Loren Data's SAM Daily™

SAMDAILY.US - ISSUE OF SEPTEMBER 18, 2020 SAM #6868
SOLICITATION NOTICE

A -- Spironolactone as a novel pharmacotherapy for alcohol use disorder

Notice Date

9/16/2020 7:25:28 AM
 

Notice Type

Presolicitation
 

NAICS

541715 — Research and Development in the Physical, Engineering, and Life Sciences (except Nanotechnology and Biotechnology)
 

Contracting Office

NATIONAL INSTITUTES OF HEALTH NIDA Bethesda MD 20892 USA
 

ZIP Code

20892
 

Solicitation Number

75N95020Q00334
 

Response Due

9/21/2020 9:00:00 AM
 

Archive Date

10/06/2020
 

Point of Contact

Kenneth Goodling, Phone: 3014436677, Kenneth Goodling, Phone: 3014436677
 

E-Mail Address

kenneth.goodling@nih.gov, kenneth.goodling@nih.gov
(kenneth.goodling@nih.gov, kenneth.goodling@nih.gov)
 

Description

The objective of the proposed project is to investigate the impact of spironolactone on alcohol consumption in a general patient population.�Using data from the Veteran Birth Cohort, a long-term and large-scale cohort study, we will investigate the association between spironolactone use (prescribed for any indication) and alcohol consumption in adults. Spironolactone-exposed individuals will be propensity-score matched to up to five unexposed individuals. Multivariable linear regression models will estimate changes in Alcohol Use Disorders Identification Test - Consumption (AUDIT-C) scores before and after spironolactone exposure. Results will provide information on the possible early efficacy signal with this drug, building the foundation for prospective randomized clinical trials. Please see attached Notice of Intent
 

Web Link

SAM.gov Permalink
(https://beta.sam.gov/opp/e0b43dd876a447c1b01f6cddab1eff1b/view)
 

Place of Performance

Address: Baltimore, MD 21224, USA

Zip Code: 21224

Country: USA
 

Record

SN05799324-F 20200918/200916230158 (samdaily.us)
 

Source

SAM.gov Link to This Notice
(may not be valid after Archive Date)

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