SOURCES SOUGHT
66 -- Mass Spectrometry Interpretation Software Package
- Notice Date
- 1/23/2017
- Notice Type
- Sources Sought
- NAICS
- 541990
— All Other Professional, Scientific, and Technical Services
- Contracting Office
- Department of Commerce, National Institute of Standards and Technology (NIST), Acquisition Management Division, 100 Bureau Drive, Building 301, Room B130, Gaithersburg, Maryland, 20899-1410, United States
- ZIP Code
- 20899-1410
- Solicitation Number
- NIST-MML-17-SS7
- Archive Date
- 2/21/2017
- Point of Contact
- Latish Walker, Phone: 3019750474, Grace H. Garrity, Phone: 3019752345
- E-Mail Address
-
latish.walker@nist.gov, grace.garrity@nist.gov
(latish.walker@nist.gov, grace.garrity@nist.gov)
- Small Business Set-Aside
- N/A
- Description
- This is a SOURCES SOUGHT NOTICE for market research purposes. THIS IS NOT A REQUEST FOR PROPOSALS. INFORMATION RECEIVED WILL BE USED FOR MARKET RESEARCH PURPOSES ONLY. After the results of this market research are obtained and analyzed, NIST may conduct a competitive procurement and subsequently award a contract. The National Institute of Standards and Technology (NIST)/Biomanufacturing Initiative includes development of a suite of fundamental measurement science, standards, and reference data to enable more accurate and confident characterization of key attributes of protein drugs. As part of that project, NIST has developed a monoclonal antibody into a NIST Reference Material. This material was released with physicochemical data as well as quantitative data traceable to fundamental units of measurement, and is expected to be utilized as a system suitability tool in the biopharmaceutical industry. NIST is currently seeking a mass spectrometry interpretation software package capable of processing high-resolution mass spectrometry data (originating from many different instrument vendor platforms) for intact glycoprotein analysis, peptide/glycopeptide mapping, and glycan mapping by mass spectrometry and MS/MS. In your response, please specifically address the capabilities of the proposed software to perform the functions detailed in the "Minimum Performance Specification" section. Potential vendors may also submit additional items deemed pertinent to robust characterization of glycoproteins and/or unique features of the software for analysis of glycoproteins using mass spectrometry. The following information is requested to be provided as part of the response to this sources sought notice. Vendors are encouraged, but not required, to address each of the following items. NIST will still consider responses which do not address all items below. Minimum Performance Specifications: 1. The proposed software shall be a single platform enabling intact mass deconvolution, peptide and glycopeptide matching/identification based on MS/MS, and matching/identification of released glycans based on MS/MS (with or without N-terminal labels). 2. The proposed software shall be capable of processing native raw data from numerous instrument vendors (including Agilent, Bruker, Thermo, SCIEX, Shimadzu, and Waters) as well as standard mzMXL format files. 3. The software shall allow three named users for simultaneous data searching and analysis. 4. The software shall be capable of data visualization in 2 dimensions (Retention time x MS1) as well as traditional 1D views. Results table shall be linked to observed peaks in 2D view. 5. The software shall be amenable to GXP compliance/FDA 21 CFR part 11 6. The software shall integrate with multiple search engines (e.g. Mascot, Sequest, etc.) 1. The software shall be amenable to a multi-attribute peptide mapping workflow, including: a. The software shall be capable of forming a composite peptide map reference trace averaged from replicate injections to be used as a comparator for future datasets. The composite reference trace shall be complete with retention time, detected m/z, and peak abundance information. b. The software shall be capable of automatic detection of new peaks (based on peak abundance, m/z, and retention time) when compared to the composite reference trace.
- Web Link
-
FBO.gov Permalink
(https://www.fbo.gov/spg/DOC/NIST/AcAsD/NIST-MML-17-SS7/listing.html)
- Record
- SN04378329-W 20170125/170123234656-ee22acd8a1ad796ea295060501f004b1 (fbodaily.com)
- Source
-
FedBizOpps Link to This Notice
(may not be valid after Archive Date)
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