SPECIAL NOTICE
A -- Blast Exposure Model for Career Artillery Personnel Exposed to Repetitive Low-Intensity Blast
- Notice Date
- 1/29/2020 8:52:28 AM
- Notice Type
- Special Notice
- NAICS
- 541715
— Research and Development in the Physical, Engineering, and Life Sciences (except Nanotechnology and Biotechnology)
- Contracting Office
- W4PZ USA MED RSCH ACQUIS ACT FORT DETRICK MD 21702-5014 USA
- ZIP Code
- 21702-5014
- Solicitation Number
- MTEC-20-04-Blast-Model
- Response Due
- 2/28/2020 9:00:00 AM
- Archive Date
- 03/14/2020
- Point of Contact
- Randall Fernanders, Phone: 8437603378
- E-Mail Address
-
randall.fernanders@ati.org
(randall.fernanders@ati.org)
- Description
- The Medical Technology Enterprise Consortium (MTEC) is excited to post this announcement for a Request for Project Proposals (RPP) focused on the development of a model for potential brain and systemic physiological changes that occur after repetitive exposure to low-intensity blast overpressure events in experienced military artillery personnel. Program Description: Blast overpressure dynamics emanating from military artillery pieces is unique from other military weapon systems that may have the potential to exhibit long-term neurological effects. This upcoming RPP will request proposal submissions that describe projects focused on the development of a prototype model system for repetitive blast exposure for artillery weaponry. The Government is seeking a model to provide a tool to operators and system planners to assess potential long-term neurological effects of low-intensity blast exposure specific to military artillery communities. The model shall also enable the assessment of relationships between the numbers of repetitive low-intensity blast exposure from artillery weapons with specific neurological outcome measures. Solution Requirements: Previous studies show converging evidence of model systems for neurophysiological effects from cumulative exposure to repetitive blasts in breacher populations. This prototype effort is intended to expand these findings by examining a cohort of experienced artillery personnel who may incur cumulative effects of repeated low-level blast exposure associated with military artillery weaponry. Proposed projects shall 1) conduct a human study to determine the neurophysiological effects of repetitive low-level exposure to overpressure associated with artillery weaponry, and 2) use these data sets to develop a model for potential brain and systemic physiological changes that occur after repetitive exposure to low-intensity blast overpressure events. The Offeror shall: - Establish a multi-institutional regulatory framework for a human subject�s research protocol to permit the assessment of 30 experienced career artillery service members and 30 matched controls recruited from operational units. Submit an approved institutional human subject�s protocol for second level DoD review and approval by the USAMRDC Human Research Protection Office (HRPO). - Conduct comprehensive neurological assessments of military operational participants recruited from operational units. Assessments shall include a participant history utilizing a demographic and head injury questionnaire,� neuropsychological testing tests of memory, attention, and general cognitive function, neuroimaging utilizing magnetic resonance imaging (MRI) and shall include T1 and T2-weighted imaging, fluid attenuation inversion recovery (FLAIR) imaging, susceptibility weighted imaging (SWI), diffusion tensor imaging (DTI), perfusion weighted imaging, functional connectivity, and task-based functional MRI, assessment of fluid biomarkers, and tests of� postural/stability, auditory, and vestibular function in a total of 30 experienced career artillery service members and well-matched controls will be recruited from operational units. - Apply state-of-the-art feature engineering/extraction approaches to structure data across the datasets to generate a model for potential brain and systemic physiological changes that occur after repetitive exposure to low-intensity blast overpressure events in career experienced military artillery personnel. Using complex analytical techniques the investigators will test the hypothesis that participation in artillery service member activity results in structural, functional, and physiological neurological alterations compared to controls. The primary outcome deliverable will be a model for potential brain and systemic physiological changes that occur after repetitive exposure to low-intensity blast overpressure events in career experienced military artillery personnel. Potential Funding Availability: The U.S. DoD anticipates the total project funding for the three (3) year effort to be $2.1 Million Defense Health Program (DHP) Research, Development, Test, and Evaluation (RDT&E) funds. Award funding is expected to be structured incrementally and based upon completion of Milestones and Deliverables. The Period of Performance (POP) is not to exceed three years. It is expected that MTEC will make one award to a qualified team to accomplish all tasks. If a single proposal is unable to sufficiently address the entire scope of the RPP, several Offerors may be asked to work together in a collaborative manner. However, if an optimal team is not identified, then MTEC may make multiple, individual awards to Offeror(s) to accomplish subset(s) of the key tasks. Acquisition Approach: Full proposals are due no later than February 28, 2020 at 12:00pm Eastern Time. The RPP will be posted to the MTEC website (mtec-sc.org) and a notice will be posted on www.beta.SAM.gov to notify interested parties. MTEC membership is required for the submission of a full proposal in response to this MTEC RPP. Offerors submitting Full Proposals as the prime contractor must be MTEC members of good standing by February 25, 2020.� To join MTEC, please visit http://mtec-sc.org/how-to-join/ A Proposers Conference via webinar will be held for interested parties to have their questions answered by the USG after the RPP is posted.� MTEC Members will be notified when the Proposers Conference is scheduled. MTEC: The MTEC mission is to assist the U.S. Army Medical Research and Development Command (USAMRDC) by providing cutting-edge technologies and supporting life cycle management to transition medical solutions to industry that protect, treat, and optimize Warfighters� health and performance across the full spectrum of military operations. MTEC is a biomedical technology consortium collaborating with multiple government agencies under a 10-year renewable Other Transaction Agreement (OTA), Agreement No. W81XWH-15-9-0001, with the U.S. Army Medical Research Acquisition Activity (USAMRAA). MTEC is currently recruiting a broad and diverse membership that includes representatives from large businesses, small businesses, �nontraditional� defense contractors, academic research institutions and not-for-profit organizations. Points of Contact: Please direct your inquiries and correspondence to the following contacts: - Questions concerning contractual, cost or pricing related to this RPP should be directed to the MTEC Contracts Administrator at mtec-contracts@ati.org. - Technical and membership questions � Dr. Lauren Palestrini, MTEC Director of Research, lauren.palestrini@officer.mtec-sc.org. - Programmatic questions � Ms. Kathy Zolman, MTEC Director of Program Operations, kathy.zolman@ati.org. - MTEC Member Collaboration Database Tool � Ms. Melissa Sanchez, MTEC Program Administrator, Melissa.sanchez@ati.org.
- Web Link
-
SAM.gov Permalink
(https://beta.sam.gov/opp/684617677ca6448ea249a6d07985dd30/view)
- Place of Performance
- Address: Frederick, MD 21702, USA
- Zip Code: 21702
- Country: USA
- Zip Code: 21702
- Record
- SN05546141-F 20200131/200129230140 (samdaily.us)
- Source
-
SAM.gov Link to This Notice
(may not be valid after Archive Date)
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