SPECIAL NOTICE
A -- Human Multi-Organ Tissue Equivalent Platform
- Notice Date
- 1/26/2022 1:36:06 PM
- Notice Type
- Special Notice
- NAICS
- 541714
— Research and Development in Biotechnology (except Nanobiotechnology)
- Contracting Office
- W4PZ USA MED RSCH ACQUIS ACT FORT DETRICK MD 21702-5014 USA
- ZIP Code
- 21702-5014
- Solicitation Number
- Panmra-22-P-0000-001464
- Response Due
- 2/11/2022 7:00:00 AM
- Archive Date
- 02/12/2022
- Point of Contact
- Deborah Hagan
- E-Mail Address
-
deborah.l.hagan.civ@mail.mil
(deborah.l.hagan.civ@mail.mil)
- Description
- The scope of effort will encompass the task of protecting the warfighter from a natural or manmade attack and have the ability to rapidly identify the best methods available to maintain mission critical status. The Contractor will conduct all activities in compliance with FDA CVM regulations, current Good Manufacturing Processes (cGMP), and other applicable regulations as necessary. The Government seeks an Organ Tissue Equivalent (OTE) platform, which utilizes cutting edge 3D organ-on-a-chip technologies and offers one such solution for the military by providing a tool for rapidly identifying medical countermeasures for the prevention and treatment of emerging viral diseases. The lung OTE shall be comprised entirely of human cells including the epithelial, endothelial, stromal, and inflammatory components of native lung tissue. Unlike typical 2D systems, these constructs shall be arranged in a pseudostratified architecture and produce mucus and surfactant providing a physiologically relevant model system. The overarching goal of the proposed studies is to validate the human lung construct as a The scope of effort will encompass the task of protecting the warfighter from a natural or manmade attack and have the ability to rapidly identify the best methods available to maintain mission critical status. The Contractor will conduct all activities in compliance with FDA CVM regulations, current Good Manufacturing Processes (cGMP), and other applicable regulations as necessary. The Government seeks an Organ Tissue Equivalent (OTE) platform, which utilizes cutting edge 3D organ-on-a-chip technologies and offers one such solution for the military by providing a tool for rapidly identifying medical countermeasures for the prevention and treatment of emerging viral diseases. The lung OTE shall be comprised entirely of human cells including the epithelial, endothelial, stromal, and inflammatory components of native lung tissue. Unlike typical 2D systems, these constructs shall be arranged in a pseudostratified architecture and produce mucus and surfactant providing a physiologically relevant model system. The overarching goal of the proposed studies is to validate the human lung construct as a�flexible model for viral pulmonary infections and the resultant inflammatory response. The system will also be used to test the efficacy of potential medical countermeasures, and for identifying potential downstream disease target organs. Using 3 highly relevant respiratory viruses, SARS-CoV-2, MERS and pandemic H1N1 influenza.
- Web Link
-
SAM.gov Permalink
(https://sam.gov/opp/9a27e6b4315d450fa5b0461766607c59/view)
- Place of Performance
- Address: Frederick, MD, USA
- Country: USA
- Country: USA
- Record
- SN06224893-F 20220128/220126230103 (samdaily.us)
- Source
-
SAM.gov Link to This Notice
(may not be valid after Archive Date)
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