National Cancer Institute, Research Contracts Branch, CECS, 6120 Executive Blvd, EPS/Room 620, Bethesda, MD 20892-7224

A -- RESOURCE FOR COLLECTION AND EVALUATION OF HUMAN TISSUE AND CELLS FROM DONORS WITH EPIDEMIOLOGY PROFILES SOL RFP N01-BC-71006-21 DUE 102496 POC Barbara A. Shadrick, Contracting Officer, Phone 301/496-8611, Fax 301-480-0241, E-mail SHADRICB@RCB.NCI.NIH.GOV. The Laboratory of Human Carcinogenesis (LHC), Division of Basic Sciences (DBS), National Cancer Institute (NCI), National Institutes of Health (NIH), is recompeting a four-year tissue- collection contract. Proposals are now being solicited from qualified firms to provide the necessary resources for the collection of viable surgical, biopsy and autopsy specimens from a variety of human tissues and cells (lung, bronchus, colon, liver, pancreas) and other biological specimens (pleural effusions, blood and urine) from donors with epidemiological profiles prepared in specifically designed patient questionnaires which include the relevant medical records. The incumbent contractor is The University of Maryland at Baltimore (Contract N01-BC-33010), which is scheduled to expire March 30, 1997. The LHC subjects the tissues and cells to in vitro adaptability and carcinogenesis, biochemical characterizations and assays of chemical and oncogene-induced alterations of macromolecules, innovative methods for determining populations at risk for certain carcinogens by biochemical epidemiology survey. Relevant studies are extenuated by the application of xenotransplantation techniques for definitive assay of chemically stimulated tumorigenesis. It is anticipated that the RFP NIH-NCI-N01-BC- 71006-21 will be available electronically on or about September 9, 1996, and may be accessed through either the NIH Gopher or the NIH Home Page by using the following electronic mail addresses and instructions: 1) The NIH Gopher address is GOPHER.NIH.GOV PORT 70. Select Grant & Research Information then select R&D Requests for Proposals (RFP), 2) NIH Home Page (via World Wide Web) can be accessed by using http://www.nih.gov, select Grants & Contracts, then select R&D Requests for Proposals (RFP). Please note that the RFP for this acquisition has been revised to include only the Work Statement, deliverables and reporting requirements, special requirements and mandatory qualifications (if any), Technical Evaluation Criteria and proposal preparation instructions. All information required for the submission of an offer will be contained in the electronic RFP package. If your organization cannot access this RFP through electronic means, you may request a copy in writing (via mail or fax) to the Contracting Officer at the address provided with this announcement. Proposals shall be due 45 days following the actual date of RFP issuance. The NCI shall consider proposals from all responsible sources. However, offerors must demonstrate, in their technical proposal, their ability to facilitate delivery of the nonfrozen viable tissues to the NCI in Bethesda, Maryland within two hours of collection as a mandatory qualification criteria of this solicitation. Failure to demonstrate this element at the time of original submission will result in the offerors elimination from further consideration. This contract will be awarded as a multiple-year, cost- reimbursement, level-of-effort (term) type contract with a required level-of-effort for all four years of 50,284 person hours (an estimated 12,571 hours per year) and incremental funding will be used. Collect calls will not be accepted (0234)

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