SOLICITATION NOTICE
B -- Population-Based vs. Self-Selected Cohorts as the Source of Relative Risk Estimates by Smoking Status
- Notice Date
- 8/31/2017
- Notice Type
- Presolicitation
- NAICS
- 541990
— All Other Professional, Scientific, and Technical Services
- Contracting Office
- Department of Health and Human Services, National Institutes of Health, National Cancer Institute, Office of Acquisitions, 9609 Medical Center Drive, Room 1E128, Rockville, Maryland, 20852, United States
- ZIP Code
- 20852
- Solicitation Number
- N02CO72694-8
- Archive Date
- 9/22/2017
- Point of Contact
- Megan N. Kisamore, Phone: 2402765261
- E-Mail Address
-
megan.kisamore@nih.gov
(megan.kisamore@nih.gov)
- Small Business Set-Aside
- N/A
- Description
- Background The Department of Health and Human Services, National Institutes of Health, National Cancer Institute (NCI), Division of Cancer Control and Population Sciences (DCCPS), Surveillance Research Program (SRP) serves as the most authoritative source of information on cancer incidence, prevalence, mortality, and survival in the United States. Staff at NCI completed an interactive web site called "Know Your Chances: Interactive Risk Charts to Put Cancer in Context". The website can produce four types of charts: (1) Big Picture Charts which are similar to the static charts developed in Journal of the National Cancer Institute (JNCI) articles; (2) Custom Charts which allows the user to customize the causes of death and time horizon for the risks; (3) Your Chances Charts which allows the user to rank the causes of death for a specific age, race, and gender, and to compare the risks when the person was 10 years younger, and when the person will be 10 years older; and (4) Special Cancer Tables which present the risk of diagnosis and death for cancers in the time frame selected. In more recent work, risk estimates of causes of death by smoking status were developed. A key input into these calculations are estimates of the relative risk of death for smoking related causes of death by smoking status (current, former, and never smokers). The data source utilized for the relative risk estimates was the National Health Interview Surveys (NHIS) with mortality follow-up. This source was selected because it represents a population-based survey of the non-institutionalized population of the US. The more commonly used source of these relative risk estimates is the Combined Cohort (Carter et al., NEJM, 2015) consisting of the NIH-AARP, CPS II Nutrition, Health Professionals Follow-up Study, Nurses' Health Study, Women's Health Initiative cohorts. While the combined sample size of these studies is very large, the studies are not population-based; individuals select themselves to join the cohort; and, the cohorts are generally not as racially diverse as the US population. Independently, and not as an Agent of the Government, the Contractor shall furnish all the necessary services, materials, equipment, facilities and qualified personnel not provided by the Government, to perform the work outlined in the Statement of Work (SOW). This procurement includes comparing relative risk estimates from NHIS versus the Combined Cohort; assessing the estimates; and, providing NCI with recommendations to ultimately be used for website modifications to produce risk estimates by smoking status. This procurement does not include the modification of the Know Your Chances website. Contractor Requirements The Contractor shall perform the following tasks: 1.Employ an analytic strategy for developing relative risk estimates from NHIS to match the methodology used to develop net (in the absence of other cause) relative risk estimates from the combined cohort as described in Carter et al. (NEJM 2015). Note : Estimates should be developed for as many causes of death as samples sizes will permit, but at least all causes of death, coronary heart disease, stroke, high blood pressure, lung cancer, pancreatic cancer, colon and rectum cancer, stomach cancer, pneumonia/flu, diffuse atherosclerosis, aortic abdominal aneurysm, peripheral arterial disease, diabetes and COPD. Separate estimates to be developed by gender. 2.Access the NCHS Research Data Center (RDC) to obtain the NHIS estimates. Note : The RDC application should include both crude and net relative risk estimates, since crude relative risk estimates are used in as input in the Know Your Chances website, but net estimates are used for comparison to Carter et al. 3.Adjust/calibrate parameters in the existing statistical programs, for use at the RDC, to calculate and produce numbers that will eventually be incorporated into Know Your Chances website. Note : NCI will provide staff to visit the RDC and run the statistical programs. Resulting numbers shall be included in the report deliverable. 4.Prepare a report comparing the relative risk estimates and their standard errors from NHIS and the Combined Cohort. Note : Consideration should be given to the tradeoff between the presumably unbiased nature of the NHIS estimates, and the larger variance of the NHIS estimates than the substantially bigger Combined Cohort. 5.Develop estimates and prepare recommendations to be used as input for the Know Your Chances website, to ultimately provide risk estimates by smoking status. Place of Performance All work performed under the subject order shall take place at the Contractor's facility. Deliverables The following deliverables are required: -Written plan of how to develop NHIS relative risk estimates similar to those reported in Carter et al., the estimates and their standard errors, due 6 months after award -Written report comparing the relative risk estimates from NHIS and the Combined Cohort, laying out the strategy for adding risk by smoking status, and providing recommendations for website modifications to provide risk estimates by smoking status, due 12 months after award Unique Qualifications of the Contractor In collaboration with the NCI, faculty at the Department of Community and Family Medicine, Dartmouth Institute for Health Policy and Clinical Practice of Dartmouth College previously developed interactive risk charts for an interactive website called "Know Your Chances: Interactive Risk Charts to Put Cancer in Context. The recommended Contractor has completed services, in support of the NCI, to examine data sources and methodologies to estimate risk estimates. Only the recommended Contractor possesses the unique knowledge and experience related to the development, manipulation and dissemination of these charts, in addition to specialized technical familiarity on the rationale, implementation, interpretation, visual layout, and communication of comparative disease risk charts, which resulted in the four charts that are currently in use: (1) Big Picture Charts, which are similar to the static charts developed in JNCI articles; (2) Custom Charts, which allows the user to customize the causes of death and time horizon for the risks; (3) Your Chances Charts, which allows the user to rank the causes of death for a specific age, race, and gender, and to compare the risks when the person was 10 years younger, and when the person will be 10 years older; and (4) Special Cancer Tables, which present the risk of diagnosis and death for cancers in the time frame selected. The suggested source is required in order to apply equivalent analytic strategies to the required tasks. Any efforts provided via another source would produce results that are not scientifically comparable; would cause significant delays; and, could potentially compromise the outcome of the project. This notice is not a request for competitive quotation. However, if any interested party, especially small business believes it can meet the above requirement, it may submit a proposal or quote for the Government to consider. The response and any other information furnished must be in writing and must contain material in sufficient detail to allow NCI to determine if the party can perform the requirement. Responses must be received in the contracting office by 1:00 PM EST, on September 7, 2017. All responses and questions must be via email to Contracting Officer, Megan Kisamore, at megan.kisamore@nih.gov. A determination by the Government not to compete this proposed requirement based upon responses to this notice is solely within the discretion of the Government. Information received will be considered solely for the purpose of determining whether to conduct a competitive procurement. In order to receive an award, Contractors must be registered and have valid certification through SAM.GOV and have completed Representations and Certifications. Reference: N02CO72694-8 on all correspondence.
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