SOURCES SOUGHT
66 -- Cell Vivo BioArray Matrix (BAM) Instrument and Disposables
- Notice Date
- 5/21/2020 4:51:51 PM
- Notice Type
- Sources Sought
- NAICS
- 334516
— Analytical Laboratory Instrument Manufacturing
- Contracting Office
- NATIONAL INSTITUTES OF HEALTH NIDA Bethesda MD 20892 USA
- ZIP Code
- 20892
- Solicitation Number
- HHS-NIH-NIDA-SB-SS-20-006747
- Response Due
- 6/1/2020 9:00:00 AM
- Archive Date
- 09/30/2020
- Point of Contact
- Debra C. Hawkins, Phone: 3018277751
- E-Mail Address
-
Debra.Hawkins@nih.gov
(Debra.Hawkins@nih.gov)
- Description
- Description: This is a Small Business Sources Sought notice. This is NOT a solicitation for proposals, proposal abstracts, or quotations. The purpose of this notice is to obtain information regarding: (1) the availability and capability of qualified small business sources; (2) whether they are small businesses; HUBZone small businesses; service-disabled, veteran-owned small businesses; 8(a) small businesses; veteran-owned small businesses; woman-owned small businesses; or small disadvantaged businesses; and (3) their size classification relative to the North American Industry Classification System (NAICS) code for the proposed acquisition. Your responses to the information requested will assist the Government in determining the appropriate acquisition method, including whether a set-aside is possible. An organization that is not considered a small business under the applicable NAICS code should not submit a response to this notice. This notice is issued to help determine the availability of qualified companies technically capable of meeting the Government requirement and to determine the method of acquisition.� It is not to be construed as a commitment by the Government to issue a solicitation or ultimately award a contract.� Responses will not be considered as proposals or quotes.� No award will be made because of this notice.� The Government will NOT be responsible for any costs incurred by the respondents to this notice.� This notice is strictly for research and information purposes only. Background Information and Objective:� This system is required to effectively cultivate on a large scale, human 3D organoids from taste, liver and intestinal adult stem cells and brain organoids from iPSCs to address a number scientific questions which we have in LCI in more clinically relevant human organoid models. Currently we are using an in-house produced bioreactor which is time consuming and costly to produce and does not allow us to produce organoids on as a large scale as this technology does. This is a huge limitation on our studies and on the number and types of organoids we currently can study within our lab.� Use of this technology would allow the researchers to address questions on cannabinoid 1 receptor antagonism in human liver organoids, questions as to the role of DPP-IV inhibition in FGF19 production in human intestinal organoids and questions of the effect of aging in human taste organoids. Thus, this system can be used in several projects.� The specific advantages of this system are that it is more compatible with how human tissues behave in vivo- by using a unidirectional gravity system that is thus mechanically easier on the organoids formed and can sustain them in culture for longer. The CelVivo system creates an environment which promotes the growth and maintenance of large 3D tissue mimetic structures, whether they are spheroids, organoids, acini and other aggregates. In this environment, organoids remain in a stable dynamic equilibrium and exhibit human in vivo physiological performance for at least 24 days (i.e. up to at least 42 days of culture). During this time the spheroids exhibit a stable transcriptome profile. The intent of this action is to purchase a Cell Vivo BioArray Matrix (BAM) Instrument and Disposables that is the brand-name or equal to the Cell Vivo Bio Array Matrix instrument manufactured by� CelVivo ApS, Middelfartvej 469, DK-5491 Blommenslyst, Denmark.� The instrument includes: (1) Part number: CV100201 BioArray Matrix Drive (BAM), 110-230V. Includes: (a) 16 axel motor drive unit, powered by cooling unit; and (b) Cooling and Control unit, Control Tablet with pre- Installed software, Cables, Hoses, Instruction Manuals. Model 4. P/N 100201; (2) Part number: CV200050; Description: Bioreactor DM-10, Box of 50, 10 ml, individually wrapped, sterile. Bioreactors (disposables): P/N 200001 (qty 1), P/N 200005 (qty 5), P/N 200050 (qty 50), P/N 2000100 (qty 100); (3) Part number: 900920 Shipping; and (3) Part number: CV300100 Five (5) day On-site Training Course for up to four (4) people. The five days must be contiguous. Includes all travel costs.� All hardware, software, and disposables are warranted for 2 years from date-of-delivery.� Additional quantities of bioreactors (disposable). Extended Service Agreements, which include unlimited phone and email support (P/N 400100). Extended Service Agreement plus Annual Preventative Maintenance on-site visit (P/N 400150). Salient characteristics: (a) The system allows for flexible and rapid purification of proteins and peptides in the microgram to gram range; (b) The system allows for the culturing of cells to yield cell culture in the form of spheroids or organoids and to incubate and grow uniform spheroids under perfect conditions for time periods of up to one year; (c) The system allows for the culturing of cells under low shear force conditions; (d) Bioreactor vessels equipped with a humidification labyrinth allowing the use in a non-humidified incubator, highly reducing the risk of infection; (e) Capability of 3D cultivation of cell culture; (f) The system has the capability to take multiple samples makes spheroids attractive for drug testing, recovery studies and combination therapies; (g) Capability to control rotation speed of each vessel can be precisely controlled via a microcomputer; and (h) User friendly software which allows for data logging and control via tablet. Anticipated period of performance / delivery date:� The Government�s anticipated delivery period is thirty (30) days after receipt of order. ��� Other important considerations: The response may cite any other information that is necessary for potential respondents to understand the nature of the potential requirement or proposed acquisition. Capability statement /information sought.� The respondents must submit clear and convincing evidence that their product is equivalent or superior to the brand-name product specified in this notice.� The response shall include: the unit price, list price, shipping and handling costs, delivery days after contract award, delivery terms, prompt payment discount terms, F.O.B. Point (Destination or Origin), product or catalog number(s); product description; and any other information or factors that may be considered to determine the method of acquisition.� The information must address each of the minimum specifications and the equivalent elements of the brand-name parts stated herein.� The response must also indicate the country of manufacturer. The response must also include their DUNS number, organization name, address, point of contact, and size and type of business (e.g., 8(a), HubZone, etc., pursuant to the applicable NAICS code and any other information that may be helpful in developing or finalizing the acquisition requirements. The response must include the respondents� technical and administrative points of contact, including names, titles, addresses, telephone and fax numbers, and e-mail addresses. The response must be clear and concise in Microsoft Word or Adobe PDF format using 11-point or 12-point font, 8-1/2� x 11� paper size, with 1� top, bottom, left and right margins, with single or double spacing, and limited to ten (10) pages (exclusive of the cover page, executive summary, or references, if requested). All responses to this notice must be submitted electronically to Debra C. Hawkins Contractor, Acquisition Policy Analyst II, at debra.hawkins@nih.gov on or before June 1, 2020, 12:00 PM.� Facsimile responses are NOT accepted. Disclaimer and Important Notes:� This notice does not obligate the Government to award a contract or otherwise pay for the information provided in response. The Government reserves the right to use information provided by respondents for any purpose deemed necessary and legally appropriate. Any organization responding to this notice should ensure that its response is complete and sufficiently detailed to allow the Government to determine the organization�s qualifications to provide the product or perform the services specified herein. Respondents are advised that the Government is under no obligation to acknowledge receipt of the information received or provide feedback to respondents with respect to any information submitted. After a review of the responses received, a presolicitation synopsis and solicitation may be published in Federal Business Opportunities. However, responses to this notice will not be considered adequate responses to a solicitation. Confidentiality: No proprietary, classified, confidential, or sensitive information should be included in your response. The Government reserves the right to use any non-proprietary technical information in any resultant solicitation(s).�
- Web Link
-
SAM.gov Permalink
(https://beta.sam.gov/opp/99b8c97c261c4b738f6cb3db7d0c68ba/view)
- Place of Performance
- Address: Baltimore, MD 21224, USA
- Zip Code: 21224
- Country: USA
- Zip Code: 21224
- Record
- SN05668447-F 20200523/200521230232 (samdaily.us)
- Source
-
SAM.gov Link to This Notice
(may not be valid after Archive Date)
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