National Institute of Environmental Health Sciences, P.O. Box 12874, Research Triangle Park, North Carolina 27709

A -- GENERATION OF KNOCK-OUT MICE SOL DL00347 DUE 040397 POC Contact Point, Dee Lunney, Contracting Officer, 919-541-0387 The National Institute of Environmental Health Sciences intends to procure generation of knock-out mice. This work shall use the method of homologous recombination to disrupt specific genes in embryonic stem (ES) cells, and inject such ES cells into mouse blastocysts to produce chimeric mice carrying the disrupted gene. Requests for a solicitation package shall be directed to Dee Lunney, NIEHS, P.O.Box 12874, Research Triangle Park, NC 27709, and reference DL00347. Requests for solicitation package must be in writing or by fax (919) 541-5117 and must be received no later than 4/8/97. No telephone requests for solicitation package will be accepted. (0077)

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