SPECIAL NOTICE
66 -- MASS SPECTROMETER
- Notice Date
- 9/6/2018
- Notice Type
- Special Notice
- NAICS
- 334516
— Analytical Laboratory Instrument Manufacturing
- Contracting Office
- Department of Commerce, National Institute of Standards and Technology (NIST), Acquisition Management Division, 100 Bureau Drive, Building 301, Room B130, Gaithersburg, Maryland, 20899-1410, United States
- ZIP Code
- 20899-1410
- Solicitation Number
- NIST-MML-18-SS16
- Archive Date
- 10/5/2018
- Point of Contact
- Wendy Paulo, Phone: 3019753976
- E-Mail Address
-
Wendy.Paulo@nist.gov
(Wendy.Paulo@nist.gov)
- Small Business Set-Aside
- N/A
- Description
- This is a SOURCES SOUGHT NOTICE for market research purposes only. THIS IS NOT A REQUEST FOR PROPOSALS OR A REQUEST FOR QUOTATIONS. The National Institute of Standards and Technology (NIST), Material Measurement Laboratory (MML), Biomolecular Measurement Division (BMD) in Gaithersburg, MD is planning to acquire a mass spectrometer system capable of generating high quality tandem mass spectra of ions generated by electrospray ionization for a very wide range of ion classes and fragmentation modes. NIST is seeking responses from all responsible sources, including large, foreign, and small businesses. Small businesses are defined under the associated NAICS code for this effort, 334516, as those domestic sources having 1,000 employees or less. Please include your company's size classification and socio-economic status in any response to this notice. Note that 13 CFR § 125.6 is applicable to this procurement, and as such, would need to comply with the limitations on subcontracting or qualify as a non-manufacturer (see https://www.sba.gov/contracting/contracting-officials/non-manufacturer-rule/non-manufacturer-waivers). If a small business cannot meet the requirements of 13 CFR § 125.6 in response to the below requirements, it should indicate so in its response. The mass spectrometer shall acquire spectra for many applications including: building mass spectrum reference libraries of all precursor ions of selected pure compounds under the most widely applied fragmentation modes; analysis of all ions arising from protein digests in order to identify of as many number and variety peptides with high quality spectra as possible; and to acquire good quality spectra for all ionized components in mixtures of metabolites and other mixtures of small molecules including environmental samples and food extracts. Given the spectra that must be acquired, the relative concentrations over a wide range for selected ions, and the range of samples that must be examined, the required system must have the ability to perform in the following manner: 1.Generate reliable spectra for the scientific community with the employment of two fragmentation methods: a beam-type collision cell at selectable collision energies and an ion trap capable of producing multistage fragmentation. The instrument must also be capable of passing ions between the ion trap and beam-type collision cell. 2.Capable of performing multi-level fragmentation in the ion trap. 3.Select ions for study at sub 1 Dalton level required for the analysis of ions in very complex mixtures containing isobaric contaminants. 4.Fragment ions from one fragmentation device by another that is required for identification of classes of ions such as glycopeptides, glycans and small molecules. 5.Perform accurate quantitative analysis of isobaric coded tags, such as iTRAQ (Isobaric tags for relative and absolute quantitation) and TMT (tandem mass tags) technologies, requires isolation and fragmentation of an ion of the highest intensity to avoid contamination artefacts. 6.Operate in both the nanospray and conventional mode since the instrument is to be used for proteomic and metabolomics experiments. This may require instrument reconfiguration. 7.Does not need to perform electron transfer dissocation (ETD) or come equipped with a nitrogen generator. 8.Include a UPS compatible with the instrument Instrument Characteristics: 1.The mass spectrometer must contain multiple ion fragmentation and detection devices. 2.Must be equipped with a complete nanoLC system with all components required for nanospray. 3.All components required for electrospray other than the LC system shall be included. 4.Sensitivity of 100 fg reserpine leading to 200:1 S/N for fragmentation to major ions 5.MS2 maximum scan rate of at least 12 Hz and up to 20 Hz 6.Minimum mass of 50 Da or lower 7.Maximum resolution equal to 500,000 at 200 m/z or higher 8.Mass accuracy of 1 ppm or lower using internal standard 9.Dynamic intrascan range of at least 5,000 10.Low mass ions (50-500 Da) for fragmentation must be isolatable within 0.2 m/z. Installation and Training: The system shall be installed by the contractor. Installation, at a minimum, shall include uncrating/unpackaging of all equipment, rigging (as appropriate), setup and hook-up of the system, demonstration of all specifications, and removal of trash. Onsite training shall be provided at NIST, Gaithersburg, MD and shall be completed not later than 30 days after delivery. INSTRUCTIONS TO RESPONDERS: Companies that are capable of providing this mass spectrometer are requested to email a detailed report describing their abilities to Wendy.Paulo@nist.gov no later than the response date for these sources sought notice. The report should include achievable specifications and any other information relevant to your product or capabilities. Also, the following information is requested to be provided as part of the response to this sources sought notice: 1.Name of the company(s) that offer the required supply. In addition, provide a point of contact for the company(s). 2.Business Size in accordance with NAICS code 334516. 3.Indication of number of days, after receipt of order that is typical for delivery. 4.Rough estimate of pricing (if available, not required); and 5.Any other relevant information that is not listed above which the Government should consider in developing its minimum specifications and finalizing its market research.
- Web Link
-
FBO.gov Permalink
(https://www.fbo.gov/spg/DOC/NIST/AcAsD/NIST-MML-18-SS16/listing.html)
- Place of Performance
- Address: 100 BUREAU DRIVE, GAITHERSBURG, Maryland, 20899, United States
- Zip Code: 20899
- Zip Code: 20899
- Record
- SN05076705-W 20180908/180906232457-06406d6fd78d2e9925d8b79ac28d80c0 (fbodaily.com)
- Source
-
FedBizOpps Link to This Notice
(may not be valid after Archive Date)
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