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A -- LOW-COST, HIGH-ACCURACY DNA SEQUENCING TECHNOLOGIES SOL RFA: HG-97-002 DUE 101697 POC Jeffery A. Schloss, Program Director, 301-496-7531 The National Human Genome Research Institute, NIH, issued a Request for Applications for research on next-generation technologies that have the potential to reduce the cost of high-accuracy genomic DNA sequencing by at least an order of magnitude. State-of-the-art technology can currently generate sequence data containing less than 1 error per 10,000 base pairs at a total cost (including machines, personnel, supplies, and overhead) of approximaely $0.50 per base pair. The goal of research resulting from this RFA will be to drive this total cost of obtaining accurate (<1 error in 10,000 bp) sequence to well below $0,05 per base pair. The RFA was published in the NIH Guide for Grants and Contracts, vol. 26, no. 16, May 16, 1997. The research will be supported by various grant mechanisms. Prospective applicants are asked to submit, by August 1, 1997, a letter of intent. The web site for this RFA is located at http://www.nhgri.nih.gov./Grant_info/Funding/rfa-hg-97-002.html. The publication of this notice and/or the issuance of an RFA does not obligate the U.S. Government to make an award. (0183)

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