), this is the range of skin temperature depending on the environmental and physical exertion. • Simulated wetting from sweat, to test for hydrolysis and reduced DEET vaporization, will be assessed by saturating a filter paper backing or the clothing itself with artificial sweat (Pickering Laboratories). The amount of sweat will be estimated from an average sweating rate of 2 mg/cm2/min (Keneflick et al., 2011). • Simulated sunlight and UV exposure, to assess photolysis, with be assessed using a 300-450 W full spectrum (360-870 nm) LED lamp array to expose the treated clothing swatches to an equivalent full sun exposure. The lamp distance will be adjusted to deliver a UV intensity of about 350 µW/cm2, based on similar testing by the US EPA (1999). The laundering conditions are: • Hand washed with mild liquid soap and air dried. • Machine washed in cold water and machine dried with no heat. Continuous air sampling for DEET will be conducted using a common air sampling and analysis methodology for semi-volatile organic (SVOC) pesticides using Tenax TA sample media and GC-MS. At the same time, a data logging, real-time photoionization detector (PID) will be used to evaluate the evaporation rate of DEET over time. The PID data will be adjusted using a correction factor (CF) from the air sampling and analysis, with CF = average air sampling concentration divided by average direct-reading concentration. The concentration over time for each test will be compared to the effective concentration of DEET required to repel mosquitoes, at 2 mg/m3 (w/v) or 0.26 ppm (v/v). Extraction and analysis of permethrin (isomers) and DEET, for evaluation of hydrolysis and photolysis, will be conducted using dichloromethane and GC-MS. Working linear standard curves for both permethrin and DEET will be established using reference standards (Sigma-Aldrich). The swatch size will be optimized to ensure quantification limits are exceeded for all analyses performed. The run time will also be optimized to ensure maximum effects are observed given the recommended effectiveness of DEET. TASKS TO BE PERFORMED Task 1. To review scientific literature to identify knowledge gaps in research on clothing treatments and insect repellant with emphasis on worker protection, Zika infection and ‘in use' factors. Task 2. To develop an experimental system and methods to test permethrin and DEET concentrations over time. Task 3. To test the effects of simulated in-use exposures on permethrin and DEET effectiveness. Task 4. To produce a report that details the study design, data collection, data analysis, and interpretation of the results. Task 5. To produce a draft manuscript of the research findings for submission to a peer-reviewed journal. GOVERNMENT FURNISHED MATERIALS NIOSH NPPTL operates a clothing laundering facility in Morgantown, WV. These services may be requested at no cost for the purpose of providing fabric conditioning of samples for this study. PERIOD OF PERFORMANCE The Contractor shall complete the technical effort specified under Section 4 - TASKS TO BE PERFORMED, within twelve (12) months after the effective date of the contract. The anticipated term of the contract, including time allowed for the simulated testing, data analysis and submission of the report is twelve (12) months after the effective date of the contract. PLACE OF PERFORMANCE Vendor's Location DELIVERABLES/REPORTING SCHEDULE The contractor shall provide the following deliverables to the Project Officer by the Due Dates given below. All electronic files should be delivered in MS Word format and provided via e-mail. The contractor will provide testing results, a final report, and a draft manuscript to the COR and CO Task Description Copies Start date Finish date Task 1 Literature Review Email 1/15/17 3/17/17 Task 2 Permethrin and DEET experimental system N/A 1/15/17 3/31/17 Task 3 Garment Testing N/A 4/1/17 8/1/17 Task 4 Report email 8/1/17 12/31/17 Task 5 Draft manuscript email 8/1/17 12/31/17 The contractor will demonstrate progress through prompt reply to email correspondence from the COR and CO. The contractor will be available for at least one on-site tour/evaluation to be scheduled according with the CO and contractors schedule and availability. TRAVEL None SPECIAL REQUIREMENTS None REFERENCE MATERIALS Banks, SD, Murray, N, Wilder-Smith, A and Logan JG (2014). Insecticide-treated clothes for the control of vector-borne diseases: a review on effectiveness and safety. Medical and Veterinary Entomology: 28 (Suppl. 1), 14-25. Bureau of Labor Statistics (BLS) (2016). Occupational Outlook Handbook. [Accessed March 2, 2016 via http://www.bls.gov/ooh]. Centers for Disease Control and Prevention (CDC) (2106a). Vector-Borne Diseases - At a Glance: Division of Vector-Borne Diseases. [Accessed March 2, 2016 via http://www.cdc.gov/ncezid/dvbd/]. Centers for Disease Control and Prevention (CDC) (2016b). Area with Zika. [Accessed March 2, 2016 via http://www.cdc.gov/zika/geo/]. Centers for Disease Control and Prevention (CDC) (2106c). New to Know-Zika Virus as of March 1. [Accessed March 2, 2016 via http://intranet.cdc.gov/connects/2016/02/05/new-to-know-zika-virus/]. Centers for Disease Control and Prevention (CDC) (2106d). Zika Virus Case Counts in the US - September 28, 2016 [Accessed September 28, 2016 via https://www.cdc.gov/zika/geo/united-states.html]. Environmental Protection Agency (EPA) (2016). Insect Repellents: Reducing Insect Bites. [Accessed March 2, 2016 via http://www.epa.gov/insect-repellents]. Fradin, MS (1998). Mosquitoes and Mosquito Repellents: A Clinician's Guide. Annals of Internal Medicine 128: 931-940. Fradin, MS and Day, JF (2002). Comparative Efficacy of Insect Repellents Against Mosquito Bites. New England Journal of Medicine 347: 13-8. González-Alonso, J, Teller, C, Andersen, SL, Jensen, FB, Hyldig, T and Nielsen, B (1999). Influence of body temperature on the development of fatigue during prolonged exercise in the heat. J Appl Physiol: 86:1032-1039 Hazardous Substances Data Bank (HSDB) (2016a). DEET. Environmental Fate and Transport. [Accessed March 2, 2016 via http://toxnet.nlm.nih.gov/cgi-bin/sis/search2/r?dbs+hsdb:@term+@DOCNO+1582]. Hazardous Substances Data Bank (HSDB) (2016b). Permethrin. Environmental Fate and Transport. [Accessed March 2, 2016 via http://toxnet.nlm.nih.gov/cgi-bin/sis/search2/f?./temp/~wq4c2t:3]. National Institute for Occupational Safety and Health (NIOSH) (2016a). Hazards to Outdoor Workers. [Accessed March 2, 2016 via http://www.cdc.gov/niosh/topics/outdoor/]. National Institute for Occupational Safety and Health (NIOSH) (2016b). NIOSH Fast Facts: Protecting Yourself from Ticks and Mosquitoes. Publication 2010-119. [Accessed March 2, 2016 via http://www.cdc.gov/niosh/docs/2010-119/]. Vaughn, MF, Funkhouser, SW, Lin, F-C, Fine, J, Juliano, JJ, Apperson, CS, and Meshnick, SR (2004). Long-lasting permethrin impregnated uniforms: A randomized-controlled trial for tick bite prevention. Am J Prev Med: 46(5) 473 - 480. WHO (2016). Information for travelers visiting Zika affected countries. [Accessed March 2, 2016 via http://www.who.int/csr/disease/zika/information-for-travelers/en/]. (End of Statement of Work) Zika is known to cause impaired growth and sever fetal birth defects. The first locally acquired Zika infection in the USA occurred in summer of 2016. CDCs Emergency Operations Center (EOC) has moved to a Level 1 activation - the highest level of activation. This research needs to begin as soon as possible in response to current threats. Dr. Phalen of the University of Houston - Clear Lake is an expert in the fields of exposure and personal protective equipment and is ready to start this work immediately. In September 2016, Dr. Phalen coauthored a manuscript with NIOSH/NPPTL scientists discussing the protection of workers from Zika virus disease. At that time NPPTL realized a significant gap in research on the longevity of insecticides during in-use conditions of elevated temperature, humidity, and sun exposure. Based on the manuscript, NPPTL decided to conduct research to address these knowledge gaps, some of which Dr Phalen provided research suggestions. Dr. Phalen, through his efforts to draft the manuscript, accumulated knowledge and experience that is directly related to design of the experimental protocol. An expert in analysis of evaporative gas using a real-time photoionization detector (PID) in conjunction with GC-MS analysis using Tenax TA sample media specified in EPA and NIOSH standard methods, Dr. Phalen has expertise with configuration, calibration, and interpretation of PID measurements and has a thorough understanding of the specificity of its application to this research. Given his knowledge, previous experience working with NIOSH/NPPTL on Zika related research, PID and understanding of the goals of the research project, Dr Phalen is uniquely prepared to start the proposed research. This is an urgent requirement. This contract action is for services for which the Government intends to solicit and negotiate with only one source under the authority of FAR 13.106-1(b) (SAP) and 41 U.S.C. 3304(a)(1).. Interested persons may identify their interest and capability to respond to the requirement or submit proposals. This notice of intent is not a request for competitive quotations; however, all quotations/responses received within seven days (7) days of the issuance of this notice will be considered by the government. A determination by the government not to compete this proposed contract based upon responses to this notice is solely within the discretion of the government. Information received will normally be considered solely for the purpose of determining whether to conduct a competitive procurement. Any quotation/response should be emailed to contract specialist Anthony Lyas at alyas@cdc.gov by COB January 19, 2017.
- Web Link
-
FBO.gov Permalink
(https://www.fbo.gov/spg/HHS/CDCP/CMBP/2017-Q-66260/listing.html)
- Place of Performance
- Address: University of Houston-Clear Lake 2700 Bay Area Blvd, Huston, Texas, 77058, United States
- Zip Code: 77058
- Zip Code: 77058
- Record
- SN04370862-W 20170114/170112234804-1dc9bd761965d8fcd688d6d549d7ed29 (fbodaily.com)
- Source
-
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