National Institutes of Health, National Institute of Allergy and Infectious Diseases, Contract Management Branch, Solar Bldg., Room 3C07, 6003 Executive Blvd. MSC 7610, Bethesda, MD 20892-7610

A -- CANDIDATE HIV VACCINE FOR CLINICAL TRIALS DUE 091097 POC Haynes Sheppard, Ph.D., FAX: (510) 540-2127, E-Mail: hsheppar@hivnet.fhcrc.org CANDIDATE HIV VACCINE FOR CLINICAL TRIALS The HIV Vaccine Efficacy Trials Network (HIVNET), through its Central Laboratory, Public Health Foundation Enterprises, located in Berkeley, California, is conducting a market survey to determine the availability and capability of developers of candidate plasmid DNA HIV vaccines for products to be used in clinical testing in humans. These products will be considered for Phase I clinical trials and may eventually be considered for larger-scale clinical trials. The HIVNET is a research consortium funded by the National Institute of Allergy and Infectious Diseases, focusing on clinical trials of HIV prevention strategies in the U.S. and in developing countries. The HIVNET Central Laboratory is responsible for coordinating laboratory aspects of prevention research and has the capacity to procure candidate HIV vaccines for human trials. To be considered, developers must have: (1) previously developed candidate plasmid DNA vaccines for use in human trials; (2) existing relationship with (or be) a manufacturer with experience in producing candidate plasmid DNA vaccines meeting FDA standards for use in human studies; and (3) experience with plasmid DNA HIV vaccine constructs. Interested firms must document their past experience and technical expertise in each of the above areas. Selected developer(s) will be asked to develop candidate plasmid DNA HIV vaccines for safety and immunogenicity testing, with a focus on vaccines for HIV subtypes other than clade B. This is not a Request for Proposal(RFP). NO RFP is available and Public Health Foundation Enterprises is not committed to award a subcontract pursuant to this announcement. Interested firms should furnish 5 copies of their capability information addressing the three(3) areas cited above, no later than 4:30 p.m. local time on September 10, 1997 to Haynes Sheppard, Ph.D., VRDL, 2151 Berkeley Way, Berkeley, CA 94704, FAX: (510) 540-2127, E-Mail: hsheppar@hivnet.fhcrc.org. (0234)

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