SOURCES SOUGHT
66 -- Electrophysiology Amplifiers, Digitizers, and Software - Sources Sought 5014427
- Notice Date
- 8/22/2018
- Notice Type
- Sources Sought
- NAICS
- 334516
— Analytical Laboratory Instrument Manufacturing
- Contracting Office
- Department of Health and Human Services, National Institutes of Health, National Institute on Drug Abuse, 6001 Executive Boulevard, Room 4211, MSC 9559, Bethesda, Maryland, 20892-9559, United States
- ZIP Code
- 20892-9559
- Solicitation Number
- NIHDA201800494-SS
- Archive Date
- 9/11/2018
- Point of Contact
- Valerie Whipple, , Danielle R. Brown, Phone: 301 480 2385
- E-Mail Address
-
valerie.whipple@nih.gov, danielle.brown2@nih.gov
(valerie.whipple@nih.gov, danielle.brown2@nih.gov)
- Small Business Set-Aside
- N/A
- Description
- Sources Sought 5014427 - Electrophysiology Amplifiers, Digitizers, and Software The purpose of this order is to procure amlifiers, digitizers, and software with increased signal to noise ratio to detect electrophysiological methods that are typically very small in size (µV or pA). The unit on Neuromodulation and Synaptic Integration (NSI) is a new laboratory being established at the NIMH. This laboratory will utilize cutting-edge electrophysiological studies to determine how information is processed by the brain at the cellular, microcircuit, and systems levels to ultimately understand the computations that drive physiological behavior and psychiatric disorders. We utilize whole-cell slice electrophysiology in combination with other techniques, including optogenetics, UV uncaging, transgenic mice, viral approaches, and pharmacology to dissect how synapses and intrinsic factors that control excitability in neurons are regulated by receptors that are implicated in psychiatric disorders and are the major target of most pharmacological treatments for this disease. Electrophysiology is currently the only tool that allows neuroscientists to study synapses and intrinsic factors that control excitability with sub-millisecond temporal and single cell resolution. Electrical signals detected by electrophysiological methods are typically very small in size (µV or pA) and need cutting-edge electronics (amplifier, digitizer, and software) with increased signal to noise ratio to achieve this. As the NSI will utilize whole-cell slice electrophysiology as a means to dissect the function of neuronal circuits implicated in psychiatric disorders, we seek to acquire four electrophysiology amplifiers, digitizers, and data software packages with all the components necessary to successfully execute this cutting-edge technique.
- Web Link
-
FBO.gov Permalink
(https://www.fbo.gov/spg/HHS/NIH/NIDA-01/NIHDA201800494-SS/listing.html)
- Place of Performance
- Address: 6001 Executive Blvd, Rockville, Maryland, 20852, United States
- Zip Code: 20852
- Zip Code: 20852
- Record
- SN05050821-W 20180824/180822231256-49ddc9383e2a9aa43602d47f59958d55 (fbodaily.com)
- Source
-
FedBizOpps Link to This Notice
(may not be valid after Archive Date)
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