U.S. Environmental Protection Agency, 26 W. Martin Luther King Dr., Cincinnati, OH 45268

A -- QSAR ANALYSIS AND INTERPRETATION OF DBP CHEMICALS SOL PROBCOK-3KBPEL DUE 082797 POC Hans Schellhas (513) 366-2055 WEB: Office of Acquisition Management -- Cincinnati Contracts Management Division, Not Applicable. E-MAIL: U.S. EPA -- Cincinnati Contracts Mangement Division, schellhas.hans@epamail.epa.gov. The U.S. Environmental Protection Agency plans to procure on a sole source basis with Health Designs, Inc. an acquisition to do Quantitative Structure-Activity Relationship (QSAR) Analysis and Interpretation of Disinfection By-Products (DBP) Chemicals. This effort will involve the QSAR/TOPKAT analysis of 50 organic chemicals, the majority of which are DBPs. The chemicals will be analyzed for various health-related and/or physicochemical properties using these QSAR/TOPKAT submodels: [Carcinogenicity (rat/mouse/female/male), Ames mutagenicity, Developmental Toxicity, skin sensitization, LOAEL, LD50, LC50, and Log P]. The analysis of all 50 chemicals will include the generation of predictions (based on E-state fragments and values) and structure similarity searches for all toxic endpoints cited above. Individual reports of the analyses will be prepared for each of the 50 chemicals and compiled by chemical class. An overall assessment in the form of a final report will be prepared summarizing all the data for the 50 chemicals regarding toxicity predictions, E-state fragments and values and similarity searches. In addition, all of these data will be correlated for trends with respect to toxicity based on predictions, E-state fragments and values within and across homologous classes of compounds and/or functional groups. The basis for sole source negotiations is that the TOPKAT/QSAR models are provided only in the software developed by the company and are protected by exclusive licensing agreements. THIS IS NOT A REQUEST FOR PROPOSALS. Sources wishing to be considered must submit documentation to the office identified above, which establishes the ability to perform the subject work under the exclusive licensing agreement . Documentation must be submitted within 15 calendar days of publication of this notice. (0219)

Loren Data Corp. http://www.ld.com (SYN# 0005 19970811\A-0005.SOL)