National Cancer Institute, Research Contracts Branch, PCPSS, 6120 Executive Blvd, Room 635, Bethesda, MD 20892-7226

A -- PROSTATE, LUNG, COLORECTAL AND OVARIAN (PLCO) CANCER SCREENING TRIAL EXPANSION SOL RFP No. N01-CN-85027-57 DUE 050898 POC Desiree E. Sylver-Foust, Contract Specialist, 301-435-3833 WEB: N01-CN-85027-57 Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial Expansion, http://rcb.nci.nih.gov/RFP.HTM. E-MAIL: Desiree E. Sylver-Foust, ds154o@nih.gov. The National Cancer Institute (NCI), Division of Cancer Prevention, Early Detection Branch, is expanding the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial and is interested in soliciting proposals from organizations for two new screening centers, each focusing on a different population group and each recruiting no less than 5,000 participants (2,500 subjects and 2,500 controls) to the Trial. One screening center will target Hispanic communities and recruit at least 1,500 Hispanic Americans (or 30 percent of their total enrollment goal) and the other will target the general U.S. population. Female subjects will be screened for colorectal, lung, and ovarian cancers. Male subjects will be screened for colorectal, lung, and prostate cancer. Following the initial screen, screening will be performed annually for three years for prostate, lung, and ovarian cancers and only at the initial and third annual screen for colorectal cancer. Subjects and controls will be followed for at least ten years. The PLCO Cancer Screening Trial was established in 1992 with ten screening centers, a Coordinating and Data Management Center, a Steering Committee, and a Monitoring and Advisory Panel. During its 2-year pilot phase protocols and biomedical data management procedures were established. The solicitation is scheduled for electronic release approximately March 19, 1998. The proposal due date will be approximately May 8, 1998. The RFP may be accessed through the Research Contracts Branch Home Page by using the following internet address: http://rcb.nci.nih.gov/RFP.HTM. It is the offerors responsibility to monitor the above Internet site for the release of this solicitation and amendments, if any. POTENTIAL OFFERORS WILL BE RESPONSIBLE FOR DOWNLOADING THEIR OWN COPY OF THE SOLICITATION AND AMENDMENTS. Point of contact: Desiree E. Sylver-Foust, Contract Specialist; FAX: 301-402-8579; Phone: 301-435-3833; Electronic Mail Address; ds154o@nih.gov. All responsible sources may submit a proposal, which shall beconsidered by the agency. No collect calls will be accepted. See numbered Note 26. (0058)

Loren Data Corp. http://www.ld.com (SYN# 0013 19980303\A-0013.SOL)