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FBO DAILY - FEDBIZOPPS ISSUE OF FEBRUARY 15, 2018 FBO #5928
DOCUMENT

66 -- Sources Sought-Ussing Station - Attachment

Notice Date

2/13/2018
 

Notice Type

Attachment
 

NAICS

334515 — Instrument Manufacturing for Measuring and Testing Electricity and Electrical Signals
 

Contracting Office

Department of Veterans Affairs;Network Contracting Office 2;James J. Peters VA Medical Center;130 West Kingsbridge Road;Bronx NY 10468-3904
 

ZIP Code

10468-3904
 

Solicitation Number

36C24218Q0253
 

Response Due

2/20/2018
 

Archive Date

5/21/2018
 

Point of Contact

Tina.Cavalieri@va.gov
 

E-Mail Address

tina.cavalieri@va.gov
(tina.cavalieri@va.gov)
 

Small Business Set-Aside

N/A
 

Description

THIS IS NOT A REQUEST FOR QUOTES OR PROPOSALS. The Government is seeking information for market research purposes only. Your responses to the information requested will assist the Government in determining the appropriate acquisition method. A solicitation is not currently available. The Government may or may not issue solicitation documents. The Department of Veterans Affairs, Veterans Integrated Service Network (VISN 2), is conducting market research for qualified firms, SDVOSB, VOSB and small businesses, that are capable of providing the following products, to the Northport Campus. This is for the Brand Name of the Ussing Chamber or Equal. Any vendor interested needs to be an authorized reseller. Any equal s must meet all technical specifications. No gray market items. Applicable NAICS Code is 334515, with a Small Business size standard of 750 Employees. Offerors desiring consideration shall email a capabilities statement and the following information directly to the Contracting Officer referencing the following in the subject field, 36C24218Q0253 Ussing Station. Offerors, at the time of response, shall be verified in SAM. Unverified Vendors will be considered non-responsive to the requirements of this sources sought and any resulting solicitation. Offers from unverified Vendors are considered deficient and will not be evaluated. Company Name: Socio-Economic Category: Street Address, City, State and Zip Code: DUNS Number: Point of Contact Name: Point of Contact Phone Number: Point of Contact E-mail Address: IMPORTANT NOTE: Responses to this Sources Sought notice must be submitted via e-mail (no phone calls) to the Contracting Officer's E-mail: tina.cavalieri@va.gov and received no later than February 20, 2018 @ 8AM. This is a market survey for informational and planning purposes only. THIS IS NOT A SOLICITATION AND DOES NOT OBLIGATE THE GOVERNMENT TO ISSUE A SOLICITATION. Please be advised that the Government will not pay for any information submitted under this announcement. Statement of Work-Ussing Chamber Background: Essential hypertension (eHTN) affects millions of adults in the U.S. and contributes to end organ damage including kidney failure. The epidemic of eHTN is, in part, related to environmental changes, and in particular, the high sodium (Na) and cholesterol (chol) diets consumed in the U.S. The link between Na consumption and eHTN is established; however, the relationship between chol and eHTN is not well understood. Chronic, long-term hypercholesterolemia leads to arteriolosclerosis and diminished vascular compliance predisposing to eHTN; however, recent evidence suggests that acute, short-term chol ingestion augments renal Na avidity to raise blood pressure (BP). Hypercholesterolemia promotes incorporation of chol into lipid rafts (LRs) of the plasma membrane (PM) which raises PM viscosity and induces diseases such as diabetes (by suppressing insulin secretion) and diabetic nephropathy. The contribution of chol to organ dysfunction is underscored by the observation that chol chelation by cyclodextrin improved insulin secretion and diabetic nephropathy while treatment with statins had no effect. We hypothesize that chol incorporation into the lipid rafts and plasma membrane of the kidney collecting leads to enhanced epithelial sodium channel dependent trans epithelial sodium transport which contributes to the development of hypertension. Objective: We seek to purchase an Ussing chamber, equipment that permits the measurement of trans epithelial currents, in order to test whether cholesterol incorporation into collecting duct epithelium enhances trans epithelial sodium transport. Place of Performance: Northport VAMC, Building 62. Travel: Not Applicable Special Material Requirements: Not Applicable Any Other Requirements unique to the solicitation: Not Applicable Scope of Tasks/Product Specifications: Our goal is to test whether cholesterol incorporation into the plasma membrane enhances trans epithelial Na transport in cortical collecting duct cells. The system we request is simpler to use and easier to generate data. See below for the details. The chamber stand and chamber system use the Easy mount approach provides a simple slot for a specific slider to easily be inserted into or removed from the chamber very easily and quickly. Each chamber is independent therefore if one has a small leak due to improper mounting you will only need to manage the single chamber not the entire system. The Individual chamber cradle approach lends itself to vert fast and easy cleanup. The voltage current clamp is the only type that has a gain and fluid resistance adjustment (Optigain adjustment) on the main panel to allow easy adjustment from very small surface area 0.002 cm2 to large surface area 1.26 cm2 with a quick and easy click of a dial switch. Physiologic Instruments software (Acquire and Analyze) has many advantages as well: Acquire & Analyze is designed specifically for trans epithelial electrophysiology. It is not intended to be used as a general purpose instrument. Its custom features permit concomitant recording of voltage and current from up to 8 voltage/current clamp channels, and it imposes a command signal across the epithelium to calculate and plot trans epithelial resistance in real time. This feature alone is a significant benefit over the PowerLab, which in the case of Powerlab requires an individual to post process using manual input to calculate TEER or conductance at each time of interest -- very time consuming! Acquire and Analyze data acquisition is easy to initiate and requires only a selection of a new file name and few clicks of Ok for setup. Data collection rate is easily selected from 3 user defined icons (slow, medium and fast -- typically once every 1, 10 or 20 sec, respectively) by a simple click on the icon before or even during an experiment. If one selects 10 sec, the trans epithelial voltage, current and resistance or conductance on each tissue are measured and stored once every 10 s. This yields very small data files relative to the files created when using PowerLab. This difference is due to Powerlabs continuously sampling at a high rate to capture all pulses imposed across the epithelium. Thus, to minimize memory requirements A&A files are small and contain only pertinent information, while PowerLab file are large and contain a lot of redundant information between the relevant data points for these kinds of experiments.
 

Web Link

FBO.gov Permalink
(https://www.fbo.gov/spg/VA/BroVANAP/VAMD/36C24218Q0253/listing.html)
 

Document(s)

Attachment
 

File Name: 36C24218Q0253 36C24218Q0253.docx (https://www.vendorportal.ecms.va.gov/FBODocumentServer/DocumentServer.aspx?DocumentId=4083310&FileName=36C24218Q0253-000.docx)

Link: https://www.vendorportal.ecms.va.gov/FBODocumentServer/DocumentServer.aspx?DocumentId=4083310&FileName=36C24218Q0253-000.docx

 

Note: If links are broken, refer to Point of Contact above or contact the FBO Help Desk at 877-472-3779.
 

Record

SN04821477-W 20180215/180213231524-477de9a1e7682313dfeeccef0e7ee33c (fbodaily.com)
 

Source

FedBizOpps Link to This Notice
(may not be valid after Archive Date)

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