SOURCES SOUGHT
A -- NINDS Preclinical Screening Platform for Pain (PSPP)
- Notice Date
- 9/28/2018
- Notice Type
- Sources Sought
- NAICS
- 541715
— Research and Development in the Physical, Engineering, and Life Sciences (except Nanotechnology and Biotechnology)
- Contracting Office
- Department of Health and Human Services, National Institutes of Health, National Institute on Drug Abuse, 6001 Executive Boulevard, Room 4211, MSC 9559, Bethesda, Maryland, 20892-9559, United States
- ZIP Code
- 20892-9559
- Solicitation Number
- HHS-NIH-NIDA-SBSS-18-08
- Archive Date
- 10/30/2018
- Point of Contact
- Rieka Plugge, Phone: (301) 827-7515
- E-Mail Address
-
rieka.plugge@nih.gov
(rieka.plugge@nih.gov)
- Small Business Set-Aside
- N/A
- Description
- This is a Sources Sought notice. This is NOT a solicitation for proposals, proposal abstracts, or quotations. The purpose of this notice is to obtain information regarding the availability and capability of qualified sources to perform a potential requirement. This notice is issued to help determine the availability of qualified companies technically capable of meeting the Government requirement and to determine the method of acquisition. It is not to be construed as a commitment by the Government to issue a solicitation or ultimately award a contract. Responses will not be considered as proposals or quotes. No award will be made as a result of this notice. The Government will NOT be responsible for any costs incurred by the respondents to this notice. This notice is strictly for research and information purposes only. Background : The National Institute of Neurological Disorders and Stroke (NINDS) is seeking to establish a research contract for its Preclinical Screening Platform for Pain (PSPP) program in response to the Helping to End Addiction Long-term (HEAL) initiative, which the National Institutes of Health (NIH) launched in April 2018. The HEAL initiative (https://www.nih.gov/research-training/medical-research-initiatives/heal-initiative) is a trans-NIH effort to fast-track basic, translational, and clinical research in the field of addiction and pain to address the national opioid crisis. Purpose and Objectives : The NINDS is seeking to identify small business concerns with established expertise in pain models who could propose a plan to assess pain therapeutics in their labs or facilities with available access to resources and qualified expertise to establish new pain models as needed. The NINDS is also seeking sources that can provide data on potential side effects (in vitro and in vivo), drug abuse liability, in vitro pharmacological profiling and target selectivity, ADME (in vitro and in vivo) profiling, formulation research studies and pharmacokinetic studies of the investigational agents. The PSPP program shall establish a screening platform to test investigational agents/interventions (small molecules, biologics, natural products, devices) in a battery of in-vivo models of pain conditions to identify new non-opioid agents for further preclinical and clinical development. Investigational agents shall be submitted to the contractor in a blinded fashion and testing shall be performed (as directed by NINDS staff) in a series of acute and chronic pain models. Selected testing models of tolerability/side effect liability shall be also performed to determine therapeutic index. Additional testing in models of abuse liability shall also be investigated to evaluate the test agents for addictive potential. Project requirements : The Contractor shall evaluate new investigational agents under the following anticipated performance areas: 1) In-vivo testing in pain conditions, abuse liability and side effects assessment models; 2) In-vitro pharmacological profiling against opioid receptors and/or other molecular target(s) of safety concerns; 3) ADME & formulation studies and in-vivo pharmacokinetic (PK) assessment, and; 4) The Contractor may be required to perform supporting studies or establish new pain-related models to support the evolving requirements of the PSPP as needed. Capability statement /information sought : Respondents must provide clear and convincing documentation of their capability of providing the goods and/or services specified in this notice. Also, information must be provided in sufficient details of the respondents' (a) staff expertise, including their availability, experience, formal and other training; (b) current in-house capability to perform the work; (c) prior completed projects of similar nature; (d) corporate experience and other management capability; and (e) examples of prior completed Government contracts, references, and other related information. The respondent must also provide their DUNS number, organization name, address, point of contact, and size and type of business (e.g., 8(a), HubZone, etc., pursuant to the applicable NAICS code and any other information that may be helpful in developing or finalizing the acquisition requirements. Finally, respondents are also encouraged to provide a general overview of the respondent's opinions about the difficulty and/or feasibility of the potential requirement, and any other information regarding innovative ideas or concepts that may be applicable. Submission Instructions : The information submitted must be in an outline format that addresses each of the elements of the project requirement and in the capability statement /information sought paragraphs stated herein. A cover page and an executive summary may be included but is not required. The response is limited to ten (10) page limit. The 10-page limit does not include the cover page, executive summary, or references, if requested. The response must include the respondents' technical and administrative points of contact, including names, titles, addresses, telephone, and e-mail addresses. All responses to this notice must be submitted electronically to the Contract Specialist, Rieka Plugge, at rieka.plugge@nih.gov. Facsimile responses are NOT accepted. The response must be received on or before 10/15/2018 at 9:00 a.m., Eastern Standard Time. "Disclaimer and Important Notes: This notice does not obligate the Government to award a contract or otherwise pay for the information provided in response. The Government reserves the right to use information provided by respondents for any purpose deemed necessary and legally appropriate. Any organization responding to this notice should ensure that its response is complete and sufficiently detailed to allow the Government to determine the organization's qualifications to perform the work. Respondents are advised that the Government is under no obligation to acknowledge receipt of the information received or provide feedback to respondents with respect to any information submitted. After a review of the responses received, a presolicitation synopsis and solicitation will be published in Federal Business Opportunities. However, responses to this notice will not be considered adequate responses to a solicitation. Confidentiality : No proprietary, classified, confidential, or sensitive information should be included in your response. The Government reserves the right to use any non-proprietary technical information in any resultant solicitation(s)."
- Web Link
-
FBO.gov Permalink
(https://www.fbo.gov/spg/HHS/NIH/NIDA-01/HHS-NIH-NIDA-SBSS-18-08/listing.html)
- Record
- SN05109869-W 20180930/180928230702-6f66a46fa02ae24ebf767a72ef524065 (fbodaily.com)
- Source
-
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