Loren Data's SAM Daily™

SAMDAILY.US - ISSUE OF NOVEMBER 17, 2024 SAM #8391
SOLICITATION NOTICE

Q -- Transcriptomics Sequencing and analysis in Liver Spheroids

Notice Date

11/15/2024 6:48:37 AM
 

Notice Type

Combined Synopsis/Solicitation
 

NAICS

325414 — Biological Product (except Diagnostic) Manufacturing
 

Contracting Office

NATIONAL INSTITUTES OF HEALTH NIDA Bethesda MD 20892 USA
 

ZIP Code

20892
 

Solicitation Number

75N95025Q00040
 

Response Due

11/22/2024 12:00:00 PM
 

Archive Date

11/23/2024
 

Point of Contact

Chandani Hangilipola, Phone: 13014807089
 

E-Mail Address

chandani.hangilipola@nih.gov
(chandani.hangilipola@nih.gov)
 

Description

The National Center for Advancing Translational Sciences (NCATS) requires transcriptomics sequencing and analysis in liver spheroids. This requisition is requesting a contract to evaluate the RNA expression in liver toxicity associated with the systemic administration of antisense oligonucleotides (ASOs) in previously tested human, rat and mouse animal models. The project's phase one goal is to develop a predictive model of candidate ASO therapies' safety and acute toxicity. NCATS is seeking technical support to evaluate the safety and acute liver toxicity of candidate ASOs by checking the gene expression. The results from these studies, in conjunction with existing cell-based assays, will help better predict the safety of future candidate ASOs intended for clinical use. The objective of this contract is to generate proof-of-concept data for evaluating the ability of the 3D liver microtissue platform to predict the hepatoxicity of individual ASOs. If successful, this will represent a new means to screen ASOs for this type of toxicity that is cheaper, faster, and has high throughput. NCATS is seeking technical support to evaluate the safety and acute liver toxicity of candidate ASOs by checking the gene expression. The results from these studies, in conjunction with existing cell-based assays, will help better predict the safety of future candidate ASOs intended for clinical use.
 

Web Link

SAM.gov Permalink
(https://sam.gov/opp/744ddc5e79274223ad51517e767ff410/view)
 

Place of Performance

Address: Rockville, MD 20850, USA

Zip Code: 20850

Country: USA
 

Record

SN07266378-F 20241117/241115230102 (samdaily.us)
 

Source

SAM.gov Link to This Notice
(may not be valid after Archive Date)

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