National Institute of Mental Health, Contracts Management Branch, 5600 Fishers Lane, Rm. 9C-15, Rockville, MD, 20857-8030

A -- NIMH CHEMICAL SYNTHESIS PROGRAM SOL NIMH-98-DB-0015 DUE 070798 POC Contracting Officer, David Eskanazi or Patricia Gibbons, (301) 443-2696 WEB: NIMH-98-DB-0015, http://www.nimh.nih.gov. E-MAIL: Click here to contact the contracting officer via email, de5d@nih.gov. The National Institute of Mental Health proposes to issue a solicitation (RFP) No. NIMH-98-DB-0015 entitled "NIMH Chemical Sythesis Program" as Full and Open Competition under SIC Code 2899. The NIMH plans to award a three year cost-reimbursement contract, and plans to make the award by September 30, 1998. This will a similar requirement to NIMH Contract N01MH30003 currently held by Research Biochemical International. The purpose of this contract is to 1) synthesize essential compounds such as psychoactive drugs, chemicals, probes, synthetic intermediates, radiolabeled compounds for autoradiography, that are unavailable from commercial sources to stimulate research on the molecular pharmacology and signal transduction mechanisms of central nervous system (CNS) receptors, molecular, biochemical, and behavioral actions of psychoactive drugs, and the development of potential therapeutic agents for the treatment of mental disorders. The resultant contract will provide chemical synthesis of selective ligands for CNS receptor subtypes, ion channel modulators, signal transduction agents, peptides, small molecules, and unlabeled precursors for use in neuroimaging as requested by NIMH-approved private and public investigators; and 2) to synthesize approximately 15-20 NIMH-approved compounds per year, store and maintain new and existing compounds in a central repository (the NIMH Chemical Inventory), maintain an electronic database of compounds with specificity information, and distribute compounds to NIMH-approved private and public investigators. Interested sources shall demonstrate the capability to carry out intermediate scale (10-1000 g) multi-step chemical syntheses (GMP and non-GMP), automated peptide synthesis, separation of enantiomers, preparation of families of structural analogs, purification of compounds, and documentation of chemical properties by analytic methods. The objectives of the contract will be to receive and test approximately 200 to 300 NIMH-approved and coded samples (synthetic compounds,gene products, and natural product extracts) per year in primary broad-based CNS receptor and enzyme screening assays, to test active samples in secondary functional assays, and to provide an electronic data file for each of the screened compounds. Request for Proposal (RFP) No. NIMH-98-DB-0015 will be available on or about June 2, 1998 and the receipt date of proposal on or about July 7, 1998. The RFP may be accessed through the NIMH Home Page by using the following instructions: access the home page at http://www.nimh.nih.gov, first select "Grants and Contracts", then select "NIMH Request for Proposals (RFP)", and lastly select "NIMH-98-DB-0015." Please note that the RFP for this requirement will include the Statement of Work, Deliverables and Reporting Requirements, the Technical Evaluation Criteria, and proposal preparation instructions. All information required for the submission of an offer will be contained in the electronic RFP package. Following proposal submission and initial review process, offerors comprising of the competitive range will be requested to provide additional documentation to the Contracting Officer. All responsible sources may submit a proposal that will be considered by the NIMH. This advertisement does not commit the Government to award a contract. (0138)

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