Lawrence Livermore National Laboratory, 7000 East Avenue, Livermore, CA 94550

A -- LAWRENCE LIVERMORE NATIONAL LABORATORY SEEKS PARTNERSHIPS WITH INDUSTRY TO COMMERCIALIZE HYDROXYAPATITE SYNTHESIS TECHNOLOGY POC For further information, contact Industrial Partnerships & Commercialization, at (510) 423-3139. Announcement - The Lawrence Livermore National Laboratory (LLNL), operated by the University of California under contract with the U.S. Department of Energy (DOE), is seeking U.S. companies interested in licensing or participating in a cooperative research and development agreement to commercialize LLNL technology for the synthesis of hydroxyapatite powder of controlled size and structure as a biological chromatography support for protein purification and DNA isolation. We have developed a process to produce granules of various morphologies, including hollow or solid spheres and donut-shaped hydroxyapatite, of uniform size ranging from 1 to 8 microns. Smaller and more consistent granule sizes have several advantages over conventional hydroxyapatite powders, including 1) higher specific surface area and bonding capacity; 2) improved mechanical properties of the column resulting from more contacting surface areas and greater frictional forces between granules; and 3) a more homogeneous pore distribution resulting from the packing of uniform particles. The partnerships will be coordinated through Industrial Partnerships and Commercialization at LLNL. Moving critical technology beyond the Laboratory to the commercial world helps our U.S. licensees gain a competitive edge in the marketplace. The University of California's Lawrence Livermore National Laboratory can license technology through exclusive or non-exclusive licensing agreements, as appropriate. Cooperative research and development agreements (CRADAs) are structured to offer partner companies the opportunity to license LLNL technologies at the end of the project. All projects are conducted under policies relating to the strict nondisclosure of company proprietary information. NOTE: THIS IS NOT A PROCUREMENT. If you are interested in working with LLNL on commercializing this hydroxyapatite synthesis technology, please respond in writing within 45 days of this announcement by providing a short background description of your company and your specific interest and capability. (127)

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