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A -- MEDICAL FREE ELECTRON LASER PROGRAM SOL BAA 98-016 DUE 050199 POC Dr. Michael T. Marron (202) 404-6128 BAA 98-016 A -- Medical Free Electron Laser Program Point of Contact: Dr. Michael T. Marron, (202) 404-6128 or marronm@onr.navy.mil. The Office of Naval Research invites submission of proposals aimed at exploiting unique features of free electron lasers for medical and related materials science research. Concept papers in advance of a formal submission are encouraged; they should be limited to 3 pages in length plus an estimated budget, relevant CV(s) and (p)reprints. Guidelines for preparation of formal proposals are provided below. The period of performance may be up to three years in length. Concept papers (3 copies) and formal proposals (a signed original and 6 copies) should be sent to MFEL Program, NRL Code 6900, 4555 Overlook Avenue, SW, Washington, DC 20375-5348. Proposals will be evaluated in accordance with the following criteria listed in descending order of importance: (1) overall scientific and technical merits of the proposal; (2) the offeror's capabilities, related experience, past performance, and facilities, or a unique combination of these that are integral factors for achieving the proposal objectives; (3) the qualifications and experience of the proposed principal investigator and key personnel; (4) relevance of proposed research to realizing medical applications of FELs; and (5) realism of the proposed cost and availability of funds. This is a Broad Agency Announcement as contemplated in FAR 6.102(d)(2) and will remain open for a period of one year following its publication. This is not a Request for Proposals nor is there a formal application form required. For awards made as contracts, the socio-economic merits will include the extent of commitment in providing meaningful subcontracting opportunities for small business, small disadvantaged business, woman-owned small business concerns, and historically black colleges and universities. Proposal guidelines and attachments are provided below. This is to notify potential proposers that each grant or cooperative agreement that is awarded under this announcement or solicitation to an institution of higher education must include the following clause: "As a condition for receipt of funds available to the Department of Defense (DoD) under this award, the recipient agrees that it is not an institution that has a policy of denying, and that it is not an institution that effectively prevents, the Secretary of Defense from obtaining for military recruiting purposes: (A) entry to campuses or access to students on campuses, or (B) access to directory information pertaining to students. If the recipient is determined, using procedures established by the Secretary of Defense to implement section 558 of Public Law 103-337 (1994), to be such an institution during the period of performance of this agreement, and therefore to be in breach of this clause, the Government will cease all payments of DoD funds under this agreement and all other DoD grants and cooperative agreements, and it may suspend or terminate such grants and agreements unilaterally for material failure to comply with the terms and conditions of award". If your institution has been identified under the procedures established by the Secretary of Defense to implement section 558, then: (1) no funds available to DoD may be provided to your institution through any grant, including any existing grant; (2) as a matter of policy, this restriction also applies to any cooperative agreement; and (3) your institution is not eligible to receive a grant or cooperative agreement in response to this solicitation. Medical Free Electron Laser Program The Office of Naval Research manages a research program for the Department of Defense aimed at exploiting unique features of free electron lasers (FELs) in medical and materials science research. We invite proposals for research leading to medical applications of FEL technology. The period of performance may be up to three years in length. PROPOSAL GUIDELINES An original plus six (6) copies of the proposal should be sent to: MFEL Program, NRL Code 6900, 4555 Overlook Avenue, SW, Washington, DC 20375-5348. Text for proposals should be at least 10 point type (12 point preferred) with at least 1.5 line spacing with 1" margins (top, sides, bottom). The following format should be used for preparing a proposal. A. Title Page (sample appended as Attachment 1) B. Table of Contents C. Statement of Objectives ( 1 page: What questions will you address?) D. Statement of the Approach ( 1 page: How will you address the questions?) E. Statement of Significance ( 1 page: What are the interesting questions? How is the research likely to lead to medical appliations of FELs?) F. Body of Proposal (30 pages) 1. Introduction and Background Information (5 pages: help the reviewers understand how the proposed research relates to the state-of-the-art in the field) (a) Previous work by others (b) Previous work by the investigator(s) (Preliminary data, manuscripts, and reprints may be included in an appendix, see Section M below) 2. Progress (5 pages; include only for renewalproposals) 3. Technical Approach (be sure to indicate who will perform each project when multiple projects are proposed) 4. References G. Management Plan (1 page: Who will be responsible for overall conduct of the program? How do different subprograms interface? This section is required only for multi-investigator proposals.) H. Facilities available (3 pages: especially, unique facilities or capabilities) I. Annual Budget (indicate institutional matching where appropriate) 1. Personnel salaries, wages and fringe benefits (indicate % effort) 2. Consultants (list by name and indicate time to be spent on the project) 3. Equipment -- purchase and maintenance, and justification for purchase 4. Materials and supplies 5. Travel (indicate purpose; identify and justify foreign travel) 6. Indirect Costs 7. Totals (provide annual breakdown and cumulative summary) J. CVs for investigators and consultants K. For all current and pending support (including proposals under review) of each investigator list: 1. Project title and one- or two-line summary 2. Source and amount of funding (include grant number for current grants) 3. Percentage effort devoted to each project 4. State how project is related to proposed effort L. Special information regarding certain types of experiments 1. Experiments involving animals Species justification, pain causation, or pain control. Statement of compliance with DOD-FAR 52.235-7003 (attachment 2) Copy of Institutional Animal Care and Use Committee approval 2. Experiments involving human subjects Statement of compliance with DHHS regulations, "Protection of Human Subjects" (45 Code of Federal Regulations 46, 1/26/81) Institutional Review Board Approval Form 3. Experiments involving recombinant DNA Statement of compliance with DHHS rDNA regulations Copy of Institutional Review Committee approval (if required) M. Appendices -- Preliminary data, manuscripts, reprints, and any other supporting materials (2 copies only; note that appendices are not seen by all reviewers) N. Certifications as found on the Office of Naval Research Homepage located at http://www.onr.navy.mil, under Business Opportunities, Broad Agency Announcements, How to Submit a Proposal. Review Criteria 1. Overall scientific and technical merits of the proposal. 2. The offerors' capabilities, related experience, and facilities, or a unique combination of these that are integral factors for achieving the proposal objectives. 3. The qualifications and experience of the proposed principal investigator and key personnel. 4. Relevance of proposed research to realizing medical applications of FELs. 5. Realism of the proposed costs. Attachment 1: Sample Title Page PROPOSAL SUBMITTED TO THE MEDICAL FREE ELECTRON LASER PROGRAM TITLE: Full title of proposal ABBREVIATED TITLE: ( 26 characters) INSTITUTION: Name and address of institution PRINCIPAL INVESTIGATOR(S): ____________________________________ _______________________________________ Principal Investigator Date Co-Principal Investigator Date Address: Address: Phone: Phone: E-mail address: INSTITUTIONAL ENDORSEMENTS _________________________________ _________________________________________ Administrative Head Date Institutional Financial Officer Date Address: Address: Phone: Phone: TOTAL COST: Dollar amount requested (include direct & indirect costs) DURATION: Duration of project and proposed starting date (duration 3 years) DATE SUBMITTED: This Proposal is Submitted Pursuant to the ONR Broad Agency Announcement, Dated (date of this BAA) ______________________________________________________________________ ________ Attachment 2: Department of Defense-Federal Acquisition Regulation 52.235-7003 a. Before undertaking performance of any contract involving the use of laboratory animals, the Contractor shall register with the Secretary of Agriculture of the United States in accordance with Section 6, P.L. 89-544, Laboratory Animal Welfare Act, 24 August 1966 as amended by P.L. 91-579, Animal Welfare Act of 1970, 24 December 1970. The contractor shall furnish evidence of such registration to the contracting officer. b. The Contractor shall acquire animals used in research and development programs from a dealer licensed by the Secretary of Agriculture or from exempted sources in accordance with the Public Laws enumerated in (a) above. c. In the care of any live animals used or intended for use in the performance of a contract, the Contractor shall adhere to the principles enunciated in the "Guide for Care and Use of Laboratory Animals" prepared by the United States Department of Agriculture's regulations and standards issued under the Public Laws enumerated in (a) above. In the case of conflict between standards, the higher standard shall be used. Contractor reports on portions of the contract in which animals were used shall contain a certificate stating that the animals are cared for in accordance with the principles enunciated in the "Guide for Care and Use of Laboratory Animals" prepared by the Institute of Laboratory Animal Resources, NAS-NRC, and/or in the regulations and standards are promulgated by the Agricultural Research Service, USDA, pursuant to the Laboratory Animal Welfare Act of 24 August 1996, as amended (P.L. 89-544 and P.L. 91-579). (0119)

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