National Cancer Institute, Acquisition Management Branch, TBS, 6120 Executive Blvd, EPS/Rm 603 Bethesda, MD 20892-7220

B -- RESYNTHESIS OF COMPOUNDS FOR PRECLINICAL DEVELOPMENT SOL N02-CM-07001-74 DUE 091599 POC Odessa S. Henderson, Contract Specialist, 301-435-3821 WEB: Research Contracts Branch Solicitation Website, http://rcb.nci.nih.gov/RFP.HTM. E-MAIL: henderso@rcb.nci.nih.gov, henderso@rcb.nci.nih.gov. The Developmental Therapeutics Program (DTP) of the National Cancer Institute (NCI), Division of Cancer Treatment and Diagnosis (DCTD) is soliciting organizations with expertise in organic synthesis to perform resynthesis of compounds needed for biological evaluations as potential anticancer agents. The Contractor shall synthesize target compounds as prioritized by NCI and deliver the synthesized compounds in amounts of 0.1 to 10.0 grams to the NCI repository. The synthesis assignments may on rare occasions include parallel synthesis or deconvolutions of small combinatorial libraries, and syntheses of a few selected analogs of known compounds. Synthesis and delivery of 15 to 25 target compounds average per year are anticipated, with requirements of 45 -- 75 for the three year base period, 50 -- 100 if Option 1 (Year 04) is exercised and a five year total of 75 -- 125 if Option 2 (Year 05) is exercised. The Contractor shall prepare Material Safety Data Sheets for all single compounds and libraries which are delivered, and check the purities of compounds when requested. It is anticipated that one award will be made as a result of the solicitation with a base period of three years plus two one-year options, for a total of five years if all options are exercised. The contract type will be an incrementally funded, completion-type cost reimbursement contract. The following mandatory qualification criteria will apply: (1) the Contractor cannot be a commercial pharmaceutical, chemical or biotechnology firm since agents of a commercially confidential nature (discreet) may be evaluated; (2) as many of the compounds assigned for resynthesis may be of a hazardous nature, the Contractor shall have the necessary licenses required by Local, State and Federal governments to handle, synthesize, store and ship such compounds and dispose of toxic waste. SIC for this acquisition is 8731. The solicitation is scheduled for electronic release o/a July 30, 1999. The proposed acquisition is a recompetition of contract N01-CM-47015 awarded to Starks Associates, Inc. This acquisition has been designated as a 100% small business set-aside. The RFP may be accessed through the Research Contracts and Acquisition Branch homepage by using the following internet address -- http://amb.nci.nih.gov It is the offeror's responsibility to monitor the above internet site for the release of this solicitation and any amendments. POTENTIAL OFFERORS WILL BE RESPONSIBLE FOR DOWNLOADING THEIR OWN COPY OF THE SOLICITATION AND AMENDMENTS. No collect calls will be accepted. See Numbered Note 1. Posted 07/01/99 (W-SN349464). (0182)

Loren Data Corp. http://www.ld.com (SYN# 0017 19990706\B-0006.SOL)