National Cancer Institute, Research Contracts Branch, PSCS, 6120 Executive Blvd, Eps/room 638, Bethesda, MD 20892-7227

66 -- INSTRUMENTS & LABORATORY EQUIPMENT SOL NCI-RFQ-70174(NQ) DUE 091097 POC Cynthia Brown, Purchasing Agent, 301-402-4509 The National Inst. of Health, National Cancer Inst., intends to procure from Applied Imaging, Route 60, Robinson Plaza III, Ste. #140, Pittsburgh, Pa. 15205; one(1)- CytoVision Ultra Fish Imaging and Automated Karyotyping Workstation with a 12 Position Excitation Filter Wheel and Comprehensive Filter Set; Rewritable Optical Disc Drive for Case Archival; One Full Color Dye Sublimation Printer & One Plain Paper Laser Printer; On-Site Installation and Full User Training, The results of cytogenetics testing are used for diagnosis and treatment of patients, and to help elucidate the DNA lesions involved in both the initiation and progression of cancer. The CytoVision system will be used to perform three critical functions: First, the "gold standared" in cytogenetics has been, and continues to be, high-resolution G-banded karyotype analysis. Second; recent developments in fluorescence in-situ hybridization(FISH) technology have made it possible to "see" submicroscopic chromosomal changes in both actively-dividing (mitotic) and resting (inerphase) cells and thus FISH technology is now a standard component of state-of-the-art molecular cytogenetics laboratories.Third, comparative genomic hybridization (CGH), which also used FISH techniques, has very recently emerged as a powerful technology for investigating gains and losses of chromosomal material throughout the genome in tissue that has been fixed and/or stored. It is the Government's belief that the Cyto Vision system provides the highest resolution G-Banded Karyotypes. The CytoVision is also PC, raither than MAC based, allowing for interfacing with other laboratory systems which are PC based. This is not a request for quotes. Vendors who believe they can meet the Governments requirement may submit their qualifications/descriptive literature in writing and must contain sufficient detail so that a determination can be made regarding meeting the Governments requirements. The submission must be received by the COB 09/10/97. No collect calls will be accepted. (0233)

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