HSC/PKR, DCS CONTRACTING, 8005 9Th STREET, BROOKS AFB, TX 78235-5353

A -- PROFESSIONAL TOXICOLOGY RESEARCH SERVICES SOL F41624-95-R-9003 DUE 100595 POC Ms. LEE BALES, CONTRACT NEGOTIATOR, (210) 536-6397 Mr. MICHAEL FLEISCHMAN, CONTRACTING OFFICER. Toxicology Research - NOCA PKR 95-11. The Division of R&D Contracting intends to issue RFP No. F41624-95-R-9003 for professional toxicology services in support of the Toxicology Division, Armstrong Laboratory, Wright-Patterson AFB, OH, which conducts a broad spectrum of scientific research designed to quantitate safe exposure levels for chemicals. The successful offeror will be teaming with the Army, Navy, and Air Force (tri- service) to design and perform research to assess pharmacokinetics, local and systemic effects, and mechanisms of toxicity for chemicals chosen by the tri-service. Acquiring information about the deleterious interaction of chemicals with living organisms requires a step-wise application of specific scientific processes to gather data. The information obtained is used either to answer the questions posed or to design the experiments necessary to generate those answers. The research efforts will include descriptive/general toxicology, mechanistic toxicology (toxicokinetics, mechanism of action and toxicodynamics), and predictive toxicology (parameter determination, model development and model validation). Studies will range from short-term pharmacokinetic investigations to lifetime carcinogenic bioassays and will include oral, inhalation, and dermal exposures. Development and application of computer modeling techniques and alternatives, such as in vitro screening (cell culture, liver slice, etc.), will be necessary to provide an accurate and responsive chemical hazard assessment capability. Post-doctoral level experience in the areas of toxicology, pharmacology, physiology, pharmacokinetics, physiologically-based modeling, analytical chemistry, biochemistry and inhalation/aersol engineering is required to advance the state-of-the-art. Research support functions that are anticipated include safety/quality assurance, logistics, archives, fabrication, tech editing, computer system management and related technical areas to support the scientific staff in accomplishing the objectives of the research projects. A cost-reinbursement contract is contemplated for this effort with an anticipated baseline level of effort at 87,000 hrs/yr. Additional level of effort, generally short term, may be required to support unforeseen surges in project workload (up tp 27,000 hrs/yr). The period of performance is contemplated to be 60 months. A Security Clearance will not be required in performance of this work. An advance notice was published previously under R&D Sources Sought PKR 95-04 on March 8, 1995. SIC Code 8731 has been assigned. Requests for copies of the solicitation should be received in writing no later than ten days from the date of this listing . Requests should be addressed to HSC/PKRE, 8005 9th Street, Brooks AFB, TX 78235-5353, ATTN: Ms. Lee Bales. Telephone requests will not be honored. Information is required in your response as to whether your firm is considered a small business, small disadvantaged business, or woman owned business. The RFP is scheduled for release within 30 days from the date of this publication. All respondees to this synopsis shall include their assigned Commercial and Government Entity (CAGE) Code (i.e., Federal Supply Code for Mfrs., a five digit code assigned by Cmdr, Battle Creek, MI., Ref DOD 5000.12(M)). A preprosal conference, to include a site visit of the toxicology laboratory, will be conducted at Wright-Patterson AFB. The exact date, time, and building location of the prepropsal conference will be in the solicitation. All responsible sources may submit a proposal which shall be considered by the sponsoring agency. (0178)

Loren Data Corp. http://www.ld.com (SYN# 0002 19950628\A-0002.SOL)