SOURCES SOUGHT
66 -- Synthesis Reactor with mobile reactor suite and high-performance chiller
- Notice Date
- 8/1/2018
- Notice Type
- Sources Sought
- NAICS
- 334516
— Analytical Laboratory Instrument Manufacturing
- Contracting Office
- Department of Health and Human Services, National Institutes of Health, National Institute on Drug Abuse, 6001 Executive Boulevard, Room 4211, MSC 9559, Bethesda, Maryland, 20892-9559, United States
- ZIP Code
- 20892-9559
- Solicitation Number
- NIHDA201800404
- Archive Date
- 8/23/2018
- Point of Contact
- Hunter A Tjugum, Phone: 3018275304
- E-Mail Address
-
hunter.tjugum@nih.gov
(hunter.tjugum@nih.gov)
- Small Business Set-Aside
- N/A
- Description
- INTRODUCTION This is a Small Business Sources Sought (SBSS) notice. This is NOT a solicitation for proposals, proposal abstracts, or quotations. The purpose of this notice is to obtain information regarding: (1) the availability and capability of qualified small business sources; (2) whether they are small businesses; HUBZone small businesses; service-disabled, veteran-owned small businesses; 8(a) small businesses; veteran-owned small businesses; woman-owned small businesses; or small disadvantaged businesses; and (3) their size classification relative to the North American Industry Classification System (NAICS) code for the proposed acquisition. Your responses to the information requested will assist the Government in determining the appropriate acquisition method, including whether a set-aside is possible. An organization that is not considered a small business under the applicable NAICS code should not submit a response to this notice. This notice is issued to help determine the availability and type of qualified Small Business companies technically capable of meeting this potential government requirement and to determine the method of acquisition. It is not to be construed as a commitment by the Government to issue a solicitation or ultimately award a contract. Responses will not be considered as proposals or quotes. No award will be made as a result of this notice. The Government will NOT be responsible for any costs incurred by the respondents to this notice. The notice is strictly for research and information purposes only. The information requested will assist the Government in determining the appropriate acquisition method including small business socio-economic set-aside possibilities and to determine the availability of qualified Small Business companies technically capable of meeting the Government's potential requirement. All Small Business companies with the capability and availability to perform the requirement under the applicable NAICS code are invited to submit a response to this notice. NORTH AMERICAN CLASSIFICATION SYSTEM (NAICS) CODE The NAICS code applicable to this requirement is 334516 Analytical Laboratory Instrument Manufacturing with size standard 1000 employees. BACKGROUND The National Center for Advancing Translational Sciences (NCATS) at the National Institutes of Health (NIH) was officially established in fiscal year 2012 to transform the translational science process so that new treatments and cures for disease can be delivered to patients faster. NCATS, one of 27 Institutes and Centers (ICs) at NIH, strives to develop innovations to reduce, remove or bypass costly and time-consuming bottlenecks in the translational research pipeline in an effort to speed the delivery of new drugs, diagnostics and medical devices to patients. The Division of Pre-Clinical Innovation (DPI) at NCATS plans, conducts and uses both internal and contract resources to advance collaborative research projects across the pre-clinical phases of the translational science spectrum. Specifically, this division: Plans, conducts and collaborates on research to develop new methods and technologies to enhance pre-clinical processes; Plans, conducts and collaborates on research to evaluate existing and developing approaches, technologies, and processes in the pre-clinical spectrum; Supports training programs relevant to pre-clinical phases of translational science; Allocates DPI resources to pre-clinical extramural and intramural investigators; Collaborates with other NIH Institutes and Centers and the scientists they support; Consults with stakeholders, including patients, industry and regulators. The DPI shall use this equipment to support novel assay development and validation screening by completing the synthesis of target small molecules. The reactor module shall be designed to run eight completely independent reactions at a reactions scales typical for support complex multi-step syntheses. The independent control of each reactor well shall provide both reaction optimization and diverse reaction execution typical of medicinal chemistry benches is possible and further facilitated through programmable automation routines. The programming of reaction recipes shall provide that reactions can be more precisely started and stopped, reagents can be more accurately dosed, and overall conditions more precisely reproduced across eight reactions at once. Purpose and Objectives This Small Business Sources Sought notice seeks to determine eligible sources capable of achieving the essential features of this potential requirement to obtain a Synthesis Reactor with mobile reactor suite and high-performance chiller containing the specifications described in this notice. The purpose of this potential requirement is to obtain one (1) All-in-One Synthesis Reactor that combines with independent temperature control, high-performance chiller, mobile reactor cart, virtual chemist software, onsite maintenance, operator training and quarterly preventive maintenance visits and warranty in accordance with standard commercial practices. DPI labs are in need of a complex All-in-One Reactor with High Performance Chiller in order to improve the synthesis of small molecules targeted for biological screening. Such an apparatus will improve overall synthesis throughput, improve output quality and expand the breadth of synthetic targets as well. By integrating additional machine control that can be programmed and remotely monitored, more precise and reproducible results are expected to be produced. In addition, walk-away time afforded by automating protocols will allow chemists to focus on more complex intellectual pursuits associated with the research. The instrument is precisely poised to support particularly demanding reaction protocols (rigorously inert conditions, both high and low temp control, strong mixing, reaction monitoring and temporal reagent delivery). Project Requirements Contractors submitting a response to this Small Business Sources Sought notice shall possess the ability to achieve the essential government features specified herein. Offerors to this Small Business Sources Sought notice shall document evidence of being able to provide the subject requirement. The essential features of the Synthesis Reactor that need to be met by this potential requirement include an All-in-one Reactor with independent temperature control and high-performance chiller; Mobile Reactor Cart; Virtual Chemist GUI Software; Onsite maintenance and operator training; Quarterly scheduled preventative maintenance visits; One Package of Individual MRV Adapters; One Package of Individual Replacement Seal Modules; Vacuum & Waste Pump Out Unit; High Pressure Supply System and Acetone Cabinet System. The Synthesis Reactor with mobile reactor suite and high-performance chiller will include an integration of multiple functions/devices into a single system that must be able to: 1. Provide reduced vial transfers between equipment; 2. Perform multiple functions simultaneously (heating, reflux, stirring, N2 pressurization); 3. Provide significant reduction in bench space, footprint, and complexity, possessing the ability to: a. Run up to 8 pre-programmed reaction cycles with unique parameters simultaneously; perform remote monitoring and control of all parameters, via standard communications interface; b. Run temperature-controlled reactions with set-points from -40°C to 150°C; c. Run sealed and heated reactions with reflux, for zero-loss boiling reactions; d. Posess automatic vacuum evacuation and nitrogen purge of reaction vessel; e. Posess automatic sanitization of reactor lid between reaction cycles to prevent contamination; f. Add reagents to any individual vial, at any time during a reaction cycle; 4. Thoroughly mix reagents with magnetic bar stirring using standard bars from 200 rpm to 1500 rpm; 5. Remove any individual vial, at any time during a reaction cycle; 6. Posess tool-less removal of reaction chamber liner, for containment and cleanup of explosive reactions; 7. Provide standardization of chemistries from discovery to production with industry standard vials (two MRV sizes (2-5mL and 10-20mL) must be accommodated using removable MRV adapters); 8. Posess independent heating/cooling/reflux control (per lane); 9. Posess independent pressurization/vacuum control; 10. Defrost, condensation purge, waste lift pump; 11. Posess full-range chemical compatibility; 12. Posess API structure for Automation Communication; 13. Posess Automated Recipe Handling and a safety system. Delivery: Offerors should indicate an estimated delivery time in full after receipt of an order and any other training or factory warranty schedules in accordance with standard commercial practice, as applicable. Inspection and acceptance will be performed at a Government facililty located at 9800 Medical Center Drive, Rockville, MD 20850. CAPABILITY STATEMENTS SOUGHT Interested parties are expected to review this notice to familiarize itself with the requirements of this project. Failure to do so will be at your firm's own risk. Respondents must provide, as part of their response: (a) product, catalog, model, and/or part number(s); (b) product description; (c) all relevant information and documentation that the item(s) offered meets the salient physical, functional, or performance characteristics as specified in this announcement; (d) quantity; (e) shipping, handling, and/or installation instructions, and/or any special delivery conditions after receipt of an order. Respondents that believe that they are manufacturers or authorized re-sellers of the equipment specified in this announcement must provide, as part of their response: (a) product, catalog, model, and/or part number(s); (b) product description; (c) all relevant information and documentation that the item(s) offered meets the salient physical, functional, or performance characteristics as specified in the purchase description; (d) quantity; (e) estimated price or cost; (f) shipping, handling, and/or installation charges; and delivery date after receipt of order. The respondent must also provide their DUNS number, organization name, address, point of contact, and size and type of business (e.g., 8(a), HubZone, etc.) pursuant to the applicable NAICS code and any other information that may be helpful in developing or finalizing the acquisition requirements. The information submitted must be in outline format that addresses each of the elements of this requirement. A cover page and an executive summary may be included but is not required. The response is limited to ten (10) pages. The 10-page limit does not include the cover page, executive summary, or references, if requested. The response must include the respondents' technical and administrative points of contact, including names, titles, addresses, telephone and fax numbers, and e-mail addresses. Respondents must reference the subject announcement number on all correspondence related to this Small Business Sources Sought notice. The response must be submitted to Hunter Tjugum electronically, at hunter.tjugum@nih.gov, and be received prior to the closing date specified in this announcement. CONCLUDING STATEMENTS Disclaimer and Important Notes. This notice does not obligate the Government to award a contract or otherwise pay for the information provided in response. The Government reserves the right to use information provided by respondents for any purpose deemed necessary and legally appropriate. Any organization responding to this notice should ensure that its response is complete and sufficiently detailed to allow the Government to determine the organization's qualifications to perform the work. Respondents are advised that the Government is under no obligation to acknowledge receipt of the information received or provide feedback to respondents with respect to any information submitted. After a review of the responses received, a pre-solicitation synopsis and solicitation may be published in Federal Business Opportunities. However, responses to this notice will not be considered adequate responses to a solicitation. Confidentiality. No proprietary, classified, confidential, or sensitive information should be included in your response. The Government reserves the right to use any non-proprietary technical information in any resultant solicitation(s).
- Web Link
-
FBO.gov Permalink
(https://www.fbo.gov/spg/HHS/NIH/NIDA-01/NIHDA201800404/listing.html)
- Record
- SN05015892-W 20180803/180801231456-73563a83687277f00351513eb4aa565e (fbodaily.com)
- Source
-
FedBizOpps Link to This Notice
(may not be valid after Archive Date)
| FSG Index | This Issue's Index | Today's FBO Daily Index Page |