Office of Naval Research, 800 North Quincy St., Arlington, VA 22217-5660

A -- BASIC AND APPLIED BIOMEDICAL RESEARCH IN COMBAT CASUALTY CARE POC J. Majde, ONR 341 (703) 696-4055. The Office of Naval Research and the Naval Medical Research and Development Command are jointly soliciting preproposals directed at basic and applied biomedical research focusing on Navy-relevant aspects of combat casualty care, particularly hemorrhagic shock and blood products. This notice constitutes a Broad Agency Announcement (BAA) as contemplated in FAR 6.102 (dX2). The following aspects of hemorrhagic shock research and development are of interest: (1) mechanisms and treatment of hypoxic injury at the cellular and molecular level (POC: Dr. C. Oliver (703) 696-4053), (2) neural induction or neuro/endocrine regulation of cytokines and other soluble mediators involved in hemorrhagic shock (POC: Dr. J. Majde (703) 696-4055), (3) novel therapeutic interventions for sever hemorrhage and shock (POC: Drs. Oliver or Majde), and (4) design, testing and evaluation of supportive and therapeutic resuscitation fluids (Drs. Oliver or Majde). The following aspects of blood product research and development are also of interest: (1) methods for the extension of liquid storage of red cells and platelets (POC: CDR Lyn Yaffe (301) 295-1825), (2) cryopreservation of blood products not requiring post-thaw cryoprotectant washout (POC: Lyn Yaffe), and (3) impact of blood substitutes at the molecular, cellular & organ system levels in treatment of hemorrhagic shock (POC: Drs. Oliver or Majde or CDR Yaffe). It is not the intent of this solicitation to establish new facilities, rather, institutions having demonstrated research capability and the necessary facilities are invite to submit five copies of a preproposal not exceeding three pages of text that describes: (a) the research objective, (b) the research approach, (c) related work by the proposer, (d) anticipated contributions to the Navy program, and (e) an estimate of overall costs (including indirect) for a three year effort. A curriculum vitae of the principal investigator(s) should be appended together with any supporting information, such as reprints or preprints, that will assist in the evaluation of the preproposal. Preproposals whose main objectives are to conduct analyses, literature reviews, or program evaluations are not encouraged. Preproposal submssions will be evaluated on the basis of innovativeness, scientific merit, and programmatic relevance. Full formal proposals for competitive review will be requested based on those submissions judged most likely to meet program objectives. Proposal deadline dates and format instruction will be provided at that time. The initial deadline for preproposals will be 01 February 1996. Preproposals may be submitted after 01 February 1996 for consideration in the next funding cycle. Preproposals (5 complete copies) should be sent to either: Dr. Robert W. Newburgh, Director, Biomedical Science and Technology Division (96-007), Office of Naval Research, 800 North Quincy Street, Arlington, VA 22217-5660, (703) 696-4986 or CDR Lyn Yaffe, Director, Research and Development, Naval Medical Research and Development Command, National Naval Medical Center, Bethesda, MD 20889, (301) 295-1825. For awards made as contracts the socio-economic merits will include the extent of commitment in providing meaningful subcontracting opportunities for small business, small disadvantaged business, woman-owned small business concerns, and historically black colleges and universities. This is to notify potential proposers that each grant or cooperative agreement that is awarded under this announcement or solicitation to an institution of higher education must include the following clause: ''As a condition for receipt of funds available to the Department of Defense (DoD) under this award, the recipient agrees that it is not an institution that has a policy of denying, and that it is not an institution that effectively prevents, the Secretary of Defense from obtaining for military recruiting purposes: (A) entry to campuses, or (B) access to directory information pertaining to students. If the recipient is determined, using procedures established by the Secretary of Defense to implement section 558 of Public Law 103-337 (1994), to be such an institution during the period of performance of this agreement, and therefore to be in breach of this clause, the Government will cease all payments of DoD funds under this agreement and all other DoD grants and cooperative agreements, and it may suspend or terminate such grants and agreements unilaterally for material failure to comply with the terms and conditions of award.'' If your institution has been identified under the procedures established by the Secretary of Defense to implementsection 558, then: (1) no funds available to DoD may be provided to your institution through any grant, including any existing grant, (2) as a matter of policy, this restriction also applies to any cooperative agreement, and (3) your institution is not eligible to receive a grant or cooperative agreement in response to this solicitation. (0361)

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